Disregard Everything I Say

Dosage (oral)

Threshold : 3-5mg
Light : 5-8mg
Common : 8-14mg
Strong : 14-20mg
Heavy : 20-25+mg

Duration (oral)

Total Duration : 5 - 8 hrs
Onset : 20 - 60 mins
Initial effects : 30 - 45 mins
Peak : 1 - 2 hrs
Coming down : 1 - 2 hrs
After effects : 1 - 8 hrs

Dosage (smoked)

Threshold : 5-8mg
Light : 8-10mg
Common : 10-15mg
Strong : 15-20mg
Heavy : 20-25+mg

Duration (smoked)

Total Duration : 5 - 8 hrs
Onset : 20 - 60 mins
Initial effects : 30 - 45 mins
Peak : 1 - 2 hrs
Coming down : 1 - 2 hrs
After effects : 1 - 8 hrs

5-MeO-MIPT, or 5-methoxy-N-methyl-N-isopropyltryptamine also known as “Moxy” is a psychedelic and entactogenic drug in a class of compounds commonly known as tryptamines. It is the N-methyl-N-isopropyl homologue of the well know psychedelic 5-MeO-DMT. It has structural and pharmacodynamic properties similar to the drugs 5-MeO-DiPT, DiPT, and MiPT.

This substance has no history of human usage prior to the 1985 publication of its synthesis and pharmacology in the Journal of Medicinal Chemistry by Repke, Grotjahn & Shulgin. In modern times it is used as a recreational drug and an entheogen, rarely sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors.

The mechanism that produces the hallucinogenic and entactogenic effects of 5-MeO-MiPT is thought to result primarily from 5-HT2A receptor agonism, although additional mechanisms of action such as inhibition of MAO may also be involved.

The 5-MeO-MiPT experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe…

Physical effects:

The body high of 5-MeO-MIPT can be described as a pleasurable, warm, soft and all encompassing glow. There is also a cold, sharp tingling sensation that is manifested spontaneously at different unpredictable points throughout the trip but for others it can maintain a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.

In terms of its effects on the physical energy levels of the tripper, 5-MeO-MIPT can be both sedating and stimulating. The physical energy levels seem to manifest themselves in waves in an unpredictable pattern. This seems to be partially setting dependant and during physically strenuous situations such as running or dancing it can become stimulating and energetic. In contrast however, in calm environments such as darkened rooms with comfortable seating it can become relaxing, peaceful and even moderately sedating.

As the tripper begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, but passes once this over or the trip begins to fully set in. In comparison to other psychedelics such as psilocin, LSD, and 2C-E, this could actually be very considered very mild in its intensity. In comparison to 5-MeO-DIPT, 5-MeO-MIPT has a much lower tendency to trigger unpleasant physical reactions and has been described as much less physically stimulating.

Cognitive effects:

The head space of 5-MeO-MIPT is described by many as one which is both insightful and moderately relaxing, but at some points quite stimulating. This manifests itself as two different styles of head space that depend both on the setting and the way in which this drug manifests its self in varying waves. For example, when taken with others these effects seems to have very strong entactogenic effects, which can become quite stimulating. These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA or 2C-B but still are prove stronger and more consistent than most other psychedelics of any class, proving to be capable of providing long lasting therapeutic effects.

When this substance is taken alone however, the entacogenic effects are replaced with typical psychedelic introspection. These two alternate sets of present cognitive effects seem to be a prominent stimulation coupled with a relaxing clarity, shifting into each other based on the users current current mind state and external environmental factors.

Along side of these two alternate sets of effects, this substance produces a large number of general psychedelic cognitive effects. The most prominent of these include,

• Introspection
• Acceleration of thought
• Connectivity of thought
• Enhancement of current mind state
• Removal of cultural filter
• Feelings of fascination and awe
• Conceptual thinking
• Ego suppression, loss and death
• Time distortion
• Communication with the subconscious
• Deja-vu
• Entactogenic effects (increased empathy and sociability)

Visual effects:

Enhancements,

5-MeO-MIPT presents a complete array of possible visual enhancements which generally includes,

• Increased visual acuity
• Enhancement of colours
• Enhanced pattern recognition

Distortions,

As for visual distortions and alterations, these generally include,

• Visual drifting (melting, breathing, warping and flowing) - In comparison to other psychedelics this effect can be described as highly detailed, slow and smooth in motion and static in appearance. 
• Tracers
• After images
• Texture repetition
• Colour shifting
• Scenery slicing

Geometry,

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of Psilocin, 4-AcO-DMT or Ayahuasca than that of LSD or 2C-B. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, equal in blurred and sharp edges and equal in rounded and angular corners. At higher dosages they are significantly more likely to result in states of level 7B visual geometry over level 7A.

