Disregard Everything I Say

Dosage (oral)
Threshold : 2-5mg
Light : 5-15mg
Common : 10-25mg
Strong : 20-30mg
Heavy : 30+mg

Duration (oral)
Total duration : 5 - 8 hours
Onset : 20 - 90 minutes
Come up : 20 - 30 minutes
Peak : 3 - 7 hours
Come down : 1 - 2 hours
After effects : 2 - 4 hours

2C-I or 2,5-dimethoxy-4-iodophenethylamine is a psychedelic phenethylamine of the 2C-x family. It was first synthesized by Alexander Shulgin. It was described in Shulgin’s 1991 book PiHKAL: A Chemical Love Story. The drug is used recreationally for its psychedelic and entactogenic effects and is sometimes confused for the analog 25I-NBOMe. 2C-I is commonly sold in its hydrochloride salt form, which is a fluffy, sparkling, white powder, which can sometimes be pressed into tablet form. 2C-I has been explored as a potential stimulant nootropic in doses between 1-8mg.

In terms of its chemistry, 2C-I is a substituted phenethylamine with methoxy groups attached carbons R2 and R5 as well as an iodine molecule attached to carbon R4. It is thought to have efficacy at the 5-HT2A receptor as a partial agonist.

The 2C-I experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical effects:

The physical effects of 2C-I can be broken down into five components all of which progressively intensify proportional to dosage. These are described below and generally include:

• Spontaneous tactile sensations - The body high of 2C-I is manifested as one of the most proportionally intense in comparison to almost all of the classical psychedelics. The sensation itself can be described as an intense and slightly uncomfortable energetic pins and needles sensation that constantly encompasses a person’s entire body. It is usually felt over every square inch of the skin but occasionally manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves. Alongside of this, many users commonly report that the body high can be particularly uncomfortable and sometimes accompanied by dysphoric aches and urges to shift the position of one’s body and prolonged tensing of unusual combinations of muscle groups.
• Euphoria - Feelings of frequent but unpredictable rushes of warm physical euphoria are extremely common and very pleasurable. These move from the top of the head downwards before envoloping ones whole body.
• Stimulation - In terms of its effects on the physical energy levels of the tripper, 2C-I is usually considered to be very energetic and stimulating in a fashion that is quite comparable to that of MDMA although encouraged instead of forced.
• Increased bodily control
• Enhancement of touch
• Nausea - Mild to extreme nausea is consistently reported when consumed in moderate to high dosages and either passes once the tripper has vomited or gradually fades by itself as the peak sets in.
• Loss of temperature regulation
• Head aches - Some users report mild but uncomfortable head pressures which can occasionally intensify during the offset of the experience.

Cognitive effects:

The head space of 2C-I is described by many as one which is relatively normal in its thought processes even at moderate to high dosages. It is often said to lack insight when compared to that of 2C-E, 2C-B and LSD.
The total sum of these cognitive components regardless of the setting generally includes:

• Increased empathy, love and sociability - This component is consistently manifested only in the context of social settings in which one is within the company of others. These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA and 2C-B but still prove strong enough to provide long lasting therapeutic effects.
• Time distortion
• Feelings of fascination, importance and awe
• Sexual arousal
• Enhancement of current mind state
• Ego suppression, loss and death
• States of unity and interconnectedness

Visual effects:

Enhancements

2C-I presents a full and complete array of possible visual enhancements which generally includes:

• Increased visual acuity
• Enhancement of colour
• Enhanced pattern recognition

Distortions

2C-I presents a full and complete array of possible visual distortions which generally includes:

• Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as simplistic and bland in detail, slow and smooth but sometimes jittery in motion, static in appearance and unrealistic/cartoon-like in style.
• Tracers
• Symmetrical texture repetition - In comparison to other psychedelics such as LSD and 2C-E this particular effect is bland and simplistic.
• Colour shifting
• Scenery slicing

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of LSD or 2C-B than that of 2C-E, psilocin, or ayahuasca although it is much more bland and less detailed. They can be comprehensively described as unstructured in their organization, algorithmic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, both soft and sharp in their edges as well as equally rounded and angular in their corners. They seem high in algorithmic visuals such as fractals and at higher dosages are significantly more likely to result in states of Level 7A visual geometry over Level 7B.

