Disregard Everything I Say

Dosage (oral)

Threshold : 0.5 - 1mg
Light : 1 - 1.5mg
Common : 1.5 - 2.5mg
Strong : 2.5 - 5mg
Heavy : 5+ mg

Duration (oral)

Total Duration : 8 - 20 hrs
Onset : 20 - 90 minutes
Initial effects : 1 - 2 hours
Peak : 8 - 12 hours
Coming down : 1 - 3 hours
After effects : 2 - 4 hours

Dosage (insufflated)

Threshold : 0.5mg
Light : 0.5 - 1mg
Common : 1 - 2mg
Strong : 2.5 - 3.5mg
Heavy : 3.5 - 4+mg

Duration (insufflated)

Total Duration : 5 - 8 hrs
Onset : 1 - 2 minutes
Initial effects : 10 - 20 minutes
Peak : 2 - 4 hours
Coming down : 1 - 2 hours
After effects : 2 - 4 hours

2,5-Dimethoxy-4-chloroamphetamine (DOC) is a psychedelic substituted alpha-methylated phenethylamine, a class of compounds commonly known as amphetamines. The phenethylamine equivalent of this substance (lacking the alpha-methyl group) is 2C-C.

This substance has no history of human usage prior to the 1991 publication of its synthesis and pharmacology in the book PiHKAL (Phenethylamines i Have Known And Loved) by Alexander Shulgin. In modern times it is used as a recreational drug and an entheogen, rarely sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors.It was first synthesized by Alexander Shulgin and described in his 1991 book.

In terms of its pharmacology, this substance acts as a selective 5-HT2A, 5-HT2B, and 5-HT2C receptor partial agonist. Its psychedelic effects are thought to be mediated via its actions on the 5-HT2A receptor.

DOC is a highly dose sensitive psychedelic that is often sold on blotting paper and known for its strong visuals and intense body load. Many reports also indicate that the effects of this chemical may be overly intense for those who are not already experienced with psychedelics.

The DOC experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe…

Physical effects:

The body high of DOC is manifested as somewhat intense in comparison to most classical psychedelics. The sensation itself can be described as a constantly present yet somewhat mild energetic pins and needles sensation that encompasses a person’s entire body. It is usually felt over every square inch of the skin but occasionally manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.

In terms of its effects on the physical energy levels of the tripper DOC is usually considered to be extremely stimulating at levels which do not become overwhelming, resulting in a shakiness and unsteadiness of the hands but encouraging trippers to move around, run, dance, climb and generally engage in physical activities. In comparison, other more commonly used psychedelics such as psilocin are generally sedating and relaxed.

In terms of the physical discomfort experienced on this substance, mild to extreme nausea is reported when consumed in moderate to high dosages and either passes once the tripper has vomited or gradually fades by itself as the peak sets in.

Along side of this, many users commonly report that when high doses are taken vasoconstriction can be particularly uncomfortable, often exacerbated by the long duration of the substance.

Bodily enhancements,

DOC presents a full and complete array of bodily enhancements which generally includes,

• Enhanced tactile sensations
• Increased bodily awareness
• Increased muscle control

Cognitive effects:

The head space of DOC is described by many as one of extreme mental stimulation and a powerful enhancement of a person’s current mental state. This further manifests itself as two different styles of head space that depend entirely on the setting. For example, when taken alone these effects manifest themselves as psychedelic introspection but can also present strong entactogenic effects when taken with others. These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA and 2C-B but still prove strong enough to provide long lasting therapeutic effects.

The total sum of these cognitive components regardless of the setting generally includes,

• Introspection
• Acceleration of thought
• Ego suppression, loss and death
• Time distortion
• Feelings of fascination, importance and awe
• Conceptual thinking
• Increased connectivity of thought
• Enhancement of current mindstate
• Removal of cultural filter
• Entactogenic effects (increased empathy and sociability)

Visual effects:

Enhancements,

DOC presents a full and complete array of possible visual enhancements which generally includes,

• Increased visual acuity
• Enhancement of colours
• Enhanced pattern recognition

Distortions,

As for visual distortions and alterations, effects experienced are detailed below,

• Visual drifting (Melting, Flowing, Breathing and morphing) - In comparison to other psychedelics this effect can be described as highly detailed, slow and smooth in motion, static in their appearance and unrealistic/ cartoon like in style.
• Tracers
• After images
• Texture repetition
• Colour shifting
• Scenery slicing

Geometry,

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT, Ayahuasca than that of LSD, 2C-B or 2C-I. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, sharp in their edges and equally rounded and angular in their corners. They give off a contradictory natural and synthetic feel to them that at higher dosages are significantly more likely to result in states of Level 7B visual geometry over Level 7A.

