Disregard Everything I Say

Dosage
Threshold : 0 - 50 mg
Light : 50 - 100 mg
Common : 100 - 150 mg
Strong : 150 - 200 mg
Heavy : 200 mg+

Duration
Total duration : 6 - 8 hrs

Methoxphenidine (MXP) or 1-[1-(2-methoxyphenyl)-2-phenylethyl]piperidine is a hallucinogenic dissociative compound of the piperdine chemical class. It has similar effects to that of the arylcyclohexylamine and morphinan classes of dissociatives.

It induces a state referred to as “dissociative anesthesia” and is used as a recreational drug. Very little is known about this substance but it has recently become freely available through online research chemical vendors where it is being sold as a designer drug and marketed as a replacement for MXE despite many users reporting it as qualitatively different in its effects and closer to that of DXM. It has yet to be studied within humans in any formal context.

In terms of its chemistry, MXP is classed as a piperdine drug. The piperdine molecule in MXP is attached to a benzene group via two carbon atoms on one side and a methoxybenzene molecule attached to one carbon on the other side. It is usually produced in its freebase form, which is insoluble in water. When consumed orally, the molecule is converted to the hydrochloride salt in the stomach. The HCl salt is reported to raise blood pressure, and peak effects are felt around 2 hours in, whereas the citrate salt has been observed to peak at around 30 minutes with less blood pressure concern. This is the same principal as DXM which is more potent in its citrate salt.

As for its pharmacology, MXP has antagonistic action on NMDA receptors, which leads to anaesthetic and dissociative effects. Although it has not been formally studied, the feelings of physical and emotional euphoria which many users report suggests that it may also have action as a dopamine reuptake inhibitor.

The MXP experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical effects:

The subjective physical effects of MXP are most similar to that of DXM than any other commonly used dissociative. They can be broken down into seven components all of which progressively intensify proportional to dosage. These are described below and generally include:

• Disconnection from tactile input - this results in typical states of progressive physical disconnection but is far more consciously controllable than that of other dissociatives. This allows one to choose how much of their body they are currently aware of and connected to simply by directing their focus towards it even throughout higher states of disconnection and out of body experiences.
• Spontaneous tactile sensations - the MXP body high is a soft, pleasurable vibrating sensation. It can be felt all over the body and progressively intensifies throughout the onset before dissipating once the peak has been reached.
• Suppression of touch - this partially to entirely suppresses one’s own sense of touch, creating feelings of numbness within the extremities. It is responsible for the anaesthetic properties of this substance.
• Physical autonomy
• Loss of motor control - a loss of gross and fine motor control alongside of balance and coordination is prevalent within MXP and becomes especially strong at higher dosages. This means that one should be sitting down before the onset unless they are experienced in case of falling over and injuring oneself.
• Euphoria - this results in feelings of physical euphoria which range between mild pleasure to powerful all encompassing bliss.
• Decreased bodily weight - this creates the sensation that the body is floating and has become entirely weightless. This effect is strangely stimulating and encourages physical activities at low - moderate dosages by making the body feel light and effortless to move.
• Dizziness

Cognitive effects:

The head space of MXP is often described as particularly clear headed even at heavy dosages. It is far more controllable, less disorientating and confusing at dosages of equal subjective intensity to that of MXE, DXM and Ketamine. The cognitive effects of MXP can be broken down into 6 separate subcomponents which are listed and described below:

• Disconnection from consciousness
• Acceleration of thought
• Ego suppression, loss and death
• Time distortion - feelings of time dilation and more time having passed than it actually has are common at moderate to strong dosages.
• Euphoria
• Conceptual thinking

Visual effects:

The visual effects of MXP are unique in comparison to other dissociatives as they do not include open eye visual suppression, geometry or distortions but still remain very powerful at appropriate dosages. The present effects progressively intensify according to dosage and commonly include:

• Disconnection from visual input - this eventually results in the MXP’s equivalent of the famous “K-hole” or more specifically, holes, spaces and voids alongside of level 1 - 4 structures. In comparison to other substances, this effect is unique however as it is far more consciously controllable than that of other dissociatives. It allows one to choose how disconnected they currently are by simply directing their focus towards the external environment even throughout higher states of disconnection and out of body experiences.
• Internal hallucinations - these hallucinatory states can be described as dream like in nature while often containing imagery, landscapes, plots, settings, autonomous entity contact and scenarios. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, mostly unimmersive in style and extremely controllable in their content in a way which allows one to choose what they wish to see.