In terms of their manifestation they are progressive in nature and continuously self complexify in settings with little or no visual input and disturbances. For example, darkness will cause the geometry to progressively intensify but this can immediately be reset back down to base level by simply turning on a bright light or actively performing a physical task which requires any level of concentration.

Hallucinatory states,

5-MeO-MIPT is capable of producing level 1 - 4 hallucinatory states. These effects include,

• Transformations
• Imagery
• Hallucinations - this particular effect commonly contains hallucinations with scenarios, landscapes, sceneries and settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively religious, spiritual, mystical or transcendental nature in their overall theme.

Auditory effects:

The auditory effects of 5-MeO-MIPT are common in their occurrence and exhibit a full range of effects which commonly includes,

• Auditory enhancements
• Auditory distortions
• Auditory hallucinations

Differences in methods of consumption:

This substance can be taken via oral ingestion or it can be smoked. When ingested orally the experience puts more of an emphasis on visual effects but can be broken up into two stages, the first half of the trip feels stimulating and entactogenic and the second half feelsmore similar to a traditional typtamine psychedelic.

If smoked however these stages of experience are not present and the experience places more of an emphasis on physically and cognitively stimulating effects accompanied by subtle and mild changes in visual perception.

Health effects, addiction potential and tolerance:

The toxicity of 5-MeO-MiPT is not known but as with all research chemicals doses should be carefully weighed on an accurate milligram scale and users should take extreme caution to work their way up from thresh hold dosages. There are many reports of vasoconstriction and uncomfortable increases in heart rate and this should be taken into account.

5-MeO-MIPT and MAOIs are a potentially dangerous combination. It is likely that MAOIs could increase the effects of 5-MeO-MIPT unpredictably. Taking this chemical while under the influence of Ayahuasca, harmala alkaloids, AMT and prescription MAOIs such as certain antidepressants is strongly discouraged.

5-MeO-MIPT is not physically addictive, and many users experience a frequency self-regulating quality to the drug. Tolerance seems to be very moderate and does not build up without repeated use over a short period of time.

Legal issues:

• USA: 5-MeO-MIPT is technically not scheduled in the United States, but could be considered an analogue of 5-MeO-DMT and therefore a Schedule I drug.
• UK: 5-MeO-MiPT is a Class A drug in the United Kingdom, as are most ethers of ring-hydroxy tryptamines.
• Romania: 5-MeO-MIPT and other derivatives are illegal in Romania, as of January 2011.
• Japan: 5-MeO-MIPT is controlled as a “Designated Substance” (Shitei-Yakubutsu) by the Pharmaceutical Affairs Law, making it illegal to possess or sell

Conclusion:

5-MeO-MiPT is an extremely interesting and powerful substance and can be considered as the most useful and therapeutic entactogenic experience found with the tryptamine compunds. For those who are familiar with them, the overall effects of this substance can be described as mixture between Ayahuasca, MDMA, Psilocin and 5-MeO-DMT.

This substance effect breakdown was contributed by Encyclopedia Psychonautica admin, Cocoanatta.

Onset : 20 - 60 minutes
Duration : 2 - 6 hours
Normal After Effects : 1 - 8 hours

Ayahuasca is any of various psychoactive infusions prepared from a monoamine oxidase inhibitor (MAOI) such as B. caapi (Harmaline) or a reversible inhibitor of monoamine oxidase A (RIMAs) such as syrian rue (Harmine), taken with a brewed dimethyltryptamine (DMT) containing plant species. There are a large variety of these plants but in western society the most commonly used plants are either Psychotria viridis leaves or Mimosa Hostillis rootbark.

Harmala alkaloids are MAO-inhibiting beta-carbolines. Harmine and harmaline are classed as selective and reversible inhibitors of monoamine oxidase A (MAO-A). This inhibition of MAO-A allows DMT to diffuse unmetabolized past the membranes in the stomach and small intestine, and eventually cross the blood–brain barrier (which, by itself, requires no MAO-A inhibition) to activate receptor sites in the brain. Without RIMAs or an MAOI, DMT would be oxidised (and thus rendered biologically inactive) by monoamine oxidase enzymes in the digestive tract.

Ayahuasca usually comes in the form of a foul tasting brown liquid that has been used by the indigenous tribes of South America since before recorded history. However, it was first discovered by the western world in the 16th century, when Christian missionaries from Spain and Portugal predictably described it as the work of the devil.

Those who undergo the ayahuasca experience report having profound spiritual revelations regarding their purpose on earth, the true nature of the universe as well as deep insight as how to be the best person they possibly can. It is nearly always said that people experience profound positive changes in their life subsequent to consuming ayahuasca. In addition, it is often reported that individuals experience what gaining access to so called “higher spiritual dimensions” and making contact with various autonomous entities who serve to act as guides or healers. 

