Disregard Everything I Say

Dosage:

Threshold : 100 µg
Light : 100 - 300 µg
Common : 350 - 700 µg
Strong : 700 - 1500 µg

Duration:

Total duration : 8 - 10 hrs
Onset / Initial effects : 15 - 60 mins
Coming up : 60 - 120 mins
Peak : 3 - 4 hrs
Coming down : 1 - 2 hrs
After effects : 5 - 24 hrs

25B-NBOMe can be fatal at heavy doses.^[1] It is strongly discouraged to take large amounts of this substance or to snort it.

25B-NBOMe or 2C-B-NBOMe is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-B.

It has nearly no history of human use prior to 2010 when it first became popular due its ease of purchase from online research chemical vendors.

25B-NBOMe has efficacy at the 5-HT_2A receptor where it acts as a potent partial agonist. It was discovered in 2003 by Ralf Heim at the Free University of Berlin, it differs from 2C-B structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group as shown in the image above. This change in structure results in roughly a sixteen fold increase in potency when compared to 2C-B, allowing even the most extreme of dosages to fit in liquid form onto tabs and blotter paper (which people often mistake for LSD).

There are, however, methods of differentiating between LSD and adulterants like 25B-NBOMe with and without test kits.

For example, one of the key differences between 25B-NBOMe and LSD is that this substance is only active when taken through a sublingual or insufflated route. This means that in order to get the full effects, 25B-NBOMe blotter paper must be lightly chewed on within the mouth for 10 - 20 minutes and never immediately swallowed.

Insufflation, however, is not recommended due to the amount of people who have suffered through dangerous and often fatal overdoses due to this route of administration.

The 25B-NBOMe experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical effects:

The physical effects of 25B-NBOMe can be broken down into six components all of which progressively intensify proportional to dosage. These are described below and generally include:

• Sublingual numbing - assuming the substance has been taken sublingually, the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very obvious feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed. This is the key difference when it comes to determining whether your blotter paper contains LSD or one of the NBOMe series.
• Spontaneous tactile sensations - the body high itself can be described as a generally mild, all-encompassing, soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of euphoria that become longer and more drawn out proportional to the dosage consumed.
• Decreased bodily weight - in terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness.
• Stimulation - in terms of its effects on the physical energy levels of the tripper, 25B-NBOMe is usually considered to be energetic and stimulating, but it can be considered less stimulating when compared to 25I-NBOMe. For most people, this substance induces a unique type of physical stimulation which can be described as feeling extremely energetic but in a way which does not force the tripper to move unless they genuinely choose to do so. For others however, the stimulation can be quite uncontrollable, occasionally resulting in bodily shakes and a grinding of the teeth comparable to that of MDMA and traditional stimulants such as amphetamine, but this is manifested much less consistently when compared to 25I-NBOMe
• Vasoconstriction - it is worth noting that an undetermined percentage of people who experiment with this drug will experience negative physical side effects, such as a temporary difficulty in urinating and vasoconstriction. This is defined as the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels and is triggered through the way in which 25B-NBOMe’s target receptor (5-HT2A) modulates both vasoconstriction and vasodilation among its many other functions.
• Nausea - as the tripper begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, but passes once this has either happened or the trip begins to fully set in. In comparison to other psychedelics such as psilocin, LSD, 2C-E and 2C-I, this could actually be very considered very mild in its intensity.

Cognitive effects:

The head space of 25B-NBOMe is described by many as remarkably light and underwhelming in comparison to the classical psychedelics. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout low to moderate dosages. At high dosages however, mild to overwhelming cognitive alterations become present.

The most prominent of these cognitive effects generally include:

• Introspection - this component is consistently manifested only in the context of a non-social setting in which the user is alone.
• Increased empathy, love and sociability - the entactogenic effects range from mild to powerful, but are inconsistently manifested. entactogenic effects for people who try this substance usually become prominent in the presence of others. These feelings of increased sociability, love and empathy do not seem to be quite as strong or profound as those found within other entactogens (such as MDMA, 2C-B and AMT)
• Acceleration of thought
• Time distortion
• Feelings of fascination, importance and awe
• Conceptual thinking
• Connectivity of thought
• Enhancement of current mind state
• Removal of cultural filter
• Ego suppression, loss and death

Visual effects:

Enhancements

25B-NBOMe presents a full and complete array of possible visual enhancements which generally includes:

• Increased visual acuity
• Enhancement of colour
• Enhanced pattern recognition

Distortions

The visual distortions and alterations which are experienced are detailed below:

• Drifting (Melting, Flowing, Breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in their appearance and unrealistic/cartoon-like in style.
• Tracers
• After images
• Texture repetition
• Colour shifting
• Scenery slicing

Geometry

The visual geometry that is present throughout this trip is often described as similar in appearance to that of LSD. They can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colourful in scheme, glossy in colour, sharp around the edges and mostly rounded across their corners. In comparison to other more commonly used psychedelics they can be described as significantly more intricate than the visual geometry found within 2C-I and most of the 2C-x family in general as well as completely on par with LSD, Psilocin and DMT at appropriately high dosages.

In terms of their behaviour, 25B-NBOMe’s geometry leads onto Level 7A visual geometry with Level 7B remaining so far unconfirmed within this substance. They also seem to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelops the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it.

Hallucinatory states

25B-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. However, level 4 hallucinatory breakthroughs are reported but very uncommon and inconsistent in comparison to other more commonly used psychedelics such as psilocin, 2C-E and DMT.

These effects include:

• External hallucinations
• Internal hallucinations - this particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.

Auditory effects:

The auditory effects of 25B-NBOMe are common in their occurrence and exhibit a full range of effects which commonly includes:

• Enhancements
• Distortions
• Hallucinations

Health effects, addiction potential and tolerance:

25B-NBOMe is a very new substance and little is known about its pharmacological or behavioural risks. The LD50 is not known. Some deaths have been attributed to 25B-NBOMe overdose caused by improper handling and uneducated use of this substance. Its recent widespread use suggests that death is primarily caused from overdoses and not from ordinary doses, particularly from insufflation.

The fact that 25B-NBOMe is active in the microgram range is likely a contributing factor since this makes measuring doses significantly more difficult. 

In terms of its addictive potential, 25B-NBOMe has not been studied formally but due to its immediate tolerance build up which lasts up to 2 - 3 weeks after the experience, it is essentially impossible to use this substance compulsively.

Legal issues:

• UK: 25B-NBOMe is under a temporary class drug order, lasting one year from 10th June 2013.
• Sweden: 25b-NBOMe is classed as schedule I.
• USA: On Nov 15, 2013, the DEA added 25B-NBOMe to Schedule I using their emergency scheduling powers, making it “temporarily” in Schedule I for 2 years.

Conclusion:

As for the substance itself, 25B-NBOMe  and the NBOMe series as a whole are an extremely interesting set of psychedelics but do not quite compare in terms of hallucinatory and cognitive depth if you have access to classical psychedelics such as genuine LSD, DMT and psilocin.

Please let me know if you agree or disagree with any particular points contained within this article by using the comment system below.

Click here for a more comprehensive article.

Dosage (oral)
Threshold : 2-5mg
Light : 5-15mg
Common : 10-25mg
Strong : 20-30mg
Heavy : 30+mg

Duration (oral)
Total duration : 5 - 8 hours
Onset : 20 - 90 minutes
Come up : 20 - 30 minutes
Peak : 3 - 7 hours
Come down : 1 - 2 hours
After effects : 2 - 4 hours

2C-I or 2,5-dimethoxy-4-iodophenethylamine is a psychedelic phenethylamine of the 2C-x family. It was first synthesized by Alexander Shulgin. It was described in Shulgin’s 1991 book PiHKAL: A Chemical Love Story. The drug is used recreationally for its psychedelic and entactogenic effects and is sometimes confused for the analog 25I-NBOMe. 2C-I is commonly sold in its hydrochloride salt form, which is a fluffy, sparkling, white powder, which can sometimes be pressed into tablet form. 2C-I has been explored as a potential stimulant nootropic in doses between 1-8mg.

In terms of its chemistry, 2C-I is a substituted phenethylamine with methoxy groups attached carbons R2 and R5 as well as an iodine molecule attached to carbon R4. It is thought to have efficacy at the 5-HT2A receptor as a partial agonist.

