Disregard Everything I Say

Duration,
Total : 6 - 10 hrs
Onset : 15 - 120 mins
Plateau : 2 - 4 hrs
Coming Down : 1 - 4 hrs

Dosage,
Threshold : 50 - 250 ug (micrograms)
Light : 200 - 600 ug
Common : 500 - 800 ug
Strong : 700 - 1500 ug

25I-NBOMe can be fatal at heavy doses.^[1] It is strongly discouraged to take large amounts of this substance or to snort it.

25I-NBOMe or 2C-I-NBOMe is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-I.

It has nearly no history of human use prior to 2010 when it first became popular due its ease of purchase from online research chemical vendors.

25I-NBOMe was discovered in 2003 by Ralf Heim at the Free University of Berlin. It differs from 2C-I structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group as shown in the image above. This change in structure results in a sixteen fold increase in potency when compared to 2C-I, allowing even the most extreme of dosages to fit in liquid form onto tabs and blotter paper (which people often mistake for LSD).

There are, however, methods of differentiating between LSD and adulterants like 25I-NBOMe with and without test kits.

For example, one of the key differences between 25I-NBOMe and LSD is that this substance is only active when taken through a sublingual or insufflated route. This means that in order to get the full effects, 25I-NBOMe blotter paper must be lightly chewed on within the mouth for 10 - 20 minutes and never immediately swallowed.

Insufflation, however, is not recommended due to the amount of people who have suffered through dangerous and often fatal overdoses due to this route of administration.

25I-NBOMe is pharmacologically unique when compared to other psychedelics through the way in which it is one of the only full agonists for the human 5ht2a receptor in existence. In comparison, classical psychedelics such as LSD, DMT and psilocin can only be considered partial agonists.

This difference in receptor affinity results in an unusual and qualitatively different trip which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical effects:

The physical effects of 25I-NBOMe can be broken down into six components all of which progressively intensify proportional to dosage. These are described below and generally include:

• Sublingual numbing - assuming the substance has been taken sublingually, the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very obvious feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed. This is the key difference when it comes to determining whether your blotter paper contains LSD or one of the NBOMe series.
• Spontaneous tactile sensations - the body high itself can be described as a generally mild, all-encompassing, soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of euphoria that become longer and more drawn out proportional to the dosage consumed.
• Decreased bodily weight - in terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness.
• Stimulation - in terms of its effects on the physical energy levels of the tripper 25I-NBOMe is usually considered to be very energetic and stimulating. For most people, this substance induces a unique type of physical stimulation which can be described as feeling extremely energetic but in a way which does not force the tripper to move unless they genuinely choose to do so. For others however, the stimulation can be quite uncontrollable, occasionally resulting in bodily shakes and a grinding of the teeth comparable to that of MDMA and traditional stimulants such as amphetamine.
• Vasoconstriction - this is defined as the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels and is triggered through the way in which 25I-NBOMe’s target receptor (5-HT2A) modulates both vasoconstriction and vasodilation among its many other functions. It can be described as feelings of tightness within one’s arms and legs.
• Nausea - as the tripper begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, but passes once this has either happened or the trip begins to fully set in. In comparison to other psychedelics such as psilocin, LSD, 2C-E and 2C-I, this could actually be very considered very mild in its intensity.

Cognitive effects:

The head space of 25I-NBOMe is described by many as remarkably light and underwhelming in comparison to the classical psychedelics. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout low to moderate dosages. At high dosages however, mild to overwhelming cognitive alterations become present.

The most prominent of these cognitive effects generally include:

• Introspection - this component is consistently manifested only in the context of a non-social setting in which the user is alone.
• Acceleration of thought
• Ego suppression, loss and death
• Time distortion
• Feelings of fascination, importance and awe
• Conceptual thinking
• Connectivity of thought
• Enhancement of current mind state
• Removal of cultural filter
• Increased empathy, love and sociability - the entactogenic effects range from mild to powerful, but are inconsistently manifested. Entactogenic effects for people who try this substance usually become prominent in the presence of others. These feelings of increased sociability, love and empathy do not seem to be quite as strong or profound as those found within other entactogens (such as MDMA, 2C-B and AMT)

Visual effects:

Enhancements

25I-NBOMe presents a full and complete array of possible visual enhancements which generally include:

• Increased visual acuity
• Enhancement of colours
• Enhanced pattern recognition

Distortions

The visual distortions and alterations which are experienced are detailed below:

• Visual drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in their appearance and unrealistic/cartoon like in style.
• Tracers
• After images
• Texture repetition - In comparison to other psychedelics such as LSD or psilocin, this particular visual alteration is significantly more basic and less intricate in style but still distinctively present.

