25I-NBOMe, broken down and described

Duration,
Total : 6 - 10 hrs
Onset : 15 - 120 mins
Plateau : 2 - 4 hrs
Coming Down : 1 - 4 hrs
Dosage,
Threshold : 50 - 250 ug (micrograms)
Light : 200 - 600 ug
Common : 500 - 800 ug
Strong : 700 - 1500 ug
25I-NBOMe or 2C-I-NBOMe is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-I.
It has nearly no history of human use prior to 2010 when it first became popular due its ease of purchase from online research chemical vendors.
25I-NBOMe was discovered in 2003 by Ralf Heim at the Free University of Berlin, it differs from 2C-I structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group as shown in the image above. This change in structure results in a sixteen fold increase in potency when compared to 2C-I, allowing even the most extreme of dosages to fit in liquid form onto tabs and blotter paper which people often mistake for LSD.
There are, however, methods of differentiating between LSD and adulterants like 25I-NBOMe with and without test kits.
For example, one of the key differences between 25I-NBOMe and LSD is that this substance is only active when taken through a sublingual or insufflated route. This means that in order to get the full effects, 25I-NBOMe blotter paper must be lightly chewed on within the mouth for 10 - 20 minutes and never immediately swallowed.
Insufflation however is not recommended due to the amount of people who have suffered through dangerous and often fatal overdoses thanks to this route of administration.
25I-NBOMe is pharmacologically unique when compared to other psychedelics through the way in which it is one of the only full agonists for the human 5ht2a receptor in existence. In comparison, classical psychedelics such as LSD, DMT and Psilocin can only be considered partial agonists. This difference in receptor affinity results in an unusual and qualitatively different trip which is broken down and described below…
Physical effects:
Assuming the substance has been taken sublingually, the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very obvious feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed.
This is the key difference when it comes to determining whether your blotter paper contains LSD or 25I-NBOMe.
As the tripper begins to come up, nausea is not uncommon and can sometimes result in initial vomiting but passes once this has happened or the trip begins to fully set in. However, in comparison to other psychedelics such as Psilocin, LSD, 2C-E and 2C-I this could actually be very considered very mild in intensity.
For most people this substance induces a unique type of physical stimulation which can be described as feeling extremely energetic but in a way which does not force the tripper to move unless they genuinely choose to. This is a very different experience when compared to other stimulating psychedelics such as AMT, MDMA and the 2Cx family which at high doses, will leave a person uncontrollably shaking and vibrating should they attempt to ignore the stimulation and sit still.
For a certain percentage of people however the stimulation can be quite uncontrollable, occasionally resulting in bodily shakes and a grinding of the teeth comparable to that of MDMA and traditional stimulants such as Amphetamine. This cannot be prevented but made very comfortable and quite bearable with the addition of chewing gum.
The body high itself can be described as a generally mild, all encompassing soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of euphoria that become longer and more drawn out proportional to the dosage consumed.
In terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness.
This is commonly accompanied by strong feelings of physical autonomy and a sense of disconnection from the body which makes it feel as if the body is not your own and partially or completely moving under its own accord.
Along side this; there is also a mild reduction in a person’s ability to use fine and gross motor control, making it difficult to perform physical tasks. However, in comparison to other psychedelics such as Psilocin, LSD and 2C-I this could actually be very considered very mild and relatively functional.
It is worth noting that an undetermined percentage of people who experiment with this drug will experience negative physical side effects such as a temporary difficulty in urinating and vasoconstriction. This is defined as the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels and is triggered through the way in which 25I-NBOMe’s target receptor (5ht2a) modulates both vasoconstriction and vasodilation among its many other functions.
Physically speaking, this can become very uncomfortable but can be considered as safe at sensible dosages. The sensation itself can be described as feelings of tightness and mild to distinct stinging sensations within the arms, legs and neck.
Cognitive effects:
The head space of 25I-NBOMe is remarkably light and underwhelming in comparison to classical psychedelics such as LSD, Psilocin and 2C-I.
An extremely unique aspect of this trip is the way in which most people report feeling almost completely sober even throughout visually intense experiences in terms of their cognitive abilities, with no noticeable change in the specific style of their current thought stream.
At other points however, waves of mild to overwhelming cognitive alterations are certainly present. These waves of cognitive alterations become longer and more drawn out proportional to the dosage consumed. They have so far been confirmed to include,
emotional euphoria, introspection, an enhancement of current mind state, an acceleration of thought, an increased connectivity of thought, time dilation, feelings of deja-vu, the removal of our cultural filter, the emancipation of our internal narrative from the limitations of exclusively linguistic content, induced mindfulness, introspection, induced spiritual or religious perspectives, ego suppression, ego loss and ego death.
There are also mild to powerful but inconsistently manifested entactogenic effects for people who try this substance. This results in increased feelings of love and empathy towards friends and partners in way that therapeutically builds relationships and solves interpersonal problems. These effects do not seem to be quite as strong or profound as those found within other entactogens such as MDMA, AMT and 2CB but are still certainly present and very noticeable.