Hallucinatory states

Like LSD, while 2C-I is capable of producing a full range of low and high level hallucinatory states, this is extremely rare and inconsistent at higher levels but common at lower and generally includes the following effects:

• External hallucinations - The experience of effects such as open eye transformations are common within 2C-I but not consistent.
• Internal hallucinations - Although 2C-I is technically capable producing of hallucinatory states in a fashion that is on par with psilocin or DMT in its vividness and intensity, in comparison, these effects are extremely rare and inconsistent. Whilst traditional psychedelics such as LSA, Ayahuasca and Mescaline will induce internal hallucinations near consistently at level 5 geometry and above, 2C-I hallucinations will not extend beyond imagery and higher dosages will for most will simply go straight into Level 7A visual geometry. This lack of consistently induced hallucinatory breakthroughs means that for most, 2C-I is simply not as deep of an experience as certain other psychedelics.

Auditory effects:

The auditory effects of 2C-I are common in their occurrence and exhibit a full range of effects which commonly include:

• Enhancements
• Distortions
• Hallucinations

Health effects, addiction potential and tolerance:

The toxicity and long term health effects of recreational 2C-I use does not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 2C-I is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried 2C-I within the psychedelic community suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).

There is a short period of tolerance after 2C-I use. Using 2C-I two days in a row is likely to lead to a diminished experience the second day. However, this effect is nearly non-existent when spaced 5-7 days apart.

Legal issues:

• European Union: In December 2003, the European Council issued a binding order compelling all EU member states to ban 2C-I within three months.
• Denmark: It is a controlled substance.
• Germany: It is a controlled substance.
• Greece: It is a controlled substance.
• Ireland: The drug is a controlled substance.
• Italy: It is a controlled substance.
• Netherlands: It is a controlled substance.
• Poland: It is a controlled substance.
• Sweden: Sveriges riksdag added 2C-I to schedule I (“substances, plant materials and fungi which normally do not have medical use”) as narcotics in Sweden as of March 16, 2004. 
• United Kingdom: It is controlled as a Class A substance.
• USA: As of July 9, 2012, in the United States, 2C-I is a Schedule I substance under the Synthetic Drug Abuse Prevention Act of 2012, making possession, distribution and manufacture illegal.

Conclusion:

2C-I is a worthwhile experience but is not as deep as other drugs of the same family. It is a substance which works better for some than others. For example, while many find it to be extremely uncomfortable others find it perfect for recreational use in public and social environments. 

This subjective effect breakdown was made in collaboration with PsychonautWiki admin, Oscarette. 

Click here for a more comprehensive breakdown.

Dosage (oral)

Threshold : 1-3mg
Light : 2-5mg
Common : 6-10mg
Strong : 10-16mg
Heavy : 16+mg

Dosage (insufflated)

Threshold : 0.5-2mg
Light : 1-3mg
Common : 3-6mg
Strong : 5 - 10mg
Heavy : 12+mg

Duration (oral)

Onset : 1 - 3 hrs
Come up : 2 - 4 hrs
Peak : 5 - 8 hours
Come down : 1 - 3 hours
After effects : 3 - 6 hours

Duration (insufflated)

Onset : 1 - 2 minutes
Come up : 20 - 60 minutes
Peak : 4 - 6 hours
Come down : 2 - 3 hours
After effects : 2 - 4 hours

2C-P (2,5-dimethoxy-4-propylphenethylamine) is a synthetically produced psychoactive drug usually sold by online research chemical vendors. The substance itself is classed as a psychedelic phenethylamine of the 2C-x family and was first synthesized by Alexander Shulgin in 1974.

Like many 2c-x substances, this drug is a highly dose sensitive psychedelic known for its entactogenic effects, powerful (yet bright) visuals, and intense body load. It is often described by users as a chemical which is very similar to that of 2C-E yet distinct in its own effects. This drug may be overly intense for those who are not already experienced with psychedelics. This is something which is consistently attributed to its often overwhelmingly powerful effects and extremely long duration of 10 - 20 hours.

The 2C-P experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical effects:

The physical effects of 2C-P can be broken down into six components all of which progressively intensify proportional to dosage. These are described below and generally include:

• Spontaneous tactile sensations - The body high of 2C-P is intense but, in comparison to 2C-E or 2C-B, it can be considered mild though is still capable of becoming very powerful and highly physically euphoric. It is similar yet distinct from the body high experienced on 2C-E, 2C-B, and LSD. The sensation itself can be described as intense and will manifest itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves. This is coupled by an equally intense yet slightly uncomfortable energetic pins and needles sensation that constantly encompasses a person’s entire body and a slight warm glow that manifests itself much less consistently than the other two physical components. All of these are capable of becoming very physically euphoric but can be described as proportionally intense with the visual and cognitive effects when compared to LSD.
• Stimulation - In terms of its effects on the physical energy levels of the tripper 2C-P is usually considered to be very energetic and stimulating in a fashion that is quite comparable to that of MDMA.
• Sexual arousal - A commonly felt physical component of the 2C-P trip is the way in which it heightens and enhances sexual arousal. When experienced, this sensation is not overwhelming or out of control but simply remains something that the tripper is constantly aware of. If sexual activities of any kind are engaged in, they are found to be immensely more pleasurable beyond anything that could be possible sober with orgasm becoming difficult to reach but completely possible to obtain. When obtained, the orgasm itself is capable of temporarily increasing the effects of the drug. This is most commonly experienced as visual effects dramatically increasing in a short yet powerful burst.
• Increased bodily control
• Enhancement of touch
• Nausea - Mild to extreme nausea is consistently reported when consumed in moderate to high dosages and either passes once the tripper has vomited or gradually fades by itself as the peak sets in.
• Loss of temperature regulation

Cognitive effects:

The head space of 2C-P is described by many as one which is both insightful and relatively normal in its thought processes even at moderate to high dosages.

The total sum of these cognitive components regardless of the setting generally includes:

• Enhancement of current mind state
• Acceleration of thought
• Feelings of fascination, importance and awe
• Time distortion
• Introspection
• Outrospection
• Removal of cultural filter
• Conceptual thinking
• Direct communication with the subconsious
• Ego suppression, loss and death
• Thought loops
• Feelings of interdependent opposites
• Delusions
• States of unity and interconnectedness

Visual effects:

Enhancements

2C-P presents a full and complete array of possible visual enhancements which generally include:

• Increased visual acuity
• Enhancement of colours
• Enhanced pattern recognition

Distortions

As for visual distortions and alterations, effects experienced are detailed below:

• Visual drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance, and unrealistic/ cartoon like in style.
• Tracers
• After images
• Texture repetition
• Colour shifting
• Scenery slicing

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT or ayahuasca than that of LSD, 2C-B, or 2C-I. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, sharp in their edges and equally rounded and angular in their corners. They give off a contradictory natural and synthetic feel to them that at higher dosages are significantly more likely to result in states of Level 7B visual geometry over Level 7A. There seems to be visual geometry that is distinct from 2C-E, psilocin and ayahuasca and can be described as faster moving and more intense in proportion to the present cognitive and physical effects than 2C-E.

Hallucinatory states

2C-P produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the phenethylamine family. These effects include:

• External hallucinations
• Internal hallucinations - In comparison to other psychedelics such as LSD, 2C-P is extremely high in hallucinations embedded within visual geometry. This particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.

Auditory effects:

The auditory effects of 2C-P are more common in their occurrence than many commonly used psychedelics and exhibit a full range of effects which commonly include:

• Enhancements
• Distortions
• Hallucinations

Health effects, addiction potential and tolerance:

The toxicity and long term health effects of recreational 2C-P use does not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 2C-P is a research chemical with very little history of human usage. 

Anecdotal evidence from people who have tried 2C-P within the psychedelic community suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).

2C-P does not seem to be physically addictive and many users experience a self-regulating quality even though there is no real tolerance attributed to this drug (meaning that it could potentially be used multiple days in a row if somebody chose to do so). However, due to its slow onset and long duration, usage of this substance in this manner in unlikely to be favourable.

Like 2C-E and unlike many other psychedelics, 2C-P has the ability to be redosed after peaking quite successfully. For most drugs, there will be substantially diminished effects from the second dose, but there is minimal with 2C-P. However, due to the rather long delay before come up and long duration, many users of 2C-P may find this impractical.

Legal Issues:

Possession and sale of 2C-P is unscheduled in most countries.

• UK: 2C-P is a Class A drug.
• USA: 2C-P is a Schedule I drug.

Conclusion:

The subjective effects breakdown contained within this article was written and contributed by the PsychonautWiki admin known as Cocoanatta. 

As for the substance itself, this drug is perhaps one of the most interesting 2C-X compounds available today through the online market. It is extremely powerful in its effects and completely comparable with that of other more traditional psychedelic drugs such as LSD.

 Click here for a more comprehensive breakdown.