Geometry

The visual geometry that is present throughout this trip is often described as similar in appearance to that of LSD. They can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colourful in scheme, glossy in colour, sharp around the edges and mostly rounded across their corners. In comparison to other more commonly used psychedelics, they can be described as significantly more intricate than the visual geometry found within 2C-I and most of the 2C-x family and are completely on par with LSD, Psilocin and DMT at appropriately high dosages.

In terms of their behaviour, 25I-NBOMe’s geometry leads onto Level 7A visual geometry with Level 7B remaining so far unconfirmed within this substance. They also seem to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelops the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it.

Hallucinatory states

25I-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. However, level 4 hallucinatory breakthroughs are reported but very uncommon and inconsistent in comparison to other more commonly used psychedelics such as psilocin, 2C-E and DMT.

These effects include:

• External hallucinations
• Internal hallucinations - this particular effect commonly contains hallucinations within scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.

Auditory effects:

The auditory effects of 25I-NBOMe are common in their occurrence and exhibit a full range of effects which commonly include:

• Enhancements
• Distortions
• Hallucinations

Health effects, addiction potential and tolerance:

25I-NBOMe is a very new substance and little is known about its pharmacological or behavioural risks. The LD50 is not known. Some deaths have been attributed to 25I-NBOMe overdoses caused by improper handling and uneducated use of this substance. Its recent widespread use suggests that death is primarily caused from overdoses and not from ordinary doses, particularly from insufflation.

The fact that 25I-NBOMe is active in the microgram range is likely a contributing factor since this makes measuring doses significantly more difficult. 

It’s worth noting that although many 5-HT2A agonists have documented safety, none of these have been full agonists so their safety data cannot be applied to 25I-NBOMe.

In terms of its addictive potential, 25I-NBOMe has not been studied formally but due to its immediate tolerance build up which lasts up to 2 - 3 weeks after the experience, it is essentially impossible to use this substance compulsively.

Legal issues:

• 25I-NBOMe is unscheduled under United States federal law. However, it could possibly be considered an analog of 2C-I (a Schedule I controlled substance) under the Federal Analogue Act. In this case, sale or possession of 25I-NBOMe with the intent of human consumption would be illegal.
• Virginia, Louisiana, and Florida have specifically scheduled 25I-NBOMe as a Schedule I controlled substance.
• All NBOMe substituted phenethylamines are controlled in Russia.

In other countries, however, 25I-NBOMe is completely unscheduled and freely available to anybody with an internet connection. If you wish to obtain this substance despite the risks involved you can literally type “buy 25I-NBOMe” into google and find several legitimate vendors on the very first page.

Please keep in mind however that 25I-NBOMe is NOT being sold by anybody specifically for the purposes human consumption as this would be genuinely illegal within most if not all countries.

Reader submitted trip reports:

• Unknown dosage / 1 tabs - Prolonged unity and messiah syndrome at school by H0bcnd2
  
• Unknown dosage / 3 tabs - Ego death and a total break through in the snow by H0bcnd2
• 1000ug / 1 tab - No sense of enlightenment but absolutely breath taking visuals by Anonymous
• Unknown dosage - Ego death and becoming one with a singular entity by Anonymous

Conclusion:

In conclusion, 25I-NBOMe is an extremely interesting psychedelic but does not quite compare in terms of visual and cognitive depth if you have access to classical psychedelics such as genuine LSD, DMT and psilocin.

I will not be seeking this substance out again but experimenting with it has certainly been an interesting and enjoyable experience.
Please go ahead and let me know if you agree or disagree with any particular points contained within this article by using the comment system below.

Click here for a more comprehensive breakdown.

This article is dedicated to providing a detailed description for one of four previously undocumented cognitive components of the psychedelic experience which I am currently in the process of writing up. I have experienced this component throughout every single one of my countless trips over the past 3 years. Despite this however, it has taken me 2 and half years to develop a vocabulary which was capable of even noticing its presence, several months to formulate a description which could be considered comprehensive in my own eyes and even longer to pin down a suitable title for that which has never before been named.
This specific component is not a high level effect and can generally be felt along side and above level 1 – 3 psychedelic geometry. It is extremely common and could be described as universal, occurring at varying levels under the influence of almost every psychedelic compound known to man.
So far this list confirms through myself and others to include but certainly not remain limited to,
Psilocin, Psilocybin, Psilacetin, Mescaline, DMT, Ayahuasca, LSD, LSA, AMT, Harmine, 2C-B, 2C-E, 2C-I, 2C-P, and 5-MeO-DMT.