Hallucinatory states,

DOC and other substituted amphetamines produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the the phenethylamine family. These effects include,

• Transformations
• Imagery - in comparison to other psychedelics such as LSD, DOC is extremely high in imagery embedded within visual geometry.
• Hallucinations - this particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.

Auditory effects:

The auditory effects of DOC are common in their occurrence and exhibit a full range of effects which commonly includes,

• enhancements
• distortions
• hallucinations

Health effects, addiction potential and tolerance:

The toxicity and long term health effects of recreational DOC use does not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because DOC is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried DOC within the psychedelic community suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly but nothing can be completely guaranteed.

DOC is not physically addictive, and many users experience a frequency self-regulating quality to the drug. Tolerance for DOC seems to be very mild and does not build up without repeated use over a short period of time.

Legal Issues:

• Denmark: DOC is a Schedule I drug.
• Finland: Possession, production and sale is illegal.
• Israel: Possession, production and sale is illegal.
• New Zealand: DOC is a Class C drug.
• Poland: DOC is not controlled in Poland and no analog law covers it.
• Germany: DOC is listed in Anlage I in Germany, making it illegal to buy, sell, or possess without a license
• Canada: DOC is Schedule III in Canada, making it illegal to sell, buy, or possess without a license.
• UK: DOC is a Class A drug.
• USA: DOC is technically not scheduled in the United States, but could be considered an analogue of DOM or DOB and therefore a Schedule I drug.

Conclusion:

In conclusion, I was surprised at the extent to which DOC manifested positive cognitive alterations, hallucinatory states and a style of visual effects which is similar in appearance to mushrooms or 2C-E. The substances ability to maintain a level of stimulation which is not overly forceful makes it extremely useful for both psychonautic exploration and recreational events such as music festivals and raves.

This substances subjective effect breakdown was contributed by Encyclopedia Psychonautica admin, Cocoanatta.

Dosage (sublingual)

Threshold : 25-150µg
Light : 150-400µg
Common : 450-600µg
Strong : 700-1200µg

Duration

Total Duration : 4 - 6 hrs
Onset : 15 - 120 mins
Coming Up : 30 - 120 mins
Peak : 2 - 3 hrs
Coming down : 1 - 2 hrs
After effects : 5 - 24 hrs

25C-NBOMe  or 2C-C-NBOMe is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-C.

It has nearly no history of human use prior to 2010 when it first became popular due its ease of purchase from online research chemical vendors.

25C-NBOMe  was discovered in 2003 by Ralf Heim at the Free University of Berlin, it differs from 2C-C structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group as shown in the image above. This change in structure results in roughly a sixteen fold increase in potency when compared to 2C-C, allowing even the most extreme of dosages to fit in liquid form onto tabs and blotter paper which people often mistake for LSD.

There are, however, methods of differentiating between LSD and adulterants like 25-C-NBOMe  with and without test kits.

For example, one of the key differences between 25C-NBOMe  and LSD is that this substance is only active when taken through a sublingual or insufflated route. This means that in order to get the full effects, 25C-NBOMe  blotter paper must be lightly chewed on within the mouth for 10 - 20 minutes and never immediately swallowed.

Insufflation however is not recommended due to the amount of people who have suffered through dangerous and often fatal overdoses thanks to this route of administration.

The 25C-NBOMe experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe…

Physical effects:

Assuming the substance has been taken sublingually, the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very obvious feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed. This is the key difference when it comes to determining whether your blotter paper contains LSD or one of the NBOMe series.

The body high itself can be described as a generally mild, all-encompassing, soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of euphoria that become longer and more drawn out proportional to the dosage consumed. In terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness.

In terms of its effects on the physical energy levels of the tripper, 25C-NBOMe is usually considered to be energetic and stimulating, but it can be considered less stimulating when compared to 25I-NBOMe. For most people, this substance induces a unique type of physical stimulation which can be described as feeling extremely energetic but in a way which does not force the tripper to move unless they genuinely choose to do so. For others however, the stimulation can be quite uncontrollable, occasionally resulting in bodily shakes and a grinding of the teeth comparable to that of MDMA and traditional stimulants such as amphetamine, but this is manifested much less consistently when compared to 25I-NBOMe.

Negative physical side effects,

It is worth noting that an undetermined percentage of people who experiment with this drug will experience negative physical side effects, such as a temporary difficulty in urinating and vasoconstriction. This is defined as the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels and is triggered through the way in which 25C-NBOMe’s target receptor (5-HT2A) modulates both vasoconstriction and vasodilation among its many other functions.

Physically speaking, this can become very uncomfortable but can be considered as safe at low to moderate dosages. The sensation itself can be described as feelings of tightness and mild to distinct stinging sensations within the arms, legs and neck.