The Ayahuasca experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe… 

Physical effects:

The body high of ayahuasca can be described as a pleasurable, warm, soft and all encompassing glow. For some it is manifested spontaneously at different unpredictable points throughout the trip but for others it maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.

In terms of its effects on the physical energy levels of the tripper ayahuasca is entirely setting dependent. For example, when taken in social settings with fast paced music or during physically strenuous situations such as running, walking, climbing or dancing it becomes stimulating and energetic. In contrast however, when taken in calm environments such as darkened rooms with comfortable seating it can become relaxing, peaceful and even moderately sedating.

Cognitive effects:

The head space of ayahuasca is described by many as extremely sober and clear headed in its style when compared to other commonly used psychedelics such as LSD or Psilocin. It contains a large number of psychedelic typical and unique cognitive effects.

The most prominent of these typical effects include,

• Introspection
• Acceleration of thought
• Enhancement of current mind state
• Removal of cultural filter
• Feelings of fascination and awe
• Conceptual thinking
• Vocabulary suppression
• Ego suppression, loss and death
• Time distortion
• Deja-vu

Along side of the typical cognitive effects listed above, ayahuasca induces certain states which are seemingly rare or spontaneous within all other psychedelics in a consistent, reproducible and extremely powerful way. These commonly reported unique cognitive effects include,

• Powerful and consistent mindfulness - The term “mindfulness" is used within psychological literature to refer to states which are achieved through the act of practising meditation. This feeling is characterized by a sense of focus on the present moment with a stillness and clarity of mind. Induced mindfulness can occur within any psychedelic but is unique within ayahuasca due to how consistently it is manifested and the way in which it can sustain itself for days, weeks or even months after a single high dose experience. This is an extremely beneficial and therapeutic effect for personal psychological health. In contrast, other more commonly used psychedelics such as LSD and Psilocin tend to induce this effect in a merely spontaneous and temporary form.
• Consistently induced states of unity and interconnectedness - This is an effect is unique within ayahuasca due to how consistently it is manifested as an accompanying effect along side of ego death and occasionally, ego suppression. In contrast, other more commonly used psychedelics such as LSD and Psilocin tend to induce this effect rarely at best.
• Consistent communication with the subconscious - Although I am currently working on it, this specific effect has yet to be fully mapped out by me in a formal level of detail. It can be briefly described however as a literal communication with an internal voice within the mind which claims to be the subconscious. At lower levels this is performed by the subconscious conversing with you through your own thought stream. At higher dosages however it becomes a fully audible voice which is capable of coherent conversation on the same level as the ego and arguably self aware in its own right.
• Sustained dream potentiation - Regular or occassional ayahuasca usage commonly results in extremely vivid, lucid and easy to recollect dreams in the days and weeks after the experience.

It’s worth noting that the overall cognitive positivity or negativity of an ayahuasca trip in psychologically balanced individuals depends greatly on how nauseating or purgative the chosen method of preparation is. For example, paranoia, anxiety, delirium and a difficulty stringing thoughts together often immediately manifest themselves during uncomfortable states of nausea for the inexperienced but remain absent when purge free methods of preparation are used or the user has been accustomed to the purge itself.

Visual effects:

Enhancements,

Ayahuasca presents a complete array of possible visual enhancements which generally includes,

• Increased visual acuity
• Enhancement of colours
• Enhanced pattern recognition

Distortions,

As for visual distortions and alterations, effects experienced are detailed below,

• Visual drifting (melting, breathing, warping and flowing) - In comparison to other psychedelics this effect can be described as highly detailed, slow and smooth in motion and static in their appearance.
• Tracers
• After images
• Texture repetition
• Colour shifting
• Scenery slicing

Geometry,

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of Psilocin than LSD. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, equal in blurred and sharp edges and equal in rounded and angular corners. At higher dosages they are significantly more likely to result in states of level 7B visual geometry over level 7A.

In terms of their manifestation they are progressive in nature and continuously self complexify in settings with little or no visual input and disturbances. For example, darkness will cause the geometry to progressively intensify but this can immediately be reset back down to base level by simply turning on a bright light or actively performing a physical task which requires any level of concentration.

Hallucinatory states,

Ayahuasca and other forms of DMT produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of any other commonly used psychedelic. These effects include,

• Transformations
• Imagery
• Hallucinations - this particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively religious, spiritual, mystical or transcendental nature in their overall theme.

Auditory effects:

The auditory effects of ayahuasca are extremely consistent in occurrence in comparison to that of LSD and psilocin and exhibit a full range of effects which commonly includes,

• Auditory enhancements
• Auditory distortions
• Auditory hallucinations

Health effects, potential addiction and tolerance:

Research has been made showing the relative physical safety of DMT.

Ayahuasca, has been studied by multidisciplinary groups in Brazil and other countries and was shown that in reasonable doses in a careful context, it presents no negative cognitive/psychiatric/physical consequences.