The 2C-I experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical effects:

The physical effects of 2C-I can be broken down into five components all of which progressively intensify proportional to dosage. These are described below and generally include:

• Spontaneous tactile sensations - The body high of 2C-I is manifested as one of the most proportionally intense in comparison to almost all of the classical psychedelics. The sensation itself can be described as an intense and slightly uncomfortable energetic pins and needles sensation that constantly encompasses a person’s entire body. It is usually felt over every square inch of the skin but occasionally manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves. Alongside of this, many users commonly report that the body high can be particularly uncomfortable and sometimes accompanied by dysphoric aches and urges to shift the position of one’s body and prolonged tensing of unusual combinations of muscle groups.
• Euphoria - Feelings of frequent but unpredictable rushes of warm physical euphoria are extremely common and very pleasurable. These move from the top of the head downwards before envoloping ones whole body.
• Stimulation - In terms of its effects on the physical energy levels of the tripper, 2C-I is usually considered to be very energetic and stimulating in a fashion that is quite comparable to that of MDMA although encouraged instead of forced.
• Increased bodily control
• Enhancement of touch
• Nausea - Mild to extreme nausea is consistently reported when consumed in moderate to high dosages and either passes once the tripper has vomited or gradually fades by itself as the peak sets in.
• Loss of temperature regulation
• Head aches - Some users report mild but uncomfortable head pressures which can occasionally intensify during the offset of the experience.

Cognitive effects:

The head space of 2C-I is described by many as one which is relatively normal in its thought processes even at moderate to high dosages. It is often said to lack insight when compared to that of 2C-E, 2C-B and LSD.
The total sum of these cognitive components regardless of the setting generally includes:

• Increased empathy, love and sociability - This component is consistently manifested only in the context of social settings in which one is within the company of others. These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA and 2C-B but still prove strong enough to provide long lasting therapeutic effects.
• Time distortion
• Feelings of fascination, importance and awe
• Sexual arousal
• Enhancement of current mind state
• Ego suppression, loss and death
• States of unity and interconnectedness

Visual effects:

Enhancements

2C-I presents a full and complete array of possible visual enhancements which generally includes:

• Increased visual acuity
• Enhancement of colour
• Enhanced pattern recognition

Distortions

2C-I presents a full and complete array of possible visual distortions which generally includes:

• Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as simplistic and bland in detail, slow and smooth but sometimes jittery in motion, static in appearance and unrealistic/cartoon-like in style.
• Tracers
• Symmetrical texture repetition - In comparison to other psychedelics such as LSD and 2C-E this particular effect is bland and simplistic.
• Colour shifting
• Scenery slicing

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of LSD or 2C-B than that of 2C-E, psilocin, or ayahuasca although it is much more bland and less detailed. They can be comprehensively described as unstructured in their organization, algorithmic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, both soft and sharp in their edges as well as equally rounded and angular in their corners. They seem high in algorithmic visuals such as fractals and at higher dosages are significantly more likely to result in states of Level 7A visual geometry over Level 7B.

Hallucinatory states

Like LSD, while 2C-I is capable of producing a full range of low and high level hallucinatory states, this is extremely rare and inconsistent at higher levels but common at lower and generally includes the following effects:

• External hallucinations - The experience of effects such as open eye transformations are common within 2C-I but not consistent.
• Internal hallucinations - Although 2C-I is technically capable producing of hallucinatory states in a fashion that is on par with psilocin or DMT in its vividness and intensity, in comparison, these effects are extremely rare and inconsistent. Whilst traditional psychedelics such as LSA, Ayahuasca and Mescaline will induce internal hallucinations near consistently at level 5 geometry and above, 2C-I hallucinations will not extend beyond imagery and higher dosages will for most will simply go straight into Level 7A visual geometry. This lack of consistently induced hallucinatory breakthroughs means that for most, 2C-I is simply not as deep of an experience as certain other psychedelics.

Auditory effects:

The auditory effects of 2C-I are common in their occurrence and exhibit a full range of effects which commonly include:

• Enhancements
• Distortions
• Hallucinations

Health effects, addiction potential and tolerance:

The toxicity and long term health effects of recreational 2C-I use does not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 2C-I is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried 2C-I within the psychedelic community suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).

There is a short period of tolerance after 2C-I use. Using 2C-I two days in a row is likely to lead to a diminished experience the second day. However, this effect is nearly non-existent when spaced 5-7 days apart.