As the tripper begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, but passes once this has either happened or the trip begins to fully set in. In comparison to other psychedelics such as psilocin, LSD, 2C-E and 2C-I, this could actually be very considered very mild in its intensity.

Cognitive effects:

The head space of 25C-NBOMe is described by many as remarkably light and underwhelming in comparison to the classical psychedelics. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout low to moderate dosages. At high dosages however, mild to overwhelming cognitive alterations become present, this dosage seems to be lower in proportion to physical effects when compared to 25I-NBOMe.

The most prominent of these cognitive effects generally include,

• Introspection
• Acceleration of thought
• Ego suppression, loss and death
• Time distortion
• Mindfulness
• Conceptual thinking
• Increased connectivity of thought
• Enhancement of current mindstate
• Suppression of cultural filter
• Entactogenic effects (increased empathy and sociability) - These effects range from mild to powerful, but are inconsistently manifested, although usually become prominent in the presence of others. In comparison, feelings of increased sociability, love and empathy do not seem to be quite as strong or profound as those found within other entactogens (such as MDMA or 2C-B).

Visual effects:

Enhancements,

25C-NBOMe presents a full and complete array of possible visual enhancements which generally includes,

• Increased visual acuity
• Enhancement of colours
• Enhanced pattern recognition

Distortions,

The visual distortions and alterations which are experienced are detailed below,

• Visual drifting (Melting, Flowing, Breathing and morphing) - In comparison to other psychedelics this effect can be described as highly detailed, slow and smooth in motion, static in their appearance and unrealistic/ cartoon like in style.
• Tracers
• After images
• Texture repetition - in comparison to other psychedelics such as LSD or psilocin, this particular visual alteration is significantly more basic and less intricate in style but still distinctively present and seems more intricate in comparison to 25I-NBOMe.

Geometry,

The visual geometry that is present throughout this trip is often described as very similar in appearance to that of LSD. They can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colourful in scheme, glossy in colour, sharp around the edges and mostly rounded across their corners. In comparison to other more commonly used psychedelics they can be described as significantly more intricate than the visual geometry found within 2C-I and most of the 2C-x family in general as well as completely on par with LSD, Psilocin and DMT at appropriately high dosages, which seem lower in proportion to the accompanying physical effects when compared to that of 25I-NBOMe.

In terms of their behaviour, 25C-NBOMe’s geometry leads onto Level 7A visual geometry with Level 7B remaining so far unconfirmed within this substance. They also seem to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelops the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it.

Hallucinatory states,

25C-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. However, level 4 hallucinatory breakthroughs are reported but very uncommon and inconsistent in comparison to other more commonly used psychedelics such as psilocin, 2C-E and DMT. This can be considered as on par with and iedntical in behaviour to that of LSD and 25I-NBOMe.

These effects include,

• Transformations
• Imagery
• Hallucinations - this particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.

Auditory effects:

The auditory effects of 25C-NBOMe are common in their occurrence and exhibit a full range of effects which commonly includes,

• enhancements
• distortions
• hallucinations

Health effects, addiction potential and tolerance:

25C-NBOMe is a very new substance, and little is known about its pharmacological or behavioural risks. The LD50 is not known. Some deaths have been attributed to 25C-NBOMe overdose caused by improper handling and uneducated use of this substance. Its recent widespread use suggests that death is primarily caused from overdoses and not from ordinary doses, particularly from insufflation.

The fact that 25C-NBOMe is active in the microgram range is likely a contributing factor since this makes measuring doses significantly more difficult. 

It’s worth noting that although many 5-HT2A agonists have documented safety, none of these have been full agonists so their safety data can not be applied to 25C-NBOMe.

In terms of its addictive potential, 25C-NBOMe has not been studied formally but due to its immediate tolerance build up which lasts up to 2 - 3 weeks after the experience, it is essentially impossible to use this substance compulsively.

Legal Issues:

• UK: The 25x-NBOMe series is under a temporary class drug order, lasting one year from 10th June 2013.
• USA: 25C-NBOMe is technically unscheduled under federal law, but could be considered an analogue of 2C-C and therefore a Schedule I drug.

Conclusion:

The subjective effects breakdown contained within this article was written and contributed by the encyclopedia psychonautica admin known as cocoanatta. This demonstrates that people beyond myself can produce formal and detailed hallucinogenic subjective effect breakdowns by simply following the standardized system defined within our potential subjective effects index. I encourage anybody else who wants to contribute to do so and I can safely say that community collaboration is going to play a much larger role across this website in the future.

As for the substance itself, 25C-NBOMe  and the NBOMe series as a whole are an extremely interesting set of psychedelics but do not quite compare in terms of hallucinatory and cognitive depth if you have access to classical psychedelics such as genuine LSD, DMT and Psilocin.

Please let me know if you agree or disagree with any particular points contained within this article by using the comment system below.