Disregard Everything I Say

Dosage (oral)

Threshold : 3-5mg
Light : 5-8mg
Common : 8-14mg
Strong : 14-20mg
Heavy : 20-25+mg

Duration (oral)

Total Duration : 5 - 8 hrs
Onset : 20 - 60 mins
Initial effects : 30 - 45 mins
Peak : 1 - 2 hrs
Coming down : 1 - 2 hrs
After effects : 1 - 8 hrs

Dosage (smoked)

Threshold : 5-8mg
Light : 8-10mg
Common : 10-15mg
Strong : 15-20mg
Heavy : 20-25+mg

Duration (smoked)

Total Duration : 5 - 8 hrs
Onset : 20 - 60 mins
Initial effects : 30 - 45 mins
Peak : 1 - 2 hrs
Coming down : 1 - 2 hrs
After effects : 1 - 8 hrs

5-MeO-MIPT, or 5-methoxy-N-methyl-N-isopropyltryptamine also known as “Moxy” is a psychedelic and entactogenic drug in a class of compounds commonly known as tryptamines. It is the N-methyl-N-isopropyl homologue of the well know psychedelic 5-MeO-DMT. It has structural and pharmacodynamic properties similar to the drugs 5-MeO-DiPT, DiPT, and MiPT.

This substance has no history of human usage prior to the 1985 publication of its synthesis and pharmacology in the Journal of Medicinal Chemistry by Repke, Grotjahn & Shulgin. In modern times it is used as a recreational drug and an entheogen, rarely sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors.

The mechanism that produces the hallucinogenic and entactogenic effects of 5-MeO-MiPT is thought to result primarily from 5-HT2A receptor agonism, although additional mechanisms of action such as inhibition of MAO may also be involved.

The 5-MeO-MiPT experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe…

Physical effects:

The body high of 5-MeO-MIPT can be described as a pleasurable, warm, soft and all encompassing glow. There is also a cold, sharp tingling sensation that is manifested spontaneously at different unpredictable points throughout the trip but for others it can maintain a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.

In terms of its effects on the physical energy levels of the tripper, 5-MeO-MIPT can be both sedating and stimulating. The physical energy levels seem to manifest themselves in waves in an unpredictable pattern. This seems to be partially setting dependant and during physically strenuous situations such as running or dancing it can become stimulating and energetic. In contrast however, in calm environments such as darkened rooms with comfortable seating it can become relaxing, peaceful and even moderately sedating.

As the tripper begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, but passes once this over or the trip begins to fully set in. In comparison to other psychedelics such as psilocin, LSD, and 2C-E, this could actually be very considered very mild in its intensity. In comparison to 5-MeO-DIPT, 5-MeO-MIPT has a much lower tendency to trigger unpleasant physical reactions and has been described as much less physically stimulating.

Cognitive effects:

The head space of 5-MeO-MIPT is described by many as one which is both insightful and moderately relaxing, but at some points quite stimulating. This manifests itself as two different styles of head space that depend both on the setting and the way in which this drug manifests its self in varying waves. For example, when taken with others these effects seems to have very strong entactogenic effects, which can become quite stimulating. These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA or 2C-B but still are prove stronger and more consistent than most other psychedelics of any class, proving to be capable of providing long lasting therapeutic effects.

When this substance is taken alone however, the entacogenic effects are replaced with typical psychedelic introspection. These two alternate sets of present cognitive effects seem to be a prominent stimulation coupled with a relaxing clarity, shifting into each other based on the users current current mind state and external environmental factors.