Legal issues:

• European Union: In December 2003, the European Council issued a binding order compelling all EU member states to ban 2C-I within three months.
• Denmark: It is a controlled substance.
• Germany: It is a controlled substance.
• Greece: It is a controlled substance.
• Ireland: The drug is a controlled substance.
• Italy: It is a controlled substance.
• Netherlands: It is a controlled substance.
• Poland: It is a controlled substance.
• Sweden: Sveriges riksdag added 2C-I to schedule I (“substances, plant materials and fungi which normally do not have medical use”) as narcotics in Sweden as of March 16, 2004. 
• United Kingdom: It is controlled as a Class A substance.
• USA: As of July 9, 2012, in the United States, 2C-I is a Schedule I substance under the Synthetic Drug Abuse Prevention Act of 2012, making possession, distribution and manufacture illegal.

Conclusion:

2C-I is a worthwhile experience but is not as deep as other drugs of the same family. It is a substance which works better for some than others. For example, while many find it to be extremely uncomfortable others find it perfect for recreational use in public and social environments. 

This subjective effect breakdown was made in collaboration with PsychonautWiki admin, Oscarette. 

Click here for a more comprehensive breakdown.

Dosage (sublingual)

Threshold : 25-150µg
Light : 150-400µg
Common : 450-600µg
Strong : 700-1200µg

Duration

Total Duration : 4 - 6 hrs
Onset : 15 - 120 mins
Coming Up : 30 - 120 mins
Peak : 2 - 3 hrs
Coming down : 1 - 2 hrs
After effects : 5 - 24 hrs

25C-NBOMe can be fatal at heavy doses (as low as 4mg).^[1] It is strongly discouraged to take large amounts of this substance or to snort it.

25C-NBOMe or 2C-C-NBOMe is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-C.

It has nearly no history of human use prior to 2010 when it first became popular due its ease of purchase from online research chemical vendors.

25C-NBOMe was discovered in 2003 by Ralf Heim at the Free University of Berlin, it differs from 2C-C structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group as shown in the image above. This change in structure results in roughly a sixteen fold increase in potency when compared to 2C-C, allowing even the most extreme of dosages to fit in liquid form onto tabs and blotter paper (which people often mistake for LSD).

There are, however, methods of differentiating between LSD and adulterants like 25-C-NBOMe with and without test kits.

For example, one of the key differences between 25C-NBOMe and LSD is that this substance is only active when taken through a sublingual or insufflated route. This means that in order to get the full effects, 25C-NBOMe blotter paper must be lightly chewed on within the mouth for 10 - 20 minutes and never immediately swallowed.

Insufflation, however, is not recommended due to the amount of people who have suffered through dangerous and often fatal overdoses due to this route of administration.

The 25C-NBOMe experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical effects:

The physical effects of 25C-NBOMe can be broken down into six components all of which progressively intensify proportional to dosage. These are described below and generally include:

• Sublingual numbing - assuming the substance has been taken sublingually, the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very obvious feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed. This is the key difference when it comes to determining whether your blotter paper contains LSD or one of the NBOMe series.
• Spontaneous tactile sensations - the body high itself can be described as a generally mild, all-encompassing, soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of euphoria that become longer and more drawn out proportional to the dosage consumed.
• Decreased bodily weight - in terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness.
• Stimulation - in terms of its effects on the physical energy levels of the tripper, 25C-NBOMe is usually considered to be energetic and stimulating, but it can be considered less stimulating when compared to 25I-NBOMe. For most people, this substance induces a unique type of physical stimulation which can be described as feeling extremely energetic but in a way which does not force the tripper to move unless they genuinely choose to do so. For others however, the stimulation can be quite uncontrollable, occasionally resulting in bodily shakes and a grinding of the teeth comparable to that of MDMA and traditional stimulants such as amphetamine, but this is manifested much less consistently when compared to 25I-NBOMe
• Vasoconstriction - it is worth noting that an undetermined percentage of people who experiment with this drug will experience negative physical side effects, such as a temporary difficulty in urinating and vasoconstriction. This is defined as the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels and is triggered through the way in which 25I-NBOMe’s target receptor (5-HT2A) modulates both vasoconstriction and vasodilation among its many other functions.
• Nausea - as the tripper begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, but passes once this has either happened or the trip begins to fully set in. In comparison to other psychedelics such as psilocin, LSD, 2C-E and 2C-I, this could actually be very considered very mild in its intensity.