The emancipation of our internal narrative from the limitations of exclusively linguistic content can be described as a forced change in perspective which frees the ego’s conscious thought stream from remaining strictly limited to words and labels. This allows it to think not just in descriptions, but directly in the internally stored concepts that lay behind our linguistic and descriptive knowledge base.
In terms of how this feels experientially, it can be described as the sensation of the concepts behind the words of our internal narrative becoming somehow cognitively felt at every point across themselves in a very high level of detail. Along side this they are also perceived through a simultaneous partially to fully animated visual manifestation that differs from that of an ordinary hallucination through the fact that it exclusively occurs within the minds eye, always remaining completely separate from the trippers direct line of sight.
The experience of directly experiencing the internally stored concepts which lay just behind human description results in the perceived ability of being able to clearly feel in a profound and emotionally intuitive format, the precise consequences, limitations and position within this universe of any singular concept. These feelings are consistently interpreted as a “higher level of understanding” which seems to stem from the way in which this perspective reveals human language to be intrinsically self limited. This intrinsic self limitation is shown by integrating previously held knowledge into a persons felt perspective, transcending our intellectually understood knowledge and showing that words can only act as mere shortcuts to the concepts which they exist to describe.
At lower levels, these integrations of previously held knowledge into the trippers felt perspective can be described as thought stream specific. This means that the concepts which are being felt and seen are exclusively relevant to the words which you are currently thinking. These will feel identical in stylistic behavior whether the concept is arrived at by a simple wandering of thoughts or triggered through the experience of a concept or object perceived within the external environment. 
Perhaps the most common example of this which those within the psychedelic community could relate to would be the experience of looking at a plant of any sort and internally feeling as well as visually perceiving, everything that you happen to know about photosynthesis and the evolution of plants no matter how vague or abstract this knowledge might be.
At higher levels, these integrations of previously held knowledge into the trippers felt perspective stop being specific to the words contained within your current thought stream and start becoming all encompassing towards every last internally stored piece of knowledge the tripper has ever known.
This leads onto feelings which are consistently interpreted as a new found level of “total and complete understanding” as the consequences, limitations and position within this universe of every single concept which the tripper previously only knew in terms of its description, becomes felt through a very real and undeniable perspective.
Perhaps the most common examples of these which those within the psychedelic community will relate to, that I have experienced myself and observed through others, would be the experience of a total and profound understanding regarding but not limited to, the themes and archetypes listed below.

• General scientific principles.
• Taking care of your personal health.
• Your position within nature and higher systems of order.
• The consequences of your actions and your responsibility towards them.
• Human civilization as the literal cutting edge of physical complexity.
• Living in balance with nature to the best of your abilities.
• The inevitability of death.
• The sheer unlikeliness of personal existence.

It’s through the direct experience of the concepts behind our knowledge that new life changing perspectives are suddenly felt in an obvious way. These new found viewpoints are rarely considered by the tripper to be the creation of a single new idea or creative insight. Instead they are nothing more than the integration of previously held knowledge which was already understood intellectually into a new fou them in an undeniable, clearly understandable and emotionally felt format which lies within a level of detail far beyond normal human language and description.
At lower levels, these integrations of knowledge are felt to be temporary and consistently subside along with the effects of the substance which has been consumed.
At higher levels however, specific or all encompassing pieces of knowledge can become permanently integrated into a trippers felt perspective for weeks, months, years and even a lifetime after the experience itself. If the knowledge integration has been specific it will likely consist of things which have been only recently learnt or discovered in the preceding days or perhaps weeks before the trip.
This component allows psychedelic users to gain access to a profound and very literal expansion of their consciousness, resulting in extremely therapeutic changes in their perception of the world. 

It’s worth noting however that many people including myself have reported that they can experience low level versions of this component when simply high on marijuana.
Personal experience has led me to confirm that this state can even be triggered throughout every day life in temporary, thought stream specific forms through mindful meditation sessions. I have yet to write anything regarding my knowledge behind meditation but intend to at some point in the future and will tie the relevant parts of it directly into this component.

If you have had any experience with this component whatsoever please do report this in the comment section below and the drug or mind state which it occurred on. This provides myself and everybody else with extremely valuable data and would be greatly appreciated.