Visual effects:
The visual effects of 25I-NBOMe are extremely diverse and significantly more complex than 2C-I, with a style to them which could be considered to be similar in appearance and behaviour to that of a typical LSD trip.
In terms of visual enhancements, 25I-NBOMe presents a full and complete array of effects with increased visual acuity, enhancement of colours and an increased sense of pattern recognition all displaying themselves in a level of detail on par with any of the classical psychedelics.
As for visual distortions and alterations,
Visual drifting (melting, breathing, warping and flowing) displays a complete smoothness and high level of detail in its appearance that is far beyond the comparatively embarrassing simplicity and low frame rates of equivalent visual effects found under the influence of the close structural relative of this substance known as 2C-I.
Tracers are reported by many to be much more powerful and colourful in proportion to the visual intensity of the trip when compared to substances such as LSD, Psilocin and 2C-I. This stems from the way in which they are capable of reaching opaque level 3 tracers and trails throughout even the lightest of experiences.
Texture repetition is also present alongside this but does not reach the same level of complexity found within classical psychedelics such as LSD and Psilocin.
Colour shifting and depth perception distortions are present but do not seem to differentiate themselves in stylistic appearance from that of any other psychedelics.
Scenery slicing is so far unconfirmed but entirely possible.
The visual geometry that is present throughout this trip is extremely similar in appearance to that of LSD.
As these geometric forms stand for themselves in terms of stylistic appearance they can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colourful in scheme, glossy in colour, sharp around the edges and motly rounded across their corners.
In comparison to other more commonly used psychedelics they can be described as significantly more intricate than the visual geometry found within 2C-I and most of the 2Cx family in general as well as completely on par with LSD, Psilocin and DMT.
In terms of their behaviour, 25I-NBOMe’s psychedelic geometry leads onto level 7A visual geometry with level 7B remaining so far unconfirmed within this substance. They also seem to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelops the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it.
In terms of hallucinatory states with 25I-NBOMe, this substance seems to be extremely lacking in defined imagery, autonomous entity contact, imagined landscapes, concepts and scenarios. However, transformations within the external environment which partially follow the content of your internal narrative are consistently present.
Auditory effects:
The auditory effects of 25I-NBOME are particularly high in comparison to that of LSD, DMT and Psilocin.
They are most commonly manifested in two distinct forms,
The first of these is a loss of audio filtering which is on par with that of any of the classical psychedelics resulting in an extremely sense of music appreciation.
The second of these two effects are auditory hallucinations, these generally regard random audial concepts such as music, voices and sounds throughout the duration of the trip.
To a lesser extent, auditory distortions and thought stream relevant sound effects such as phasers and other noises are also present.
Health effects, addiction potential and tolerance:
25I-NBOMe is a very new substance, and little is known about its pharmacological or behavioural risks. The LD50 is not known. Some deaths have been attributed to 25I-NBOMe overdose caused by improper handling and uneducated use of this substance. Its recent widespread use suggests that death is primarily caused from overdoses and not from ordinary doses, particularly from insufflation.
The fact that 25I-NBOMe is active in the microgram range is likely a contributing factor since this makes measuring doses significantly more difficult.
It’s worth noting that although many 5-HT2A agonists have documented safety, none of these have been full agonists so their safety data can not be applied to 25I-NBOMe.
In terms of its addictive potential, 25I-NBOMe has not been studied formally but due to its immediate tolerance build up which lasts up to 2 - 3 weeks after the experience, it is essentially impossible to use this substance compulsively.
Legal issues:
- 25I-NBOMe is unscheduled under United States federal law. However, it could possibly be considered an analog of 2C-I (a Schedule I controlled substance) under the Federal Analogue Act. In this case, sale or possession of 25I-NBOMe with the intent of human consumption would be illegal.
- Virginia, Louisiana, and Florida have specifically scheduled 25I-NBOMe as a Schedule I controlled substance.
- All NBOMe substituted phenethylamines are controlled in Russia.
Every where else in the world however, 25I-NBOMe is completely unscheduled and freely available to anybody with an internet connection. If you wish to obtain this substance despite the risks involved you can literally type “buy 25I-NBOMe” into google and find several legitimate vendors on the very first page.
Please keep in mind however that 25I-NBOMe is NOT being sold by anybody specifically for the purposes human consumption as this would be genuinely illegal within most if not all countries.
Conclusion:
In conclusion, 25I-NBOMe is an extremely interesting psychedelic but does not quite compare in terms of visual and cognitive depth if you have access to classical psychedelics such as genuine LSD, DMT and Psilocin.
I will not be seeking this substance out again but experimenting with it has certainly been an interesting and enjoyable experience.
Please go ahead and let me know if you agree or disagree with any particular points contained within this article by using the comment system below.