Cognitive effects:

The head space of 25C-NBOMe is described by many as remarkably light and underwhelming in comparison to the classical psychedelics. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout low to moderate dosages. At high dosages, however, mild to overwhelming cognitive alterations become present; this dosage seems to be lower in proportion to physical effects when compared to 25I-NBOMe.
The most prominent of these cognitive effects generally include:

• Introspection - this component is consistently manifested only in the context of a non-social setting in which the user is alone.
• Increased empathy, love and sociability - the entactogenic effects range from mild to powerful, but are inconsistently manifested. Entactogenic effects for people who try this substance usually become prominent in the presence of others. These feelings of increased sociability, love and empathy do not seem to be quite as strong or profound as those found within other entactogens (such as MDMA, 2C-B and AMT)
• Acceleration of thought
• Time distortion
• Feelings of fascination, importance and awe
• Conceptual thinking
• Connectivity of thought
• Enhancement of current mind state
• Removal of cultural filter
• Ego suppression, loss and death

Visual effects:

Enhancements

25C-NBOMe presents a full and complete array of possible visual enhancements which generally include:

• Increased visual acuity
• Enhancement of colours
• Enhanced pattern recognition

Distortions

The visual distortions and alterations which are experienced are detailed below:

• Visual drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in their appearance and unrealistic/cartoon like in style.
• Tracers
• After images
• Texture repetition - In comparison to other psychedelics such as LSD or psilocin, this particular visual alteration is significantly more basic and less intricate in style but still distinctively present and seems more intricate in comparison to 25I-NBOMe.

Geometry

The visual geometry that is present throughout this trip is often described as very similar in appearance to that of LSD. They can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colourful in scheme, glossy in colour, sharp around the edges and mostly rounded across their corners. In comparison to other more commonly used psychedelics, they can be described as significantly more intricate than the visual geometry found within 2C-I and most of the 2C-x family in general as well as completely on par with LSD, psilocin and DMT at appropriately high dosages (which seem lower in proportion to the accompanying physical effects when compared to that of 25I-NBOMe).

In terms of their behaviour, 25C-NBOMe’s geometry leads onto Level 7A visual geometry with Level 7B remaining so far unconfirmed within this substance. They also seem to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelops the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it.

Hallucinatory states

25C-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. However, level 4 hallucinatory breakthroughs are reported but very uncommon and inconsistent in comparison to other more commonly used psychedelics such as psilocin, 2C-E and DMT. This can be considered as on par with and identical in behaviour to that of LSD and 25I-NBOMe.
These effects include:

• External hallucinations
• Internal hallucinations - this particular effect commonly contains hallucinations within scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.

Auditory effects:

The auditory effects of 25C-NBOMe are common in their occurrence and exhibit a full range of effects which commonly includes:

• Enhancements
• Distortions
• Hallucinations

Health effects, addiction potential and tolerance:

25C-NBOMe is a very new substance and little is known about its pharmacological or behavioural risks. The LD50 is not known. Some deaths have been attributed to 25C-NBOMe overdose caused by improper handling and uneducated use of this substance. Its recent widespread use suggests that death is primarily caused from overdoses and not from ordinary doses, particularly from insufflation.

The fact that 25C-NBOMe is active in the microgram range is likely a contributing factor since this makes measuring doses significantly more difficult. 

It’s worth noting that although many 5-HT2A agonists have documented safety, none of these have been full agonists so their safety data cannot be applied to 25C-NBOMe.

In terms of its addictive potential, 25C-NBOMe has not been studied formally but due to its immediate tolerance build up which lasts up to 2 - 3 weeks after the experience, it is essentially impossible to use this substance compulsively.

Legal Issues:

• UK: The 25x-NBOMe series is under a temporary class drug order, lasting one year from 10th June 2013.
• USA: On Nov 15, 2013, the DEA added 25C-NBOMe to Schedule I using their emergency scheduling powers, making it “temporarily” in Schedule I for 2 years

Conclusion:

The subjective effects breakdown contained within this article was written and contributed by the PsychonautWiki admin known as cocoanatta.

