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January 26th, 2015 at 10:39AM

2C-C, broken down and described

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Dosage (oral)
Threshold : 5 - 10 mg
Light : 10 – 30 mg
Common : 30 – 50 mg
Strong : 50 – 70 mg
Heavy : 70+ mg

Duration (oral)
Total duration : 4 - 6 hours
Onset  : 1 - 3 hours
Peak : 2 - 3 hours
Come down : 1 - 2 hours
After effects : > 2 hours

2C-C (2,5-Dimethoxy-4-chlorophenethylamine) is a psychedelic phenethylamine of the 2C-x family.[1] It was first synthesized by Alexander Shulgin and described in his 1991 book PiHKAL: A Chemical Love Story.

In modern times, it is used as a recreational drug and an entheogen, rarely sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors. Therefore, it is relatively uncommon and has only a short history of human use.

Many users report that 2C-C is gentler and more sedating than other closely related psychedelic phenethylamines.

In terms of its chemistry, 2C-C is a substituted phenethylamine with methoxy groups attached to carbons R2 and R5 as well as a chlorine attached to carbon R4.

In terms of its pharmacology, 2C-C’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects:

The physical effects of 2C-C can be broken down into 9 components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Spontaneous tactile sensations - The “body high” of 2C-C can be described as a pleasurable, warm, soft, all-encompassing and mild tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
  • Stimulation and Sedation - In terms of its effects on the physical energy levels of the tripper, the 2C-C experience begins with mild stimulation, but usually becomes very sedating as the experience progresses and lacks the distinctive energetic feeling associated with most phenethylamines. This feeling was accurately described in Alexander Shulgin’s PiHKAL as “an intense form of relaxation.”
  • Nausea - Although nausea remains present, in comparison to other phenethylamines such as 2C-E, 2C-I or 2C-B, this remains extremely mild and dissipates quickly even with higher dosages. It is perhaps one of the most physically underwhelming psychedelics out there for this reason alone.
  • Bodily control enhancement and Motor control loss - Whilst at lower doses one may find that their bodily control is enhanced, at higher dosages it seems to become suppressed.
  • Tactile enhancement
  • Temperature regulation loss
  • Salivation
  • Increased heart rate

Cognitive effects:

The head space of 2C-C is described by many as one which is both insightful and relatively normal in its thought processes even at moderate to high dosages.

The total sum of these cognitive components regardless of the setting generally includes:

Visual effects:

Enhancements

2C-C presents a full and complete array of possible visual enhancements which generally includes:

Distortions

2C-C presents a full and complete array of possible visual distortions which generally includes:

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT or Ayahuasca than that of LSD, 2C-B or 2C-I. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, slow and smooth in motion, colourful in scheme, glossy in colour, equally blurred and sharp in their edges and equally rounded and angular in their corners. They give off a contradictory natural and synthetic feel to them that at higher dosages. While the geometry for 2C-C has yet to be formally confirmed, it seems more likely to result in states of Level 8B visual geometry over Level 8A.

Hallucinatory states

2C-C produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the phenethylamine family. These effects include:

  • Transformations
  • Internal hallucinations - In comparison to other psychedelics such as LSD, 2C-C is extremely high in hallucinations embedded within visual geometry. This particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.
  • External hallucinations - 2C-C is capable of external hallucinations embedded within visual geometry. This particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They can be described as external in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.
  • Machinescapes

Auditory effects:

The auditory effects of 2C-C are common in their occurrence and exhibit a full range of effects which commonly include:

Physical health effects, potential addiction and tolerance:

The toxicity and long term health effects of recreational 2C-C use do not seem to have been studied in any scientific context and the median lethal dose (LD50) is unknown. This is because 2C-C is a research chemical with very little history of human usage. Anecdotal evidence from those who have used 2C-C would suggest that there are little to no immediate or short-term negative health effects attributed to simply trying the drug at low to moderate doses or using it very sparingly. The validity of these statements, however, cannot be confirmed.

The addictive potential of 2C-C has not yet been formally studied, but anecdotal evidence would suggest that 2C-C is not physically addictive. Many users describe a self-regulating quality and commonly report a tolerance build up when using the drug consecutively many days in a row. A build up in tolerance may lead to weakened effects and a diminished experience, however, this effect is nearly non-existent when consumption periods are spaced 5-7 days apart.

Legal issues:

  • United States: 2C-C is listed in schedule I of section 202(c) of the Controlled Substances Act in the United States. This was signed into law as of July 2012 under the Food and Drug Administration Safety and Innovation Act.
  • United Kingdom: 2C-C is a class A controlled substance as it is covered by the phenethylamine derivatives clause of the Misuse of Drugs Act of 1971.
  • Sweden: 2C-C is classified as a “health hazard” as of March 1, 2005 in their regulation SFS 2005:26, making it illegal to sell or possess.
  • Japan: 2C-C is controlled by the Pharmaceutical Affairs Law in Japan, making it illegal to possess or sell.
  • Australia: Australia has a blanket ban over all substituted phenethylamines including the entire 2C-X family.

Conclusion:

Despite its lack of relative potency, 2C-C definitely holds up as an excellent psychedelic and is particularly useful for those who are inexperienced. Although I have yet to determine the proper dosage for this method, I would highly recommend smoking or vaporizing this compound using a standard water bong (like one used to smoke cannabis) as it delivers an intense experience which is somewhat on par with a phenethylamine-esque DMT breakthrough experience.

This substance breakdown was written through collaboration between PsychonautWiki contributors PJosepherum, Josikins and Oscarette. The full article, including references, is available here.

21 notes
January 8th, 2015 at 5:00PM

Diphenidine, broken down and described

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Dosage (oral)
Threshold : 50 mg
Light : 70 – 85 mg
Common : 85 – 110 mg
Strong : 110 – 150 mg
Heavy : >150 mg

Duration (oral)
Total duration : 2 - 5 hours
Onset  : 15 - 30 minutes
After effects : 4 - 24 hours

Diphenidine (1-(1,2-diphenylethyl)piperidine) is a dissociative NMDA receptor antagonist and anesthetic drug that has been sold online as a research chemical.

The synthesis of diphenidine was first reported in 1924 and employed a nitrile displacement reaction analogous to the one that would later be used to discover phencyclidine in 1956. Shortly after the 2013 UK ban on arylcyclohexylamines, diphenidine and the related compound methoxphenidine became available on the grey market. Anecdotal reports describe high doses of diphenidine producing “bizarre somatosensory phenomena and transient anterograde amnesia.”