Dosage (oral)

Threshold : 2-5mg
Light  : 5-15mg
Common : 15-25mg
Strong : 25-40mg
Heavy : 40+mg

Duration (oral)

Onset : 20 - 90 minutes
Come up : 15 - 30 minutes
Peak : 3 - 7 hours
Come down : 1 - 2 hours
After effects : 2 - 4 hours

Dosage (insufflated)

Threshold : ~1mg
Light  : 1 - 5mg
Common : 5-10mg
Strong : 10 - 15mg
Heavy : 15+mg

Warning!!! (2C-B insufflation is extremely painful)

Duration (insufflated)

Onset : 1 - 2 minutes
Come up : 10 - 20 minutes
Peak : 2 - 4 hours
Come down : 1 - 2 hours
After effects : 2 - 4 hours

2C-B (4-bromo-2,5-dimethoxyphenethylamine) is a psychedelic phenethylamine of the 2C-x family. It was first synthesized by Alexander Shulgin in 1974. 

This substance first saw use among the psychiatric community as an aid during therapy. It was considered one of the best drugs for this purpose because of its short duration, relative absence of side effects, and comparably mild nature. 

Like many 2c-x substances, this drug is a highly dose sensitive psychedelic known for its entactogenic effects, bright visuals, and intense body load. This substance is often described by users as feeling half way between LSD and MDMA. Many reports suggest that while 2C-B’s entactogenic effects are less pronounced than MDMA, the visual effects are described as more pronounced and colourful.

The 2C-B experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical Effects:

The physical effects of 2C-B can be broken down into five components all of which progressively intensify proportional to dosage. These are described below and generally include:

• Spontaneous tactile sensations - The body high of 2C-B is not necessarily one of the most intense, but is instead one of the most complex compared to other psychedelics, sharing components of MDMA, 2C-E, and LSD. This is first characterized by an intense soft warm glow that grows over the body and is capable of becoming extremely physically euphoric. This is most similar to MDMA and is consistently manifested throughout the experience. This is contrasted by an intensely pleasurable yet sharp, cold electric tingling sensation which moves up and down the body. This is most similar to LSD and is also consistently manifested throughout the trip. The final physical effect noticed throughout the experience is an intense and slightly uncomfortable, energetic pins and needles sensation that manifests itself in the form of a continuously shifting and tingling sensation that travels up and down the body in spontaneous waves. This is most similar to 2C-E and is not entirely consistent throughout the trip.
• Stimulation - In terms of its effects on the physical energy levels of the tripper, 2C-B is usually considered to be very energetic and stimulating in a fashion that is quite comparable to that of MDMA.
• Increased bodily control
• Enhancement of touch
• Nausea - Mild to extreme nausea is reported when consumed in moderate to high dosages and either passes once the tripper has vomited or gradually fades by itself as the peak sets in.

Cognitive Effects:

The head space of 2C-B is described by many as one which is both insightful and relatively normal in its thought processes even at moderate to high dosages.

The total sum of these cognitive components regardless of the setting generally includes:

• Introspection - This component is consistently manifested only in the context of a non-social setting in which the user is alone.
• Increased empathy, love and sociability - These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA but still prove stronger and more consistent than other psychedelics of any class. This is capable of providing long lasting therapeutic effects.
• Sexual arousal
• Acceleration of thought
• Time distortion
• Feelings of fascination, importance and awe
• Conceptual thinking
• Connectivity of thought
• Enhancement of current mind state
• Removal of cultural filter
• Ego suppression, loss and death

Visual Effects:

Enhancements

2C-B presents a full and complete array of possible visual enhancements which generally include:

• Increased visual acuity
• Enhancement of colours
• Enhanced pattern recognition

Distortions

As for visual distortions and alterations, effects experienced are detailed below:

• Visual drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance, and unrealistic/ cartoon like in style.
• Tracers
• After images
• Texture repetition
• Colour shifting
• Scenery slicing

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of LSD than that of 2C-E, psilocin, or ayahuasca. They can be comprehensively described as unstructured in their organization, algorithmic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, sharp in their edges and angular in their corners. They seem high in algorithmic visuals such as fractals and at higher dosages are significantly more likely to result in states of Level 7A visual geometry over Level 7B.

Hallucinatory States

Like LSD, while 2C-B is capable of producing a full range of low and high level hallucinatory states, this is extremely rare and inconsistent at higher levels but common at lower and generally includes the following effects:

• External hallucinations
• Internal hallucinations - Although 2C-B is technically capable producing of hallucinatory states in a fashion that is on par with psilocin or DMT in its vividness and intensity, in comparison, these effects are extremely rare and inconsistent. Whilst traditional psychedelics such as LSA, Ayahuasca and Mescaline will induce internal hallucinations near consistently at level 5 geometry and above, 2C-B will for most go straight into Level 7A visual geometry. This lack of consistently induced hallucinatory breakthroughs means that for most, 2C-B is simply not as deep of an experience as certain other psychedelics.