As for the substance itself, 25C-NBOMe  and the NBOMe series as a whole are an extremely interesting set of psychedelics but do not quite compare in terms of hallucinatory and cognitive depth if you have access to classical psychedelics such as genuine LSD, DMT and psilocin.

Please let me know if you agree or disagree with any particular points contained within this article by using the comment system below.

Click here for a more comprehensive article.

Duration,
Total : 6 - 10 hrs
Onset : 15 - 120 mins
Plateau : 2 - 4 hrs
Coming Down : 1 - 4 hrs

Dosage,
Threshold : 50 - 250 ug (micrograms)
Light : 200 - 600 ug
Common : 500 - 800 ug
Strong : 700 - 1500 ug

25I-NBOMe can be fatal at heavy doses.^[1] It is strongly discouraged to take large amounts of this substance or to snort it.

25I-NBOMe or 2C-I-NBOMe is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-I.

It has nearly no history of human use prior to 2010 when it first became popular due its ease of purchase from online research chemical vendors.

25I-NBOMe was discovered in 2003 by Ralf Heim at the Free University of Berlin. It differs from 2C-I structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group as shown in the image above. This change in structure results in a sixteen fold increase in potency when compared to 2C-I, allowing even the most extreme of dosages to fit in liquid form onto tabs and blotter paper (which people often mistake for LSD).

There are, however, methods of differentiating between LSD and adulterants like 25I-NBOMe with and without test kits.

For example, one of the key differences between 25I-NBOMe and LSD is that this substance is only active when taken through a sublingual or insufflated route. This means that in order to get the full effects, 25I-NBOMe blotter paper must be lightly chewed on within the mouth for 10 - 20 minutes and never immediately swallowed.

Insufflation, however, is not recommended due to the amount of people who have suffered through dangerous and often fatal overdoses due to this route of administration.

25I-NBOMe is pharmacologically unique when compared to other psychedelics through the way in which it is one of the only full agonists for the human 5ht2a receptor in existence. In comparison, classical psychedelics such as LSD, DMT and psilocin can only be considered partial agonists.

This difference in receptor affinity results in an unusual and qualitatively different trip which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical effects:

The physical effects of 25I-NBOMe can be broken down into six components all of which progressively intensify proportional to dosage. These are described below and generally include:

• Sublingual numbing - assuming the substance has been taken sublingually, the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very obvious feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed. This is the key difference when it comes to determining whether your blotter paper contains LSD or one of the NBOMe series.
• Spontaneous tactile sensations - the body high itself can be described as a generally mild, all-encompassing, soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of euphoria that become longer and more drawn out proportional to the dosage consumed.
• Decreased bodily weight - in terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness.
• Stimulation - in terms of its effects on the physical energy levels of the tripper 25I-NBOMe is usually considered to be very energetic and stimulating. For most people, this substance induces a unique type of physical stimulation which can be described as feeling extremely energetic but in a way which does not force the tripper to move unless they genuinely choose to do so. For others however, the stimulation can be quite uncontrollable, occasionally resulting in bodily shakes and a grinding of the teeth comparable to that of MDMA and traditional stimulants such as amphetamine.
• Vasoconstriction - this is defined as the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels and is triggered through the way in which 25I-NBOMe’s target receptor (5-HT2A) modulates both vasoconstriction and vasodilation among its many other functions. It can be described as feelings of tightness within one’s arms and legs.
• Nausea - as the tripper begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, but passes once this has either happened or the trip begins to fully set in. In comparison to other psychedelics such as psilocin, LSD, 2C-E and 2C-I, this could actually be very considered very mild in its intensity.

Cognitive effects:

The head space of 25I-NBOMe is described by many as remarkably light and underwhelming in comparison to the classical psychedelics. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout low to moderate dosages. At high dosages however, mild to overwhelming cognitive alterations become present.