In 2014, there have been two published reports of diphenidine being sold in combination with synthetic cannabinoids in Japanese herbal incense blends. A herbal incense sold in the Shizuoka Prefecture under the name “Aladdin (sic) Spacial Edition” was found to contain diphenidine and 5-fluoro-AB-PINACA at concentrations of 289 mg/g and 55.5 mg/g, respectively. Another product called ‘‘Herbal Incense. The Super Lemon’’ containing AB-CHMINACA, 5F-AMB, and diphenidine was implicated in a fatal overdose.

Based on collaborative anecdotal evidence, diphenidine seems to have a much more rapid onset and lower half life when vaporized or smoked. When consumed this way, it is a suspected to be carcinogenic when excess heat is used. Some user reports have concluded that vaporization requires as low as 20% of what would be a common oral dose for that person.

In terms of its chemistry, diphenidine is a diarylethylamine related to methoxphenidine. It is named for its two phenyl and piperidine groups. Diphenidine’s crystalline structure is very similar to MK-801 (Dizocilpine) and shares many of the same effects. These two compounds are homeomorphs. Diphenidine is synthesized in a reaction analogous to the synthesis of PCP. The (R)-enantiomer of diphenidine has a remarkable high affinity as a NMDA receptor channel blocker.

In terms of its pharmacology, diphenenidine acts as an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. NMDA receptor antagonists close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually the famous “hole”.

Although vendors of diphenidine have stated the compound acts as a dopamine-reuptake inhibitor and a serotonin reuptake inhibitor with µ-opioid affinity and typical dissociative effects, to date diphenidine has not been screened for affinity at the dopamine transporter. If this is indeed the case, however, it provides an explanation for its euphoric and often stimulating effects.

Diphenidine and related diarylethylamines have been studied in vitro as treatments for neurotoxic injury. Diphenidine may be a stronger NMDA receptor antagonist for neurogenis and neurological repair than other more common NMDA receptor antagonistic dissociatives such as ketamine, dextromethorphan, PCP analogs, Iboga and methoxetamine.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects:

The subjective physical effects of diphenidine can be broken down into nine components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Tactile disconnection
  • Spontaneous tactile sensations - The diphenidine body high is a sharp, pleasurable tingling sensation which is location specific to the hands, feet and head.
  • Tactile suppression - This partially to entirely suppresses one’s own sense of touch, creating feelings of numbness within the extremities. It is responsible for the anaesthetic properties of this substance.
  • Physical autonomy
  • Motor control loss - A loss of gross and fine motor control alongside of balance and coordination is prevalent within diphenidine and becomes especially strong at higher dosages. This means that one should be sitting down before the onset (unless one is experienced) in case of falling over and injuring oneself.
  • Euphoria - This results in feelings of physical euphoria which range between mild pleasure to powerful all-encompassing bliss.
  • Decreased bodily weight - This creates the sensation that the body is floating and has become entirely weightless. This effect is strangely stimulating and encourages physical activities at low to moderate dosages by making the body feel light and effortless to move.
  • Dizziness - Although uncommon, some people report dizziness under the influence of diphenidine.
  • Nausea - It’s worth noting that high dose diphenidine trips can sometimes result in nausea and vomiting at the peak of the trip. For most people, this is surprisingly not as unpleasant as they would initially expect due to the accompanying detachment from the physical senses.

Cognitive effects:

The general head space of diphenidine is often described as particularly euphoric and clear headed in comparison to that of DXM and Ketamine. The specific cognitive effects can be broken down into 8 separate subcomponents which are listed and described below:

Visual effects:

Suppression:

This substance does not enhance visual stimuli; instead it tends to degrade and decrease visual aptitude in a variety of ways which generally includes:

Distortions:

Diphenidine exhibits a full array of dissociative distortions and alterations in visual perception which generally includes:

Geometry:

The visual geometry found within diphenidine can be described as very dark and bland when compared to that of Ketamine or DXM and often consists of many tiny interlocking and woven lines. It does not extend beyond level 4 and can be comprehensively described through its variations as simplistic in complexity, algorithmic in style, synthetic in feel, unstructured in organization, dimly lit in lighting, multicoloured in scheme, glossy in shading, soft in edges, small in size, slow in speed, smooth in motion, equal in rounded and angular corners, immersive in depth and consistent in intensity.

Hallucinatory states:

At high dosages, diphenidine can produce a full range of high level hallucinatory states in a fashion that that is less consistent and reproducible than that of many other commonly used psychedelics. These effects include:

Auditory effects:

The auditory effects are common in their occurrence and exhibit a range of effects which commonly includes:

Physical health effects, potential addiction and tolerance:

The toxicity and long term health effects of recreational diphenidine use does not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because diphenidine is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried diphenidine within the psychonaut community suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).

There is a very strong tolerance build up with diphenidine which results in the need to consume increasingly large doses in order to achieve the same level of effects. This should reset to baseline after 1 - 2 weeks. There may well be some addictive potential but this is still unknown.

Tolerance may be mitigated via preparing the citrate salt by mixing the chemical with citric acid or lemon juice, which will aid in absorption and increase effects.

Legal issues:

Diphenidine is currently a legal grey area drug worldwide and is freely available through the use of online research chemical vendors. However, this does not guarantee anyone to be immune from legal prosecution should they be found in possession of this substance as the legality is likely to vary from country to country.

Conclusion:

In conclusion, diphenidine feels almost identical to MXE with only subtle differences. It is a powerful hallucinogen and just as capable of inducing deep states of detachment which rival that of the other more commonly used dissociatives.

This substance breakdown was written through collaboration between PsychonautWiki contributors Kaylee, PJosepherum, Josikins and Oscarette. The full article, including references, is available here.

16 notes
December 31st, 2014 at 11:49AM

25N-NBOMe, broken down and described

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Dosage (oral)
Threshold : 150 µg
Light : 150 – 450 µg
Common : 450 – 1000 µg
Strong : 1000 – 2000 µg
Heavy : 2000 µg

Duration (oral)
Total duration : 4 - 6 hours
Onset  : 15 - 60 minutes
Peak : 2 - 3 hours
Come down : 2 - 3 hours
After effects : 5 - 10 hours

25N-NBOMe (2C-N-NBOMe) is a derivative of the substituted phenethylamine psychedelic 2C-N which was discovered in 2004 by Ralf Heim at the Free University of Berlin and subsequently investigated by a team at Purdue University led by David Nichols.

25N-NBOMe has a notably shorter duration than the rest of the 25x-NBOMe series, with a total duration of 6 hours and a peak duration of 2 hours. It is moderately active at a 1mg dosage, and a dose of 2mg provides a strong/heavy trip. This substance is considerably less potent when compared to the more popular NBOMes such as 25B-NBOMe, 25I-NBOMe, and 25C-NBOMe, all of which lead to strong trips at 1mg+ doses.