Auditory Effects:

The auditory effects of 2C-B are more common than some psychedelics in their occurrence and are capable of producing a full range of effects which commonly include:

• Enhancements
• Distortions
• Hallucinations

Physical Health Effects, Potential Addiction and Tolerance:

There is no current data for the lethal dosage of 2C-B, but it is thought to be extremely high. Alexander Shulgin reported in his book PIHKAL that an accidental dosage of 100mg resulted in no physical or psychological damage.

Since the invention of this substance in 1974, not a single person has yet to accidentally or deliberately experience a fatal overdose with this substance. This suggests that 2C-B is very safe but please keep in mind that clinical studies assessing its safety have not been performed in any scientific context.

In terms of its tolerance, 2C-B can be redosed repeatedly with little to no loss in the strength of its subjective effects. This means that is theoretically possible to become addicted to it but thanks to its psychedelic properties users experience a powerful self-regulating quality to this substance.

Legal Issues:

• Australia: Possession, production, and sale is illegal.
• Belgium: Possession, production, and sale is illegal.
• Brazil: Possession, production, and sale is illegal.
• The EU: 2C-B is a Schedule II drug.
• Canada: 2C-B is a Schedule III drug.
• Estonia: 2C-B is a Schedule I drug.
• Finland: Possession, production, and sale is illegal.
• Japan: Possession, production, and sale is illegal.
• The Netherlands: Possession, production, and sale is illegal.
• Norway: 2C-B is a Schedule II drug.
• Poland: 2C-B is a Schedule I drug.
• Russia: Possession, production, and sale is illegal.
• Spain: 2C-B is a Category 2 drug.
• Sweden: 2C-B is a Schedule I drug.
• Switzerland: Possession, production, and sale is illegal.
• UK: 2C-B is a Class A drug.
• USA: 2C-B is a Schedule I drug.

Reader submitted trip reports:

• 150mg MDMA + 20mg 2C-B - I designed it this way myself by Oscarette

Conclusion:

The main bulk of the 2C-B subjective effects breakdown for this particular article was not written by myself but the PsychonautWiki admin known as Cocoanatta. I have tried 2C-B on two separate occasions and can confirm that the descriptions are indeed accurate.

As for the substance itself, 2C-B is an incredibly fun and therapeutically beneficial substance. This makes it extremely useful for both recreational and introspective purposes. It is, in my opinion, the most suitable psychedelic for a beginner in existence due to its clear, euphoric headspace and proportionally mild visual effects in comparison to that of LSD or mushrooms.

Click here for a more comprehensive breakdown.

Duration,
Total : 6 - 10 hrs
Onset : 15 - 120 mins
Plateau : 2 - 4 hrs
Coming Down : 1 - 4 hrs

Dosage,
Threshold : 50 - 250 ug (micrograms)
Light : 200 - 600 ug
Common : 500 - 800 ug
Strong : 700 - 1500 ug

25I-NBOMe can be fatal at heavy doses.^[1] It is strongly discouraged to take large amounts of this substance or to snort it.

25I-NBOMe or 2C-I-NBOMe is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-I.

It has nearly no history of human use prior to 2010 when it first became popular due its ease of purchase from online research chemical vendors.

25I-NBOMe was discovered in 2003 by Ralf Heim at the Free University of Berlin. It differs from 2C-I structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group as shown in the image above. This change in structure results in a sixteen fold increase in potency when compared to 2C-I, allowing even the most extreme of dosages to fit in liquid form onto tabs and blotter paper (which people often mistake for LSD).

There are, however, methods of differentiating between LSD and adulterants like 25I-NBOMe with and without test kits.

For example, one of the key differences between 25I-NBOMe and LSD is that this substance is only active when taken through a sublingual or insufflated route. This means that in order to get the full effects, 25I-NBOMe blotter paper must be lightly chewed on within the mouth for 10 - 20 minutes and never immediately swallowed.

Insufflation, however, is not recommended due to the amount of people who have suffered through dangerous and often fatal overdoses due to this route of administration.

25I-NBOMe is pharmacologically unique when compared to other psychedelics through the way in which it is one of the only full agonists for the human 5ht2a receptor in existence. In comparison, classical psychedelics such as LSD, DMT and psilocin can only be considered partial agonists.