In terms of mental health the very same study showed that users presented elevated levels of happiness and health. Ayahuasca is not physically addictive, and many users experience a frequency self-regulating quality to the drug. This is despite the fact that the substance holds no real tolerance and can be used on a daily basis if it is desired.

As for the harmine or Syrian rue, it is only dangerous when taken in combination with other drugs and it is not necessary to follow a strict tyramine free diet, which is the case with harmaline. So although RIMAs are generally safer than MAOIs, they still have highly dangerous interactions when combined with almost any antidepressant or stimulant, common migraine medications, certain herbs, or even most cold medicines (including decongestants, antihistamines, and cough syrup) as it can cause potentially lethal serotonin syndrome or hypertensive crisis.

Legal issues:

• Internationally, DMT is a Schedule I drug under the Convention on Psychotropic Substances. The Commentary on the Convention on Psychotropic Substances notes, however, that the plants containing it are not subject to international control.
• The legal status in the United States of DMT-containing plants is somewhat questionable. Ayahuasca plants and preparations are legal, as they contain no scheduled chemicals. However, brews made using DMT containing plants are illegal since DMT is a Schedule I drug.
• Religious use in Brazil was legalized after two official inquiries into the tea in the mid-1980s, which concluded that ayahuasca is not a recreational drug and has valid spiritual uses.
• In france, as of 2005 almost every single DMT containing plant that could be used to make Ayahusca is illegal.

Although DMT has been made illegal in almost every country. The common botanical sources for it, however, are still legal pretty much everywhere. You can even freely purchase DMT containing plants from specialized ethnobotanical shops on the internet. Harmine and harmaline, are also generally legal, including most of its ethnobotanically common plant sources. In Canada however harmaline is a Schedule lll drug.

Preparation methods:

Ayahuasca can be prepared in a number of ways using a variety of different plant sources. For the DMT, the most commonly used ingredients are mimosa hostillis rootbark or acacia rootbark. The harmala alkaloids and inhibitors are usually found within syrian rue seeds or Banisteriopsis caapi leaves. All of these are legal to purchase within most countries and freely available through the use of google. 

For the purposes of this article we have developed, linked and listed below 3 formal recipes for both traditional ayahuasca brews and practical modern day equivalents,

• Traditional ayahuasca brew - This method can take up to several hours depending on the desired potency of the brew. It results in a shot glass of foul tasting brown liquid and has a high risk of nausea / purging.
• Ayahuasca fruit smoothie - This method seems absurdly comical in its simplicity and incredible practicality.  I accidentally stumbled upon this method through random experimentation and realized that simply blending small amounts of the wood into a banana smoothie and adding sugar results in a perfectly drinkable (although strangely textured) drink. This can be made within less than ten minutes and results in minimal nausea. It is without exaggeration, the simplest and most practical ayahuasca recipe ever developed.
• Ayahuasca chocolate shredded wheat cupcakes - After realizing that ayahuasca could easily be prepared into a milkshake, further experimentation resulted in cupcake which is surprisingly delicious although very chocolatey. It takes an hour or so in total to make these cakes and contains minimal nausea. They are better used for low to moderate dosages and many people note that they literally taste like normal cupcakes.

Misconceptions:

There appears to be a general consensus among many online psychedelic communities that ayahuasca is simply too powerful for beginners and that even the most experienced of psychonauts should tread lightly. Some people even go as far as saying that you should not undergo the experience without the guidance of a practising shaman and always within a traditional environment.

I would like to use this section of the article to express the opinion that these view points are misinformed and at times, unnecessarily elitist. Providing the user can handle nausea or a purge free preparation method has been used, ayahuasca is the most perfect starter psychedelic in existence and not in any way more overwhelming than LSD or mushrooms. It can also be taken in any number of environments no matter how shamanically inappropriate but as with any psychedelic, it will only take you to its deepest points within silent darkness. 

Reader submitted trip reports:

• 2g Syrian rue + 1g Mimosa Hostillis - These voices are the building blocks of consciousness by Anonymous.
• 3.5g Syrian rue + 30g Mimosa Hostillis brew - flying through a rainbow tunnel by Gregasaurus.
• 3.5g Syrian rue + 50g Mimosa Hostillis - I was trying to engage in sexual intercourse with the personification of Ayahuasca by Gregasaurus.
• 6g mimosa / 2.5 g syrian rue - Best cake I’ve had for a while by Gregasaurus.
• 3g mimosa / 2g syrian rue - I was the Universe’s prophet by Gregasaurus.

Conclusion:

Ayahuasca is by far my favourite psychedelic. It is extremely easy to make and offers a completely different, but amazing style of trip that needs to be taken much more seriously. If I had to choose a single substance for society to base its civilisation around it would be ayahuasca, not LSD and certainly not Alcohol.