Auditory effects:

The auditory effects of MXP are common in their occurrence but unlike other more commonly used dissociatives, they are unlikely to suppress or distort auditory input and exhibit a small range of effects which exclusively includes:

• Enhancements

Afterglow:

The afterglow is a feeling that occurs within the 24 hours after the trip itself. It is long lasting and as equally enjoyable as the trip itself to many people. It can be be described in terms of its physical sensation as one of euphoria, rejuvenation, relaxation and a light bounciness. In terms of its mental thought processes however, it can be described as a complete loss of anxiety, feelings of contentedness and an extremely high appreciation for music which dissipates within a day or so after the experience.

Health effects, addiction potential and tolerance:

The toxicity and long term health effects of recreational MXP use does not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because MXP is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried MXP within the community suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).

There is a very strong tolerance build up with MXP which results in the need to consume increasingly large doses in order to achieve the same level of effects. This should reset to baseline after 1 - 2 weeks. There may well be some addictive potential but this is still unknown.

Tolerance may be mitigated via preparing the citrate salt by mixing the chemical with citric acid or lemon juice, which will aid in absorption and increase effects.

Legal Issues:

MXP is currently a legal grey area world wide and freely available through the use of online research chemical vendors. This does not mean that you are guaranteed to be immune from legal prosecution should you be found in possession of this substance as it is likely to vary from country to country.

Conclusion:

This new dissociative is an extremely novel, capable and interesting compound. The potential negative effects are currently unknown so tread carefully and start with light dosages if you are so inclined.

This subjective effect breakdown was made in collaboration with PsychonautWiki user, PJosepherum.

Click here for a more comprehensive breakdown.

My previous post specifically announced a period of inactivity due to the claim that “we are slowly putting together our biggest project yet”. Now after 162 individual articles and 4 months of extremely time consuming work I am excited to announce the launch of an entirely new, fully functional and community driven website under the domain name of www.encyclopediapsychonautica.org. 

Since the very beginning, as this website has gradually progressed I have become increasingly aware that a tumblr blog is simply too self limiting of a host for a project of this size. Encyclopedia Psychonautica has therefore been created to serve as a wider reaching, legitimate version of disregardeverythingisay and the format of an open community driven wiki has been chosen so that the project can progress as quickly as possible and potentially become entirely self sufficient in its own momentum. 

The website itself is still very much in progress but ultimately exists for the purpose of attempting to establish psychonautics as a legitimate field of science and to reach an understanding of the hallucinogenic experience through a formal documentation and analysis of the consistent subjective effects found within it. We have done this through the act of producing an extremely organized phenomenological breakdown and description of the individual effects and experiences found within a wide variety of differing methodologies in an extremely high level of detail. This has been done from a purely rational perspective which defines its own formalized procedure in a manner which does not depend on analogy, metaphors or mysticism to convey its definitions. 

In a fashion that is similar to what I have been doing with DEIS for the past two years but with a more detailed, consistent and formalised writing style, the effects themselves are documented, organized and mapped out through the use of formal literary descriptions, terminologies and definitions which are organized into the separate articles below,

• Visual effects - Psychedelics
• Cognitive effects - Psychedelics
  
• Auditory effects - Psychedelics
• Physical effects - Psychedelics
  
• Subjective effects - Dissociatives
  
• Subjective effects - Deliriants
• Potential subjective effects index
  

Along side of these literary descriptions, relevant galleries of image examples are used where ever possible to further reproduce and convey specific categorized subjective effects. We have done this through the act of collecting and creating many image examples which have been catalogued and organized into the extensive hallucinogenic replication gallery which can be found here. This page serves the useful purpose of formally documenting experiences in a level of detail which descriptive language and written analysis could not possibly come close to by itself.

The information contained within the links above have then been used as standardized reference points for the ongoing project of documenting and describing the subjective effects of specific substances and hallucinogens within this extensive index here. This catalogue of specific substances currently documents 23 individual hallucinogens and includes a range of substances, plants and combinations which are organized into appropriate pharmacological and experiential categories. For this specific section of the website we have put careful consideration into providing accurate and comprehensive sets of information on not just the subjective effects but on the chemistry, pharmacology, studied therapeutic uses, lethal dosage, addiction potential, tolerance build up and legal issues with which the substance is associated with. This ensures that users can be fully informed in a way that intends to minimize danger, maximize safety and end the cultural taboos associated with personal hallucinogen usage by providing unbiased and scientifically accurate information.