In terms of its chemistry, 25N-NBOMe is a substituted phenethylamine with methoxy groups attached to carbons R2 and R5 as well as a nitrophenyl group attached to carbon R4. It differs from 2C-N structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group, which in turn increases potency about a hundred fold.

In terms of its pharmacology, 25N-NBOMe has efficacy at the 5-HT2A receptor where it is assumed to act as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive. At the time of this article’s writing, there is insufficient scientific research to determine this compound’s true nature as the pharmacological properties of 25N-NBOMe have not been described in the literature but only in anecdotal reports. 25N-NBOMe has been sold as a street drug and has only been described in the literature in terms of identification by forensic analysis.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical Effects:

The physical effects of 25N-NBOMe can be broken down into seven components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Wakefulness - 25N-NBOMe may induce wakefulness as a component of its stimulation.
  • Stimulation - In terms of its effects on the energy levels of the tripper, 25N-NBOMe is quite stimulating, and leftover stimulation can linger up to 10 hours even after the trip subsides.
  • Vasoconstriction - This substance is known to induce mild vasoconstriction as a component of its stimulation.
  • Tactile enhancement - 25N-NBOMe increases tactile sensory input and feedback which intensifies tactile comfort and discomfort as well as pleasure and pain.
  • Bodily control enhancement - The drug increases muscle and bodily control. When combined with stimulation, this component manifests as a strong drive to partake in physical activities.
  • Runny nose - 25N-NBOMe may cause a runny nose and increased mucus production in some users.
  • Nausea - Users (especially those prone to it) may experience nausea during the onset. The nausea will subside over the peak.

Cognitive Effects:

The cognitive effects of 25N-NBOMe can be described as quite reminiscent to that of 25C-NBOMe's effects. They can be broken down into nine components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Time distortion - Time may strongly dilate or compress on 25N-NBOMe, especially during the peak. This depends on the situation and the user.
  • Introspection - The substance can cause introspective thinking, allowing for the detailed inspection of both events and concepts.
  • Conceptual thinking - 25N-NBOMe may cause conceptual thinking (which synergizes very well with introspection), allowing for the detailed inspection of concepts.
  • Thought connectivity - This drug may cause thought connectivity which makes for a more fluid and morphing train of thought and therefore may sometimes trigger thought loops.
  • Feelings of self-design - 25N-NBOMe may cause feelings of self-design as a result of detailed introspection and loss of personal bias.
  • Novelty enhancement - 25N-NBOMe regularly causes fascination, importance and awe due to its varying and synergistic cognitive effects.
  • Cognitive euphoria - The cognitive euphoria of 25N-NBOMe resembles that of 25C-NBOMe in that it manifests in waves that alternate between peaking and receeding.
  • Laughter - There is an increased proneness to laughter and joy at moderate and heavier doses.
  • Disinhibition - The combination of stimulation and joy from the 25N-NBOMe may lead to disinhibition for some users.

Visual effects:

Enhancements

Distortions

  • Symmetrical texture repetition - At higher dosages, this proceeds into 3-Dimensional textures.
  • 3-Dimensional textures - At moderate and heavier doses, the textures will become 3-dimensional or holographic and appear to float/drift through space/air.
  • Drifting (Melting, Flowing, Breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in their appearance and unrealistic/cartoon-like in style.

Geometry

The visual geometry that is present throughout this trip is often described as similar in appearance to that of LSD. They can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colourful in scheme, glossy in colour, sharp around the edges and mostly rounded across their corners.

In terms of their behaviour, 25N-NBOMe’s geometry leads onto Level 8A visual geometry with Level 8B remaining so far unconfirmed within this substance. They also seem to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelops the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it.

Hallucinatory states

Auditory effects:

The auditory effects of 25B-NBOMe are common in their occurrence and exhibit a full range of effects which commonly includes:

Physical Health Effects, Potential Addiction and Tolerance:

The toxicity and long term health effects of recreational 25N-NBOMe use does not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 25N-NBOMe is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychedelic community who have tried 25N-NBOMe suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).

Although unknown and unproven, lethal dose with NBOMes are assumed to be 10mg+ oral and 5mg+ intranasal. Please proceed with caution. However, users should be very careful and consider that ingesting 2mg+ of NBOMe series chemicals have proven fatal in some cases, although there are no reported fatalities caused by 25N-NBOMe at the time of the writing of this article.

In terms of its addictive potential, 25N-NBOMe has not been studied formally, but due to its immediate tolerance build up, which lasts up to 2 - 3 weeks after the experience, it is difficult to use this substance compulsively.

Legal issues:

  • Brazil: The possession, production and sale is illegal.

  • USA: 25N-NBOMe is unscheduled in the United States. It may be considered an analog of 2C-N (which is a Schedule I drug under the Controlled Substances Act). As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analog Act.

  • UK: The 25x-NBOMe series is under a temporary class drug order, lasting one year from 10th June 2013.

Conclusion:

This substance breakdown was written through collaboration between PsychonautWiki contributors Argent, Josikins and Oscarette. The full article, including references, is available here. Have a happy New Year! :)

13 notes
November 4th, 2014 at 1:40AM

2C-T-2, broken down and described

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Dosage (oral)
Threshold : 3 - 5 mg
Light : 10 - 15 mg
Common : 15 - 20 mg
Strong : 20 - 30 mg
Heavy : 25mg - 40mg

Duration (oral)
Total duration : 5 - 10 hours
Onset  : 60 - 90 minutes
Peak : 3 - 7 hours
Come down : 1 - 2 hours
After effects : 2 - 4 hours

Dosage (insufflated)
Threshold : 1 - 3 mg
Light : 2 - 5 mg
Common : 5 - 15 mg
Strong : 5 - 20 mg
Heavy : 7 - 25mg+

Duration (insufflated)
Total duration : 3 - 7 hours
Onset : 5 - 15 minutes
Peak : 2 - 4 hours
Come down : 1 - 2 hours
After effects : 1 - 2+ hours

2C-T-2 (2,5-dimethoxy-4-ethylthiophenethylamine) is a psychedelic phenethylamine of the 2C-x family. It was first synthesized by Alexander Shulgin in his book PiHKAL: A Chemical Love Story. This particular substance is part of the so-called “magical half-dozen” which refers to Shulgin’s self-rated most important phenethylamine compounds, all of which except mescaline he developed and synthesized himself. They are found within the first book of PIHKAL, and are as follows: Mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7.