The most prominent of these cognitive effects generally include:

• Introspection - this component is consistently manifested only in the context of a non-social setting in which the user is alone.
• Acceleration of thought
• Ego suppression, loss and death
• Time distortion
• Feelings of fascination, importance and awe
• Conceptual thinking
• Connectivity of thought
• Enhancement of current mind state
• Removal of cultural filter
• Increased empathy, love and sociability - the entactogenic effects range from mild to powerful, but are inconsistently manifested. Entactogenic effects for people who try this substance usually become prominent in the presence of others. These feelings of increased sociability, love and empathy do not seem to be quite as strong or profound as those found within other entactogens (such as MDMA, 2C-B and AMT)

Visual effects:

Enhancements

25I-NBOMe presents a full and complete array of possible visual enhancements which generally include:

• Increased visual acuity
• Enhancement of colours
• Enhanced pattern recognition

Distortions

The visual distortions and alterations which are experienced are detailed below:

• Visual drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in their appearance and unrealistic/cartoon like in style.
• Tracers
• After images
• Texture repetition - In comparison to other psychedelics such as LSD or psilocin, this particular visual alteration is significantly more basic and less intricate in style but still distinctively present.

Geometry

The visual geometry that is present throughout this trip is often described as similar in appearance to that of LSD. They can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colourful in scheme, glossy in colour, sharp around the edges and mostly rounded across their corners. In comparison to other more commonly used psychedelics, they can be described as significantly more intricate than the visual geometry found within 2C-I and most of the 2C-x family and are completely on par with LSD, Psilocin and DMT at appropriately high dosages.

In terms of their behaviour, 25I-NBOMe’s geometry leads onto Level 7A visual geometry with Level 7B remaining so far unconfirmed within this substance. They also seem to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelops the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it.

Hallucinatory states

25I-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. However, level 4 hallucinatory breakthroughs are reported but very uncommon and inconsistent in comparison to other more commonly used psychedelics such as psilocin, 2C-E and DMT.

These effects include:

• External hallucinations
• Internal hallucinations - this particular effect commonly contains hallucinations within scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.

Auditory effects:

The auditory effects of 25I-NBOMe are common in their occurrence and exhibit a full range of effects which commonly include:

• Enhancements
• Distortions
• Hallucinations

Health effects, addiction potential and tolerance:

25I-NBOMe is a very new substance and little is known about its pharmacological or behavioural risks. The LD50 is not known. Some deaths have been attributed to 25I-NBOMe overdoses caused by improper handling and uneducated use of this substance. Its recent widespread use suggests that death is primarily caused from overdoses and not from ordinary doses, particularly from insufflation.

The fact that 25I-NBOMe is active in the microgram range is likely a contributing factor since this makes measuring doses significantly more difficult. 

It’s worth noting that although many 5-HT2A agonists have documented safety, none of these have been full agonists so their safety data cannot be applied to 25I-NBOMe.

In terms of its addictive potential, 25I-NBOMe has not been studied formally but due to its immediate tolerance build up which lasts up to 2 - 3 weeks after the experience, it is essentially impossible to use this substance compulsively.

Legal issues:

• 25I-NBOMe is unscheduled under United States federal law. However, it could possibly be considered an analog of 2C-I (a Schedule I controlled substance) under the Federal Analogue Act. In this case, sale or possession of 25I-NBOMe with the intent of human consumption would be illegal.
• Virginia, Louisiana, and Florida have specifically scheduled 25I-NBOMe as a Schedule I controlled substance.
• All NBOMe substituted phenethylamines are controlled in Russia.

In other countries, however, 25I-NBOMe is completely unscheduled and freely available to anybody with an internet connection. If you wish to obtain this substance despite the risks involved you can literally type “buy 25I-NBOMe” into google and find several legitimate vendors on the very first page.

Please keep in mind however that 25I-NBOMe is NOT being sold by anybody specifically for the purposes human consumption as this would be genuinely illegal within most if not all countries.

Reader submitted trip reports:

• Unknown dosage / 1 tabs - Prolonged unity and messiah syndrome at school by H0bcnd2
  
• Unknown dosage / 3 tabs - Ego death and a total break through in the snow by H0bcnd2
• 1000ug / 1 tab - No sense of enlightenment but absolutely breath taking visuals by Anonymous
• Unknown dosage - Ego death and becoming one with a singular entity by Anonymous

Conclusion:

In conclusion, 25I-NBOMe is an extremely interesting psychedelic but does not quite compare in terms of visual and cognitive depth if you have access to classical psychedelics such as genuine LSD, DMT and psilocin.

I will not be seeking this substance out again but experimenting with it has certainly been an interesting and enjoyable experience.
Please go ahead and let me know if you agree or disagree with any particular points contained within this article by using the comment system below.

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