In order to provide the information necessary to understand the basic physical processes involved within the consumption of these specific substances, we have included a comprehensive and relevant set of encyclopaedic pages which break down and describe the various methods of drug action, neurotransmitters, hormones, pharmacological classes and general neuroscience. These pages can be found within this index here and have been carefully written in a way that is both easy to understand for a novice whilst simultaneously remaining detailed and informative. 

In addition to breaking down the subjective effects and physical neurological processes behind various specific substances we have also provided sets of instructional information regarding a large host of recipes, chemical extraction methods and growing techniques for the preparation of different hallucinogens. This can be found within our hallucinogen preparation section here and currently includes multiple DMT and LSA extractions along side of changa and ayahuasca recipes which are written in clear, easy to understand step by step instructions. This section will be expanded over the upcoming weeks to include a wider array of preparation methods and serves the purpose of making hallucinogens significantly easier to obtain and more accessible to the masses.

As an experiment which eventually hopes to draw genuine statistical data from user submitted experiences we have included a section dedicated to cataloguing a database of user submitted trip reports which provides a detailed and formal analysis in the form of a tagging system below each individual experience. This serves the purpose of providing the community with a greater understanding of its own personal experiences and allows us to confirm the presence of individual subjective effects within specific substances. At the present moment this database of experiences includes 40 individual experiences and can be found here.

The biggest and most exciting difference between DEIS and EP stems entirely from the way in which anybody can now easily contribute their own personal sets of knowledge, ideas, expertise and experiences to this newly emerging field of formalized psychonautics. The prospect of community collaboration and drawing data from the psychedelic community as a whole has been without a doubt, the biggest source of personal motivation for setting up a project of this scale. There are many ways in which others can help and these include,

• Submitting trip reports.
• Writing up breakdowns and descriptions of currently undocumented specific substances.
• Submitting extractions, recipes, growing techniques and preparation methods.
• Submitting collected or original hallucinogenic replications in the form of images, video or even audio.
• Submitting currently undocumented subjective hallucinogenic effects.
• Writing up new articles.
• Expanding upon and editing old articles.
• Following the community to-do list which can be found here.
• Bitcoin donations (1t5frxXujGz1reHrzNaAq4X3vrNM4c2NL) - any and all donations are greatly appreciated and go directly towards the financial upkeep of server maintenance, producing content and furthering the cause.

If you want to contribute but are unfamiliar with standard wiki formatting or do not feel that you possess the literary capabilities to develop your ideas or information in a comprehensive and legitimate manner, we have provided submission alternatives aside from writing the article up yourself. These include submitting your ideas and content to our community discussion subreddit found here, posting to the inbuilt discussion sections found within every article, talking with us in our live IRC chat room found here or simply emailing us at encyclopediapsychonautica@gmail.com. We strongly encourage you to contribute and even the smallest of submissions are sincerely appreciated. If we as a currently disorganized community of people are ever going to make a difference in terms of finally allowing humanity to benefit from what the hallucinogenic experience has to offer then we need to start collectively organizing and collaborating on a level which until this point, has been completely unheard of.

In terms of the short and long term future of both DEIS and EP, I have a huge multitude of elaborate yet necessary plans and general content that will need to be completed in order to progress the field of formalized psychonautics deeper into scientific legitimacy. For example, the creation of an automated piece of software which can generate accurate and statistical descriptions of any hallucinogen through the use of a complex questionnaire system will eventually be integrated into the website and has already been created in the form a manually operated prototype. Along side of this, I have plans for entirely new sections based on meditation and lucid dreaming as well as over 10 individual prewritten articles that will need to be posted to DEIS over the upcoming weeks. I am feeling more motivated and dedicated to this cause than ever before and strongly feel that we are stumbling upon a discovery of genuine historical significance and overwhelmingly profound implications. 

Just to let you know, today is the 2nd year anniversary of DEIS. Thank you for reading and thank you for your support. I am extremely excited to work with all of you in the future and can say with confidence that this is only just the beginning of our projects potential.