2C-T-2 is a highly dose sensitive psychedelic known for its strong visuals and very intense body load. Many reports also indicate that the physical effects are too severe for those who are not already experienced with psychedelics or suffer from pre-existing physical conditions, as it is known to cause powerful nausea and general bodily discomfort.

In terms of its chemistry, 2C-T-2 is a synthetic, substituted phenethylamine with methoxy groups attached to carbons R2 and R5 as well as a sulfide chain attached to carbon R4. 2C-T-2 is nearly identical in structure to 2C-T-7. The two molecules differ in the length of their sulfide chain; 2C-T-7 contains a propyl thioether group while 2C-T-2 contains a ethyl thioether group.

In terms of its pharmacology, the mechanism of action that produces 2C-T-2’s hallucinogenic and entheogenic effects has not been established in scientific literature, however its primary psychedelic effects are more than likely a result from its efficacy at the 5-HT2A receptor as a partial agonist. This mechanism of action is shared by many other psychedelic phenethylamines and tryptamines.

Athough no established scientific experiments have been preformed to establish MAO-A inbihition of 2C-T-2, phenethylamine derivatives substituted with an alkylthio group at the 4 position (such as 2C-T-7, 4-MTA, and the 2,5-desmethoxy derivative of 2C-T-7) are known to act as selective monoamine oxidase A inhibitors. Therefore, this substance may likewise have MAOI effects.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical Effects:

The physical effects of 2C-T-2 can be broken down into eight components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Spontaneous tactile sensations - The body high of 2C-T-2 can be described as very intense and uncomfortable in comparison to 2C-E or 2C-B. In high doses, it’s capable of causing painful cramping. It is similar yet distinct from the body high experienced on 2C-T-7, but is considered much more unpleasant. The sensation itself can be described as intense and may manifest itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
  • Stimulation - In terms of its effects on the physical energy levels of the tripper, 2C-T-2 is usually considered to be very energetic and stimulating in a fashion that is quite comparable to that of other phenethylamines such as 2C-B, 2C-E and 2C-P.
  • Bodily control enhancement - Although this component is capable of manifesting itself in a distinct and noticeable fashion for most users, it does not generally seem to be as apparent or intense as the same component found within LSD and 2C-B.
  • Tactile enhancement
  • Nausea - Extreme nausea is commonly reported when consumed in moderate to high dosages and either passes once the tripper has vomited or gradually fades by itself as the peak sets in. It can be described as very painful and violent in comparison to 2C-T-7 or 2C-E.
  • Stomach cramps
  • Vasoconstriction
  • Temperature regulation loss

Cognitive Effects:

The head space of 2C-T-2 is described by many as one which is both insightful and relatively normal in its thought processes even at moderate to high dosages.

The total sum of these cognitive components regardless of the setting generally includes:

Visual effects:

Enhancements

2C-T-2 presents a full and complete array of possible visual enhancements which generally includes:

Distortions

2C-T-2 presents a full and complete array of possible visual distortions which generally includes:

Geometry

The visual geometry that is present throughout this trip can be described as somewhat similar in appearance to that of Ayahuasca, Psilocin, and 4-ACO-DMT, with mystical and shamanic undertones which combine with synthetic digital undertones reminiscent of LSD or 2C-E. 2C-T-2’s geometry can be comprehensively described through its variations as intricate in complexity, abstract in form, organic but somewhat synthetic in style, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, rounded in edges, large in size, fast in speed, smooth in motion, mostly angular in corners, immersive in depth and consistent in intensity. The visuals have a contradictory “natural” and “synthetic” feel to them which is reminiscent of DOC or 2C-P. Higher dosages are more likely to result in states of Level 8B visual geometry, but may also lead into Level 8A visual geometry (as with 2C-T-7).

Hallucinatory states

2C-T-2 produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the phenethylamine family. These effects include:

  • Transformations
  • External hallucinations - In comparison to other psychedelics such as Ayahuasca, 2C-T-2 is very high in external hallucinations. This particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact manifested as dense solidified geometric matter or physical objects of imagined concepts. They are more common within dark environments and can be described as external in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.
  • Internal hallucinations - In comparison to other psychedelics such as LSD, 2C-T-2 is very high in hallucinations embedded within visual geometry. This particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.

Auditory effects:

The auditory effects of 2C-T-2 are more common in their occurrence than many more commonly used psychedelics and exhibit a full range of effects which commonly includes:

Physical Health Effects, Potential Addiction and Tolerance:

The toxicity and long term health effects of recreational 2C-T-2 use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 2C-T-2 is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried 2C-T-2 within the psychedelic community suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).

There is no current data for the LD50 of 2C-T-2, but it is thought to be high.

2C-T-2 does not seem to be physically addictive and many users experience a self-regulating quality, especially due to the physical manifestations of its effects. There seems to be a tolerance build up when used consecutively multiple days in a row which requires one to double their dosage each time to achieve the same effects.

If 2C-T-2 does have MAOI effects, this could indicate that 2C-T-2 is more likely to induce serotonin syndrome, especially at high dosages, than other serotonergic hallucinogens. This may make it dangerous to combine with certain substances such as MDMA, AMT, Ayahuasca or any substance which releases neurotransmitters such serotonin or those with similar pharmacological effects.

Legal issues:

  • UK: 2C-T-2 is a Class A substance making it illegal to possess, manufacture, or import.
  • USA: 2C-T-2 is a Schedule 1 drug in the USA, making it illegal to possess, manufacture, or import.
  • Australia: 2C-T-2 is illegal in Australia as of 2005.
  • Belgium: 2C-T-2 was added to the list of illegal psychotropic substances on Nov 8, 2004.
  • Brazil: 2C-T-2 is illegal in Brazil as of Feb 18, 2014.
  • Denmark: 2C-T-2 was added to category B of the controlled substances list on August 23, 2003. 
  • E.U.: EU Council published an order on Dec 6 2003, asking all member states to control 2C-I, 2C-T-2, 2C-T-7, and TMA-2.
  • Germany: The drug is on list I / highest level of control, making it unable to be prescribed, manufactured, or possessed as of Oct 7, 1998.
  • Italy: 2C-T-2 was added to the “Tabella 1” in a Jan 11, 2005 Ministry of Health statement.
  • Japan: 2C-T-2 is controlled as a “Designated Substance” (Shitei-Yakubutsu) by the Pharmaceutical Affairs Law, making it illegal to possess or sell
  • Netherlands: It was classified as an unregistered pharmaceutical as of April 12, 1999. Unlicensed manufacture, sale, import, trade and possession of this substance can be prosecuted.