Along side of these two alternate sets of effects, this substance produces a large number of general psychedelic cognitive effects. The most prominent of these include,

• Introspection
• Acceleration of thought
• Connectivity of thought
• Enhancement of current mind state
• Removal of cultural filter
• Feelings of fascination and awe
• Conceptual thinking
• Ego suppression, loss and death
• Time distortion
• Communication with the subconscious
• Deja-vu
• Entactogenic effects (increased empathy and sociability)

Visual effects:

Enhancements,

5-MeO-MIPT presents a complete array of possible visual enhancements which generally includes,

• Increased visual acuity
• Enhancement of colours
• Enhanced pattern recognition

Distortions,

As for visual distortions and alterations, these generally include,

• Visual drifting (melting, breathing, warping and flowing) - In comparison to other psychedelics this effect can be described as highly detailed, slow and smooth in motion and static in appearance. 
• Tracers
• After images
• Texture repetition
• Colour shifting
• Scenery slicing

Geometry,

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of Psilocin, 4-AcO-DMT or Ayahuasca than that of LSD or 2C-B. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, equal in blurred and sharp edges and equal in rounded and angular corners. At higher dosages they are significantly more likely to result in states of level 7B visual geometry over level 7A.

In terms of their manifestation they are progressive in nature and continuously self complexify in settings with little or no visual input and disturbances. For example, darkness will cause the geometry to progressively intensify but this can immediately be reset back down to base level by simply turning on a bright light or actively performing a physical task which requires any level of concentration.

Hallucinatory states,

5-MeO-MIPT is capable of producing level 1 - 4 hallucinatory states. These effects include,

• Transformations
• Imagery
• Hallucinations - this particular effect commonly contains hallucinations with scenarios, landscapes, sceneries and settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively religious, spiritual, mystical or transcendental nature in their overall theme.

Auditory effects:

The auditory effects of 5-MeO-MIPT are common in their occurrence and exhibit a full range of effects which commonly includes,

• Auditory enhancements
• Auditory distortions
• Auditory hallucinations

Differences in methods of consumption:

This substance can be taken via oral ingestion or it can be smoked. When ingested orally the experience puts more of an emphasis on visual effects but can be broken up into two stages, the first half of the trip feels stimulating and entactogenic and the second half feelsmore similar to a traditional typtamine psychedelic.

If smoked however these stages of experience are not present and the experience places more of an emphasis on physically and cognitively stimulating effects accompanied by subtle and mild changes in visual perception.

Health effects, addiction potential and tolerance:

The toxicity of 5-MeO-MiPT is not known but as with all research chemicals doses should be carefully weighed on an accurate milligram scale and users should take extreme caution to work their way up from thresh hold dosages. There are many reports of vasoconstriction and uncomfortable increases in heart rate and this should be taken into account.

5-MeO-MIPT and MAOIs are a potentially dangerous combination. It is likely that MAOIs could increase the effects of 5-MeO-MIPT unpredictably. Taking this chemical while under the influence of Ayahuasca, harmala alkaloids, AMT and prescription MAOIs such as certain antidepressants is strongly discouraged.

5-MeO-MIPT is not physically addictive, and many users experience a frequency self-regulating quality to the drug. Tolerance seems to be very moderate and does not build up without repeated use over a short period of time.

Legal issues:

• USA: 5-MeO-MIPT is technically not scheduled in the United States, but could be considered an analogue of 5-MeO-DMT and therefore a Schedule I drug.
• UK: 5-MeO-MiPT is a Class A drug in the United Kingdom, as are most ethers of ring-hydroxy tryptamines.
• Romania: 5-MeO-MIPT and other derivatives are illegal in Romania, as of January 2011.
• Japan: 5-MeO-MIPT is controlled as a “Designated Substance” (Shitei-Yakubutsu) by the Pharmaceutical Affairs Law, making it illegal to possess or sell

Conclusion:

5-MeO-MiPT is an extremely interesting and powerful substance and can be considered as the most useful and therapeutic entactogenic experience found with the tryptamine compunds. For those who are familiar with them, the overall effects of this substance can be described as mixture between Ayahuasca, MDMA, Psilocin and 5-MeO-DMT.

This substance effect breakdown was contributed by Encyclopedia Psychonautica admin, Cocoanatta.