This difference in receptor affinity results in an unusual and qualitatively different trip which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical effects:

The physical effects of 25I-NBOMe can be broken down into six components all of which progressively intensify proportional to dosage. These are described below and generally include:

• Sublingual numbing - assuming the substance has been taken sublingually, the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very obvious feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed. This is the key difference when it comes to determining whether your blotter paper contains LSD or one of the NBOMe series.
• Spontaneous tactile sensations - the body high itself can be described as a generally mild, all-encompassing, soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of euphoria that become longer and more drawn out proportional to the dosage consumed.
• Decreased bodily weight - in terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness.
• Stimulation - in terms of its effects on the physical energy levels of the tripper 25I-NBOMe is usually considered to be very energetic and stimulating. For most people, this substance induces a unique type of physical stimulation which can be described as feeling extremely energetic but in a way which does not force the tripper to move unless they genuinely choose to do so. For others however, the stimulation can be quite uncontrollable, occasionally resulting in bodily shakes and a grinding of the teeth comparable to that of MDMA and traditional stimulants such as amphetamine.
• Vasoconstriction - this is defined as the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels and is triggered through the way in which 25I-NBOMe’s target receptor (5-HT2A) modulates both vasoconstriction and vasodilation among its many other functions. It can be described as feelings of tightness within one’s arms and legs.
• Nausea - as the tripper begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, but passes once this has either happened or the trip begins to fully set in. In comparison to other psychedelics such as psilocin, LSD, 2C-E and 2C-I, this could actually be very considered very mild in its intensity.

Cognitive effects:

The head space of 25I-NBOMe is described by many as remarkably light and underwhelming in comparison to the classical psychedelics. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout low to moderate dosages. At high dosages however, mild to overwhelming cognitive alterations become present.

The most prominent of these cognitive effects generally include:

• Introspection - this component is consistently manifested only in the context of a non-social setting in which the user is alone.
• Acceleration of thought
• Ego suppression, loss and death
• Time distortion
• Feelings of fascination, importance and awe
• Conceptual thinking
• Connectivity of thought
• Enhancement of current mind state
• Removal of cultural filter
• Increased empathy, love and sociability - the entactogenic effects range from mild to powerful, but are inconsistently manifested. Entactogenic effects for people who try this substance usually become prominent in the presence of others. These feelings of increased sociability, love and empathy do not seem to be quite as strong or profound as those found within other entactogens (such as MDMA, 2C-B and AMT)

Visual effects:

Enhancements

25I-NBOMe presents a full and complete array of possible visual enhancements which generally include:

• Increased visual acuity
• Enhancement of colours
• Enhanced pattern recognition

Distortions

The visual distortions and alterations which are experienced are detailed below:

• Visual drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in their appearance and unrealistic/cartoon like in style.
• Tracers
• After images
• Texture repetition - In comparison to other psychedelics such as LSD or psilocin, this particular visual alteration is significantly more basic and less intricate in style but still distinctively present.

Geometry

The visual geometry that is present throughout this trip is often described as similar in appearance to that of LSD. They can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colourful in scheme, glossy in colour, sharp around the edges and mostly rounded across their corners. In comparison to other more commonly used psychedelics, they can be described as significantly more intricate than the visual geometry found within 2C-I and most of the 2C-x family and are completely on par with LSD, Psilocin and DMT at appropriately high dosages.

In terms of their behaviour, 25I-NBOMe’s geometry leads onto Level 7A visual geometry with Level 7B remaining so far unconfirmed within this substance. They also seem to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelops the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it.

Hallucinatory states

25I-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. However, level 4 hallucinatory breakthroughs are reported but very uncommon and inconsistent in comparison to other more commonly used psychedelics such as psilocin, 2C-E and DMT.

These effects include:

• External hallucinations
• Internal hallucinations - this particular effect commonly contains hallucinations within scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.

Auditory effects:

The auditory effects of 25I-NBOMe are common in their occurrence and exhibit a full range of effects which commonly include:

• Enhancements
• Distortions
• Hallucinations

Health effects, addiction potential and tolerance:

25I-NBOMe is a very new substance and little is known about its pharmacological or behavioural risks. The LD50 is not known. Some deaths have been attributed to 25I-NBOMe overdoses caused by improper handling and uneducated use of this substance. Its recent widespread use suggests that death is primarily caused from overdoses and not from ordinary doses, particularly from insufflation.

The fact that 25I-NBOMe is active in the microgram range is likely a contributing factor since this makes measuring doses significantly more difficult. 

It’s worth noting that although many 5-HT2A agonists have documented safety, none of these have been full agonists so their safety data cannot be applied to 25I-NBOMe.

In terms of its addictive potential, 25I-NBOMe has not been studied formally but due to its immediate tolerance build up which lasts up to 2 - 3 weeks after the experience, it is essentially impossible to use this substance compulsively.