Conclusion:

In conclusion, 2C-T-2 offers incredible depth and a full spectrum of deep psychedelic effects with a cognitive head space that’s closer to a tryptamine psychedelic than many other phenylethylamines. The nausea and physical body load is very intense in proportion to 2C-T-7 and other phenylethylamines, which may be very undesirable to some, however it is still completely worthy of its position within the magical half dozen.

This substance breakdown was written in collaboration with PsychonautWiki admin Cocoanatta. For a more detailed breakdown please click the here.

12 notes
October 25th, 2014 at 9:22PM

bk-MDMA, broken down and described

Dosage (oral):

Threshold : 60mg
Light : 100 - 150mg
Common : 150 - 250mg
Strong : 200 - 300mg

Duration (oral):

Total : 3 - 5 hours
Onset : 20 - 60 minutes
Peak : 60 - 90 minutes
Offset : 60 - 120 minutes
After effects : 1 - 6 hours

Methylone (also known as M1, 3,4-methylenedioxy-N-methylcathinone, MDMC and bk-MDMA) is an entactogen and stimulant of the phenethylamine, amphetamine and cathinone classes. It was first synthesized by chemists Peyton Jacob III and Alexander Shulgin in 1996 for potential use as an antidepressant.

This compound is often used as a substitute for MDMA due to its similar range of subjective effects. However, in spite of behavioral and pharmacological similarities between methylone and MDMA, the observed subjective effects of both drugs are not completely identical. Alexander Shulgin wrote of the former:

"Methylone has almost the same potency of MDMA, but it does not produce the same effects. It has an almost antidepressant action, pleasant and positive, but not the unique magic of MDMA."

"Methylone" is also a trademarked brand name for an injectable form of methylprednisolone, a corticosteroid hormone used to treat arthritis and severe allergic reactions; hence, methylone may be confused with it.

In terms of its chemistry, 3,4-methylenedioxy-N-methylamphetamine is part of the phenethylamine, cathinone and amphetamine families. There is a methylenedioxy ring attached to carbons R3 and R4, as well as methyl chains at Rα and RN. Methylone is a close structural analog of MDMA, differing by the addition of a β-ketone group attached to the beta position of the amine chain.

In terms of its pharmacology, methylone acts as a mixed reuptake inhibitor/releasing agent of serotonin, norepinephrine, and dopamine. These are the neurotransmitters in charge of pleasure, motivation and focus. This is done by inhibiting the reuptake and reabsorption of the neurotransmitters after they have performed their function of transmitting a neural impulse, essentially allowing them to accumulate and be reused, causing physically stimulating and euphoric effects.

In comparison to MDMA, it has approximately 3x lower affinity for the serotonin transporter, while its affinity for the norepinephrine and dopamine transporters is similar. Notably, methylone’s affinity for the vesicular monoamine transporter 2 (VMAT2) is about 13x lower than that of MDMA. The results of these differences in pharmacology relative to MDMA are that methylone is less potent in terms of dose, has more balanced catecholaminergic effects relative to serotonergic, and behaves more like a reuptake inhibitor like methylphenidate than a releaser like amphetamine; however, methylone still has relatively robust releasing capabilities.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects:

The physical effects of methylone can be broken down into seven components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Spontaneous tactile sensations - The “body high” of methylone can be described as a moderate to extreme euphoric tingling sensation that encompasses the entire body. It is capable of becoming overwhelmingly pleasurable at higher dosages. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
  • Stimulation - In terms of its effects on the user’s physical energy levels, methylone is commonly considered to be extremely stimulating and energetic. This encourages activities such as running, climbing and dancing in a way that makes methylone a popular choice for musical events such as festivals and raves. The particular style of stimulation which methylone presents can be described as forced. This means that at higher dosages, it becomes difficult or impossible to keep still as jaw clenching, involuntarily bodily shakes, and vibrations become present, resulting in an extreme unsteadiness of the hands and a general lack of motor control.
  • Vibrating vision - At high dosages, a person’s eyeballs may even begin to spontaneously wiggle back and forth in a rapid motion, causing the vision to become blurry and temporarily out of focus— a condition known as nystagmus.
  • Dehydration - Feelings of dry mouth and dehydration are a universal experience with methylone; this effect is a product of an increased heart rate and an extreme motivation to engage in strenuous physical activities. While it is important to avoid becoming dehydrated, especially when out dancing in a hot environment, there have been a number of users suffering from water intoxication through over-drinking so it is advised that users simply sip at water and never over-drink.
  • Difficulty urinating - Higher doses of methylone result in an overall difficulty when it comes to urination. This is an effect that is completely temporary and harmless, due to methylone’s promotion of the release of anti-diuretic hormone (ADH). ADH is responsible for regulating urination. This effect can be lessened by simply relaxing, but can be significantly relieved by placing a hot flannel over the genitals to warm them up and encourage blood flow.
  • Loss of temperature regulation
  • Tactile enhancement

Cognitive effects:

The cognitive effects of methylone can be broken down into six components all of which progressively intensify proportional to dosage. The general head space of methylone is described by many as one of extreme mental stimulation, feelings of love or empathy and powerful euphoria. It contains a large number of typical psychedelic, entactogenic and stimulant cognitive effects.

The most prominent of these cognitive effects generally include:

  • Euphoria - Strong emotional euphoria and feelings of happiness are present within methylone and are likely a direct result of serotonin and dopamine release. In comparison to MDMA, it is closer in effects to that of the euphoria felt within amphetamine and mephedrone.
  • Empathy, love and sociability enhancement - Although distinct and powerful in its effects, this particular feeling is less pronounced and therapeutic when compared to that of MDMA. It can be described as less forceful and more internal in its manifestation, resulting in feelings of love and empathy that are not necessarily felt as essential to express to others.
  • Time distortion - Strong feelings of time compression are common within methylone and speed up the experience of time quite noticeably.
  • Unity and interconnectedness - Experiences of unity, oneness and interconnectedness between levels 2 - 3 are common within methylone. This component most consistently manifests itself at high dosages within large crowds at raves and musical events in the form of “becoming one with the crowd.”
  • Thought acceleration
  • Mindfulness

Physical Health Effects, Potential Addiction and Tolerance:

The toxicity and long term health effects of recreational methylone use does not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because methylone is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried methylone suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).

Tolerance develops rapidly with repeated usage, so periods of extended use require increasing doses of the drug in order to achieve the same effect. Addiction is a serious risk with heavy recreational use of any stimulant where compulsive redosing is common.

Legal Issues:

  • Netherlands: In the Netherlands, methylone is covered under the medicine act. Because methylone is not registered officially, as such, it is forbidden to trade in methylone.
  • New Zealand: In New Zealand, although methylone is not explicitly scheduled and falls outside the strict definitions of an “amphetamine analogue” in the Misuse of Drugs Act, it is considered to be “substantially similar” to methcathinone and is thus considered by law enforcement authorities to be a Class C illegal drug.
  • United Kingdom: In the UK, methylone has been illegal since the 16/04/2010 revision of the misuse of drugs act.
  • Sweden: Methylone has been listed as a schedule I narcotic in Sweden as of Oct 1 of 2010.
  • Canada: Although not listed as a Schedule 1 substance, Health Canada reports that methylone falls under the scheduling as an analogue of amphetamine. However, Methylone bears the exact chemical difference between amphetamine and cathinone; cathinone is listed as not being an analogue of amphetamine leading to imply that methylone is unscheduled in Canada.
  • United States: As of October 21, 2011 the DEA has issued an emergency ban on methylone. It is illegal to possess and distribute.

Conclusion:

In conclusion, although bk-MDMA is similar to MDMA in high doses, its euphoria is directed inwards rather than forcing the user to project their empathy and love onto others. The dosage is much higher than MDMA in comparison, and it’s a more complex experience due to its different receptor efficacies; there is not simply serotonin happiness, but dirty stimulation too.
This substance breakdown was written through collaboration between PsychonautWiki contributors Pjosepherum, Josikins and Oscarette. The full article, including references, is available here.

39 notes
September 21st, 2014 at 9:48PM

5-MeO-DMT, broken down and described

image

Dosage (smoked)
Threshold : 1 - 2 mg
Light : 2 - 5 mg
Common : 5 - 10 mg
Strong : 10 - 20 mg
Heavy : 20mg +

Duration (smoked)
Total duration : 30 minutes
Onset  : 0 - 1 mins
Peak : 1 - 15 minutes
Come down : 3 - 5 mins
After effects : 15 - 60 mins

Dosage (insufflated)
Threshold : 3 - 5 mg
Light : 5 - 10 mg
Common : 8 - 15 mg
Strong : 10 - 25 mg
Heavy : 25mg+

Duration (insufflated)
Total duration : 2 - 3 hours
Onset : 1 - 10 mins
Peak : 30 - 60 mins
Come down : 30 - 60 mins
After effects : 1 - 3 hrs

5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine) is a powerful psychedelic tryptamine. It is found in a wide variety of plant species, and a single psychoactive toad species. Like its close relatives DMT and bufotenin (5-HO-DMT), it has been used as an entheogen by South American shamans for thousands of years. In modern times, however, it is primarily acquired in its pure form through the use of online research chemical vendors.

When used as a drug in its purified form, 5-MeO-DMT is vaporized, insufflated, or injected and is active at a dose of as little as 2 mg. 5-MeO-DMT is active orally when taken with an MAOI, but according to numerous reports this combination is extremely unpleasant and has a strong body load.

In terms of its chemistry, 5-MeO-DMT is made up of a tryptamine backbone, with a methoxy group substituted onto carbon R5 and two methyl groups substituted onto the nitrogen RN1 and RN2. 5-MeO-DMT is a methoxy derivative of DMT. It is also the O-methyl analogue of bufotenin (5-HO-DMT) and occurs in many organisms alongside of this compound.

In terms of its pharmacology, 5-Meo-DMT’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. Specifically, this molecule shows high affinity for the 5-HT2 and 5-HT1A subtypes. Additional mechanisms of action such as reuptake inhibition of neurotransmitters such as serotonin, noradrenaline and dopamine are involved also.This can result in 5-MeO-DMT becoming dangerously toxic when combined with MAOIs, RIMAs, SSRIs stimulants or any substance which acts as a releasing agent or reuptake inhibitor of neurotransmitters.

5-MeO-DMT is O-demethylated by polymorphic cytochrome P450 2D6 (CYP2D6) to an active metabolite, bufotenin.

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical Effects:

The physical effects of 5-MeO-DMT can be broken down into ten components all of which progressively intensify proportional to dosage. In comparison to its often relatively mild accompanying cognitive and visual effects, 5-MeO-DMT seems to have by far the most proportionally intense and overwhelming physical sensations found within the known psychedelic experience. These individual components are complex, overwhelming and equally capable of being interpreted as either extremely pleasurable or uncomfortable.

Cognitive Effects:

The most prominent of 5-MeO-DMT’s cognitive effects generally include:

Visual effects:

The visual effects of 5-MeO-DMT can be broken down into five components all of which progressively intensify proportional to dosage. In comparison to its consistently overwhelming and intense accompanying cognitive and physical effects, 5-MeO-DMT seems to have some of the most proportionally underwhelming visual effects found within the known psychedelic experience.

  • Visual acuity enhancement and Visual acuity suppression - 5-MeO-DMT is equally capable of both decreasing and increasing visual acuity. The outcome of which effect will manifest seems to be chosen almost entirely at random and is largely setting dependent.
  • Colour enhancement
  • Colour shifting
  • Drifting (Morphing, Breathing, Melting, Flowing) - In comparison to other psychedelics, this effect can be described as identical to DMT in its style, highly detailed, slow and smooth in motion and static in appearance.
  • Geometry - The visual geometry that is present throughout this trip does not usually occur and never extends beyond level 7 at its highest state. It is very similar to DMT although significantly smaller in size and more likely to manifest in darkness or without distractions. In terms of appearance, it can be comprehensively described through its variations as intricate in complexity, abstract in form, equally organic and digital in feel, structured in organization, brightly lit, multicoloured in scheme, glossy in shading, equal in sharp and soft edges, small in size, fast in speed, smooth in motion, equal in rounded and angular corners, immersive in depth and consistent in its intensity.

Auditory effects:

The auditory effects of 5-MeO-DMT are common in their occurrence and exhibit a full range of effects which generally include:

Natural sources:

Colorado River toad: The Colorado River toad (Incilius alvarius), also known as the Sonoran Desert toad, is a psychoactive toad found in northern Mexico and the southwestern United States. Its skin and venom contain 5-MeO-DMT and bufotenin.

The toad’s primary defense system are glands that produce a poison that may be potent enough to kill a grown dog. These parotoid glands also produce the 5-MeO-DMT and bufotenin for which the toad is known. Fresh venom can easily be collected from these glands without harm to the toad. To do this, obtain a flat glass plate or any other smooth, nonporous surface of at least 12-inches square and hold the toad in front of the plate (which is fixed in a vertical position). When the desert toad is stroked near the parotid glands in the neck region, there is a squirting out of this venom. When it is allowed to dry on a hard surface it takes on the texture of rubber cement. It contains up to 15% 5-MeO-DMT, as well as N-methyl-5-methoxytryptamine, 5-MeO-NMT and Bufotenine, which have their own entries. In this manner, the venom can be collected on the glass plate, free of dirt and liquid released when the toad is handled.