Legal issues:

• 25I-NBOMe is unscheduled under United States federal law. However, it could possibly be considered an analog of 2C-I (a Schedule I controlled substance) under the Federal Analogue Act. In this case, sale or possession of 25I-NBOMe with the intent of human consumption would be illegal.
• Virginia, Louisiana, and Florida have specifically scheduled 25I-NBOMe as a Schedule I controlled substance.
• All NBOMe substituted phenethylamines are controlled in Russia.

In other countries, however, 25I-NBOMe is completely unscheduled and freely available to anybody with an internet connection. If you wish to obtain this substance despite the risks involved you can literally type “buy 25I-NBOMe” into google and find several legitimate vendors on the very first page.

Please keep in mind however that 25I-NBOMe is NOT being sold by anybody specifically for the purposes human consumption as this would be genuinely illegal within most if not all countries.

Reader submitted trip reports:

• Unknown dosage / 1 tabs - Prolonged unity and messiah syndrome at school by H0bcnd2
  
• Unknown dosage / 3 tabs - Ego death and a total break through in the snow by H0bcnd2
• 1000ug / 1 tab - No sense of enlightenment but absolutely breath taking visuals by Anonymous
• Unknown dosage - Ego death and becoming one with a singular entity by Anonymous

Conclusion:

In conclusion, 25I-NBOMe is an extremely interesting psychedelic but does not quite compare in terms of visual and cognitive depth if you have access to classical psychedelics such as genuine LSD, DMT and psilocin.

I will not be seeking this substance out again but experimenting with it has certainly been an interesting and enjoyable experience.
Please go ahead and let me know if you agree or disagree with any particular points contained within this article by using the comment system below.

Click here for a more comprehensive breakdown.

Onset : 20 - 90 minutes
Duration : 6 - 10 hours
Normal After Effects : 2 - 6 hours

Light : 5 - 10 mg
Common : 10 - 15 mg
Strong : 15 - 30 mg
Heavy : 30 - 40 mg +

2C-E (2,5-dimethoxy-4-ethylphenethylamine) is a psychedelic and phenethylamine of the 2C family. Its chemical synthesis was first published in 1991 within the book PiHKaL: A Chemical Love Story by Dr. Alexander Shulgin and Ann Shulgin. This was a groundbreaking book that included detailed synthesis instructions for over 200 psychedelic compounds (most of which Shulgin discovered himself) including bioassays, dosages, and other commentary. For those who are interested, 2C-E’s specific entry, synthesis, and qualitative commentary can be found here.

The mechanism that produces the psychedelic effects of 2C-E is a direct result from its action as a 5-HT2A serotonin receptor agonist in the brain. It is a mechanism of action shared by all other hallucinogenic tryptamines and phenethylamines.

Many people have reported that the general effects of 2C-E are similar to those of the other psychedelic phenethylamines, but far more intense in terms of its physical body load and visual effects. The experience is often described as similar in appearance to LSD, and many reports indicate that the effects of this particular chemical may be overly intense for those who are not already experienced with psychedelics.

The 2C-E experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical Effects:

The physical effects of 2C-E can be broken down into five components all of which progressively intensify proportional to dosage. These are described below and generally include:

• Spontaneous tactile sensations - The body high of 2C-E is manifested as one of the most proportionally intense in comparison to almost all of the classical psychedelics. This is something which is only beaten in terms of its overwhelming forcefulness by high dose AMT and 5-MeO-DMT experiences. The sensation itself can be described as an intense and slightly uncomfortable energetic pins and needles sensation that constantly encompasses a person’s entire body. It is usually felt over every square inch of the skin but occasionally manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves. Alongside of this, many users commonly report that the body high can be particularly uncomfortable and sometimes accompanied by urges to shift the position of one’s body and prolonged tensing of unusual combinations of muscle groups.
• Stimulation - In terms of its effects on the physical energy levels of the tripper, 2C-E is usually considered to be very energetic and stimulating in a fashion that is quite comparable to that of MDMA.
• Increased bodily control
• Enhancement of touch
• Nausea - Mild to extreme nausea is consistently reported when consumed in moderate to high dosages and either passes once the tripper has vomited or gradually fades by itself as the peak sets in.
• Loss of temperature regulation

Cognitive Effects:

The head space of 2C-E is described by many as one which is both insightful and relatively normal in its thought processes even at moderate to high dosages.