Physical Health Effects, Potential Addiction and Tolerance:

The toxicity and long term health effects of recreational 5-MeO-DMT use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. Anecdotal evidence from people within the psychedelic community who have tried 5-MeO-DMT suggests that although physically intense, this substance is well tolerated and physically benign just like other tryptamines. There are no known negative health effects attributed to trying this substance at low or heavy dosages and it has a long history of usage dating back thousands of years.

Deaths from 5-MeO-DMT are rare but, as a powerful monoamine reuptake inhibitor, injury can occur when excessive doses are taken or when taken with drugs such as MAOIs, RIMAs, stimulants and any substance which act as a releasing agent or reuptake inhibitor of neurotransmitters such as serotonin and dopamine. This has resulted in well documented deaths that are easily avoidable and could have been otherwise prevented.

There is a strong tolerance gained after a single dosage of this compound. This diminishes effects greatly if one tries to redose but returns to base line levels within 24 hours.

Legal issues:

  • Denmark: As of December 1, 2004, 5-MeO-DMT was legally restricted to “medical or scientific purposes”.
  • Gemany: As of December 1, 2004, 5-MeO-DMT was legally restricted to “medical or scientific purposes”.
  • Greece: 5-MeO-DMT became a controlled substance in Greece on February 18, 2003 [EU Legal Database].
  • New Zealand: 5-MeO-DMT is Schedule I (Class A) in New Zealand.
  • Sweden: Sveriges riksdags health ministry Statens folkhälsoinstitut classified 5-MeO-DMT as “health hazard” under the act Lagen om förbud mot vissa hälsofarliga varor (translated “Act on the Prohibition of Certain Goods Dangerous to Health”) as of Oct 1, 2004, in their regulation SFS 2004:696 listed as 5-metoxi-N,N-dimetyltryptamin (5-MeO-DMT), making it illegal to sell or possess.
  • Switzerland: 5-MeO-DMT is Schedule I in Switzerland.
  • Romania: 5-MeO-DMT is illegal in Romania since February 2010.
  • USA: 5-MeO-DMT was added to Schedule I, effective January 19, 2011. This means it is illegal to manufacture, buy, possess, or distribute (sell, trade or give) without a DEA license.

Conclusion:

In conclusion, 5-MeO-DMT is an A-Typical psychedelic which although interesting, remains very consistent and repetitive in comparison to other tryptamines such as DMT itself. It is worth trying for the sheer physical intensity and euphoria of it but I would not recommend this substance to anybody who is looking to experience genuine psychedelia.

This substance breakdown was written through collaboration between PsychonautWiki contributors Pjosepherum, Josikins and Oscarette. The full article is available here.

70 notes #5meodmt #5-meo-dmt #dmt #psychedelics #psychedelic #research chemicals #psychonaut #i am so high lol
August 23rd, 2014 at 12:23AM

☯ ♡ ∞ ♡ ☯

Today marks three years since the start of DEIS. We would like to thank each and every one of you for the balls you have tripped, your support and your contributions. Much love to all of you!!! ♡ ♡ ♡ (• ε •)

Sorry for the lack of new content around here recently, you can be expecting many posts and updates very soon. In the mean time, for frequent updates, an active community and a far superior website, please visit our ongoing project www.PsychonautWiki.org

26 notes #the world is a beautiful place and i am no longer afraid to die
August 6th, 2014 at 11:54PM

MDAI, broken down and described

image

Dosage (oral):

Threshold : 20 - 30mg
Light : 60 - 100mg
Common : 100 - 175mg
Strong : 175 - 300+mg

Duration (oral):
Onset : 20 - 70 minutes
Peak : 3 - 5 hours
Coming down : 3 - 4 hours
After effects : 24 hours

MDAI (5,6-Methylenedioxy-2-aminoindane) is a drug developed in the 1990s by a team led by David E. Nichols at Purdue University. It acts as a non-neurotoxic and highly selective serotonin releasing agent (SSRA) which produces entactogen effects in humans similar to that of MDMA.

In terms of its chemistry, the chemical structure of MDAI is indirectly derived from that of the illicit drug MDA, but the alpha-methyl group of the alkylamino amphetamine side chain has been bound back to the benzene nucleus to form an indane ring system. This changes its pharmacological properties substantially.

In terms of its pharmacology, MDAI has been shown to inhibit the reuptake of serotonin, dopamine, and norepinephrine. This demonstrates that MDAI has selective affinity for the serotonin receptor. Studies show that the brains of animals treated with MDAI have greater extracellular concentrations of monoamine neural transmitters, most significantly serotonin. This result indicates that MDAI is a potent releaser of serotonin while effectively inhibiting the reuptake of serotonin. For comparison, MDAI is similar in potency with releasing serotonin to MDA but significantly less potent than MDMA.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects may rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical Effects:

The physical effects of MDAI can be broken down into seven components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Euphoria
  • Enhancement of touch
  • Sedation - The biggest difference between MDAI and MDMA is that due to a comparative lack of dopamine reuptake inhibition, MDAI primarily results in moderate sedation and therefore discourages physical activities such as running, dancing or climbing.
  • Spontaneous tactile sensations - The “body high” of MDAI can be described as a moderate to extreme euphoric, soft and warm tingling sensation that encompasses the entire body. It is capable of becoming overwhelmingly pleasurable at higher dosages. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
  • Dehydration - Feelings of dry mouth and dehydration are a universal experience with MDAI; this effect is a product of an increased heart rate and an extreme motivation to engage in strenuous physical activities. While it is important to avoid becoming dehydrated, especially when out dancing in a hot environment, there have been a number of users suffering from water intoxication through over-drinking so it is advised that users simply sip at water and never over-drink.
  • Vibrating vision - At high dosages, a person’s eyeballs may even begin to spontaneously wiggle back and forth in a rapid motion, causing the vision to become blurry and temporarily out of focus— a condition known as nystagmus.

Cognitive Effects:

The cognitive effects of MDAI can be broken down into four components all of which progressively intensify proportional to dosage. The general head space of MDAI is described by many as one of euphoria and feelings of love or empathy. It contains a number of typical entactogenic cognitive effects.

The most prominent of these cognitive effects generally include:

  • Euphoria - Strong emotional euphoria and feelings of happiness are present within MDAI and are a direct result of serotonin and dopamine release.
  • Increased empathy, love and sociability - This particular effect is equally as pronounced, powerful and therapeutic as that of MDMA or 2C-B. It is the most obvious and noticeable effect within any MDAI experience and dominates the head space.
  • Acceleration of thought
  • Mindfulness

Visual effects:

The visual effects of MDAI only occur at higher dosages and are subtly psychedelic. These generally include:

Physical Health Effects, Potential Addiction and Tolerance:

MDAI and other similar drugs have been widely used in scientific research, as they are able to replicate many of the effects of MDMA but without causing the neurotoxicity which may be associated with MDMA and some related drugs. No tests have been performed on cardiovascular toxicity.

There is currently no scientific data on the lethal dosage of MDAI within human beings but it is thought to be high in comparison to its active dosage. Due to its action as a serotonin reuptake inhibitor, overdoses of this substance would likely result in acute or even fatal serotonin syndrome.

The tolerance to MDAI builds up with repeated usage in much the same way that MDMA does. There does not seem to be any addictive potential but long term usage could potentially lead onto it.

Legal issues:

MDAI is currently a legal grey area world wide and freely available through the use of online research chemical vendors. This does not mean that you are guaranteed to be immune from legal prosecution should you be found in possession of this substance as it is likely to vary from country to country.

Conclusion:

In conclusion, MDAI is an extremely interesting alternative to MDMA due to its lack of neurotoxic effects and minimal dopamine reuptake inhibition. I would suggest this compound to anybody who wishes to experience the profound therapeutic entactogenic effects of MDMA without the stimulation or neurotoxicity. I would recommend the use of 5-HTP serotonin supplements the day after heavy MDAI usage to further mitigate its unlikely adverse effects .

This substance breakdown was written through collaboration between PsychonautWiki administrators Josikins and Oscarette. The full article is available here.

21 notes
August 4th, 2014 at 10:32PM

4-AcO-MET, broken down and described

image

Dosage (oral):

Threshold : 5 - 10mg
Light : 10 - 20mg
Common : 20 - 30mg
Strong : 30 - 40mg
Heavy : 40mg+

Duration (oral):

Total Duration : 4 - 6 hours
Onset : 20 - 60 minutes
Peak : 1 - 2 hours
Coming down : 2 - 4 hours
After effects : 1 - 5 hours

4-Acetoxy-MET (4-Acetoxy-N-methyl-N-ethyltryptamine, metacetin or 4-AcO-MET) is a psychedelic tryptamine thought to be a serotonergic psychedelic similar to 4-AcO-DMT, LSD and DMT. Its molecular structure and pharmacological effects resemble those of the tryptamine psilocin which is the primary psychoactive chemical in magic mushrooms.

In terms of its chemistry, 4-AcO-MET is the acetate ester of 4-HO-MET. It is a substituted tryptamine with an acetoxy group at the 4 position of the cyclohexane ring, an ethyl chain and a methyl chain on the nitrogen position.

It is hypothesized that this compound is quickly hydrolyzed into the free phenolic 4-HO-MET, although human studies concerning the metabolic fate of this drug are lacking. This would explain a somewhat similar experience in their subjective effects. This is similar to how 4-AcO-DMT is thought to be deacetylated to 4-HO-DMT during first pass metabolism and subsequent passes through the liver.

In terms of its pharmacology, 4-AcO-MET’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

4-AcO-MET is commonly sold as a research chemical through the use of online vendors. In terms of its effects, it can be vaguely described as somewhat more synthetic in feel to that of other tryptamines but with a shorter duration.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical Effects:

The physical effects of 4-AcO-MET can be broken down into three components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Spontaneous tactile sensations - The “body high” of 4-AcO-MET can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
  • Sedation - In terms of its effects on the physical energy levels of the tripper, 4-AcO-MET is considered by most to be relaxing, stoning and mildly sedating. This sense of sedation is often accompanied by compulsive yawning.
  • Nausea

Cognitive Effects:

The cognitive effects of 4-AcO-MET are described by many as somewhat relaxing, yet face-paced in style with similarities to psychedelics such as LSD or 2C-B which tend to be cognitively energetic and stimulating. The drug contains a large number of typical and unique psychedelic cognitive effects.

The most prominent of these typical effects generally include:

Visual effects:

Enhancements

4-AcO-MET presents a full and complete array of possible visual enhancements which generally includes:

Distortions

As for visual distortions and alterations, the effects experienced are detailed below:

Geometry

The visual geometry that is present throughout this trip can be described as somewhat similar in appearance to that of Psilocin, 4-AcO-DMT and 4-HO-MiPT but with far stronger synthetic digital undertones reminiscent of LSD or 2C-B. 4-AcO-MET can be comprehensively described through its variations as intricate in complexity, abstract in form, equally synthetic and organic in style, structured in organization, extremely brightly lit and multicoloured in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, angular in corners, unimmersive in depth and consistent in intensity. The visuals have a contradictory “natural” and “synthetic” feel to them which is reminiscent of both LSD and and Psilocybin. Higher dosages are significantly more likely to result in states of Level 8A visual geometry over Level 8B.

Hallucinatory States

4-AcO-MET and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. These effects generally include:

Auditory Effects:

The auditory effects of 4-AcO-MET are common in their occurrence and exhibit a full range of effects which commonly include:

Physical Health Effects, Potential Addiction and Tolerance:

The toxicity and long term health effects of recreational 4-AcO-MET use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 4-AcO-MET is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried 4-AcO-MET within the psychonaut community suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).

There is no current data for the LD50 of 4-AcO-MET, but it is thought to be high.

4-AcO-MET does not seem to be physically addictive and many users experience a self-regulating quality. There seems to be a tolerance build up when used consecutively multiple days in a row which requires one to double their dosage each time to achieve the same effects.

Legal issues:

USA: 4-Acetoxy-MET is unscheduled in the United States, but the possession and sale of 4-Acetoxy-MET could possibly be prosecuted under the Federal Analog Act if intent to consume can be proven because of its structural similarities to psilocin.

Conclusion:

4-AcO-MET induced a trip which was distinctively different from that of other more commonly used research chemicals that I have tried. The colourful, digital and synthetic geometry was in sharp contrast to that of 4-AcO-DMT, psilocybin and ayahuasca. This combined with its shorter duration and equally insightful headspace made for a therapeutic and recreational experience somewhat halfway between that of mushrooms and LSD.

This substance breakdown was written through collaboration between PsychonautWiki contributors Josikins and Oscarette. The full article is available here.

22 notes #4ACOMET #4-ACO-MET #DMT #psychedelics #i love you all #trippy #psychonaut #psychonautics #psychonauts