The total sum of these cognitive components regardless of the setting generally includes:

• Introspection - This component is consistently manifested only in the context of a non-social setting in which the user is alone.
• Increased empathy, love and sociability - This component is consistently manifested only in the context of social settings in which one is within the company of others. These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA and 2C-B but still prove strong enough to provide long lasting therapeutic effects.
• Acceleration of thought
• Time distortion
• Feelings of fascination, importance and awe
• Sexual arousal
• Conceptual thinking
• Connectivity of thought
• Enhancement of current mind state
• Removal of cultural filter
• Ego suppression, loss and death

Visual Effects:

Enhancements

2C-E presents a full and complete array of possible visual enhancements which generally include:

• Increased visual acuity
• Enhancement of colours
• Enhanced pattern recognition

Distortions

As for visual distortions and alterations, the effects experienced are detailed below:

• Visual drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance, and unrealistic/cartoon like in style.
• Tracers
• After images
• Texture repetition
• Colour shifting
• Scenery slicing

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT or ayahuasca than that of LSD, 2C-B, or 2C-I. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, sharp in their edges, and equally rounded and angular in their corners. They give off a contradictory natural and synthetic feel to them that at higher dosages are significantly more likely to result in states of Level 7B visual geometry over Level 7A.

Hallucinatory States

2C-E produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the the phenethylamine family. These effects include:

• External hallucinations
• Internal hallucinations - In comparison to other psychedelics such as LSD, 2C-E is extremely high in hallucinations embedded within visual geometry. This particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.

Auditory Effects:

The auditory effects of 2C-E are common in their occurrence and exhibit a full range of effects which commonly include:

• Enhancements
• Distortions
• Hallucinations

Health Effects, Potential Addiction and Tolerance:

The toxicity and long term health effects of recreational 2C-E use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 2C-E is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried 2C-E within the psychedelic community suggest that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).

The biggest danger with this substance seems to be confusing it with other more potent psychedelics such as Bromo-DragonFLY as 2C-E which is active in the 200 - 800 microgram range. This means that it is roughly as potent as LSD and extremely dangerous if taken in place of 2C-E, which has resulted in fatal overdoses on multiple separate occasions thanks to the accidental mislabelling of bags from research chemical vendors. There are cases in the media of people ordering 2-CE, among other research chemicals, from online vendors, and receiving Bromo-DragonFLY instead.

2C-E does not seem to physically addictive but could potentially become habit-forming as there is no real tolerance attributed to this drug– meaning that it could potentially be used multiple days in a row if somebody chose to do so. This can be prevented by manually limiting your usage of the drug and is practically unheard of, with most users noting that the desire to use them can actually decrease with use thanks to its powerfully introspective and mentally therapeutic effects.

Legal Issues:

• As of July 9, 2012, 2C-E is a Schedule I substance under the Food and Drug Administration Safety and Innovation Act of 2012, making possession, distribution and manufacture illegal in the United States.
• As of April 8, 2007, Denmark added 2C-E to the list of Schedule I controlled substances.
• New Zealand has a catch-all Analogues section in Schedule 3 / Class C of their drug laws that makes 2C-E a Schedule 3 compound.
• In Sweden, 2C-E has been controlled since Oct 1, 2004.
• As of 2002, 2C-E is illegal in the United Kingdom and a Class A controlled substance under The Misuse of Drugs Act. 

Elsewhere in the world, it is completely legal. If you want to try 2C-E despite full knowledge of the legal risks it can be purchased online through various research chemical vendors of which I cannot legally mention the names of. This means that if you want to do this, you will have to find a source for yourself using the power of Google search.

Conclusion:

In conclusion, I was extremely impressed with 2C-E and it exceeded my expectations many times over. I was originally expecting a poor man’s LSD with psychedelic visuals but no true hallucinatory states. Instead I found myself with a substance that is more comparable to mushrooms and extremely useful for both psychonautical exploration and recreational activities such as raves, festivals, and parties (for those who are already experienced with the substance). It is even useful when taken at very low sub threshold dosages as a motivating background stimulant as I actually wrote this entire article on approximately 0.07mg and it genuinely helped me keep the words flowing and maintain a strong sense of focus.
Alexander Shulgin has been quoted as saying “Someday, the full character of 2C-E will be understood, but for the moment, let it rest as being a difficult and worth-while material. A very much worth-while material.” 

This is a statement which I completely agree with and I genuinely hope that this article has contributed to increasing the psychedelic community’s understanding of this fascinating substance. 

Over the upcoming months I will definitely be slowly working my way through Shulgin’s magical half-dozen (which can be found here) and documenting each of their subjective effects in as much detail as human English will possibly allow me to.

Click here for a more comprehensive breakdown.