Previously undocumented component : The emancipation of our internal narrative from the limitations of exclusively linguistic content
This article is dedicated to providing a detailed description for one of four previously undocumented cognitive components of the psychedelic experience which I am currently in the process of writing up. I have experienced this component throughout every single one of my countless trips over the past 3 years. Despite this however, it has taken me 2 and half years to develop a vocabulary which was capable of even noticing its presence, several months to formulate a description which could be considered comprehensive in my own eyes and even longer to pin down a suitable title for that which has never before been named.
This specific component is not a high level effect and can generally be felt along side and above level 1 – 3 psychedelic geometry. It is extremely common and could be described as universal, occurring at varying levels under the influence of almost every psychedelic compound known to man.
So far this list confirms through myself and others to include but certainly not remain limited to,
Psilocin, Psilocybin, Psilacetin, Mescaline, DMT, Ayahuasca, LSD, LSA, AMT, Harmine, 2C-B, 2C-E, 2C-I, 2C-P, and 5-MeO-DMT.
The emancipation of our internal narrative from the limitations of exclusively linguistic content can be described as a forced change in perspective which frees the ego’s conscious thought stream from remaining strictly limited to words and labels. This allows it to think not just in descriptions, but directly in the internally stored concepts that lay behind our linguistic and descriptive knowledge base.
In terms of how this feels experientially, it can be described as the sensation of the concepts behind the words of our internal narrative becoming somehow cognitively felt at every point across themselves in a very high level of detail. Along side this they are also perceived through a simultaneous partially to fully animated visual manifestation that differs from that of an ordinary hallucination through the fact that it exclusively occurs within the minds eye, always remaining completely separate from the trippers direct line of sight.
The experience of directly experiencing the internally stored concepts which lay just behind human description results in the perceived ability of being able to clearly feel in a profound and emotionally intuitive format, the precise consequences, limitations and position within this universe of any singular concept. These feelings are consistently interpreted as a “higher level of understanding” which seems to stem from the way in which this perspective reveals human language to be intrinsically self limited. This intrinsic self limitation is shown by integrating previously held knowledge into a persons felt perspective, transcending our intellectually understood knowledge and showing that words can only act as mere shortcuts to the concepts which they exist to describe.
At lower levels, these integrations of previously held knowledge into the trippers felt perspective can be described as thought stream specific. This means that the concepts which are being felt and seen are exclusively relevant to the words which you are currently thinking. These will feel identical in stylistic behavior whether the concept is arrived at by a simple wandering of thoughts or triggered through the experience of a concept or object perceived within the external environment.
Perhaps the most common example of this which those within the psychedelic community could relate to would be the experience of looking at a plant of any sort and internally feeling as well as visually perceiving, everything that you happen to know about photosynthesis and the evolution of plants no matter how vague or abstract this knowledge might be.
At higher levels, these integrations of previously held knowledge into the trippers felt perspective stop being specific to the words contained within your current thought stream and start becoming all encompassing towards every last internally stored piece of knowledge the tripper has ever known.
This leads onto feelings which are consistently interpreted as a new found level of “total and complete understanding” as the consequences, limitations and position within this universe of every single concept which the tripper previously only knew in terms of its description, becomes felt through a very real and undeniable perspective.
Perhaps the most common examples of these which those within the psychedelic community will relate to, that I have experienced myself and observed through others, would be the experience of a total and profound understanding regarding but not limited to, the themes and archetypes listed below.
- General scientific principles.
- Taking care of your personal health.
- Your position within nature and higher systems of order.
- The consequences of your actions and your responsibility towards them.
- Human civilization as the literal cutting edge of physical complexity.
- Living in balance with nature to the best of your abilities.
- The inevitability of death.
- The sheer unlikeliness of personal existence.
It’s through the direct experience of the concepts behind our knowledge that new life changing perspectives are suddenly felt in an obvious way. These new found viewpoints are rarely considered by the tripper to be the creation of a single new idea or creative insight. Instead they are nothing more than the integration of previously held knowledge which was already understood intellectually into a new fou them in an undeniable, clearly understandable and emotionally felt format which lies within a level of detail far beyond normal human language and description.
At lower levels, these integrations of knowledge are felt to be temporary and consistently subside along with the effects of the substance which has been consumed.
At higher levels however, specific or all encompassing pieces of knowledge can become permanently integrated into a trippers felt perspective for weeks, months, years and even a lifetime after the experience itself. If the knowledge integration has been specific it will likely consist of things which have been only recently learnt or discovered in the preceding days or perhaps weeks before the trip.
This component allows psychedelic users to gain access to a profound and very literal expansion of their consciousness, resulting in extremely therapeutic changes in their perception of the world.
It’s worth noting however that many people including myself have reported that they can experience low level versions of this component when simply high on marijuana.
Personal experience has led me to confirm that this state can even be triggered throughout every day life in temporary, thought stream specific forms through mindful meditation sessions. I have yet to write anything regarding my knowledge behind meditation but intend to at some point in the future and will tie the relevant parts of it directly into this component.
If you have had any experience with this component whatsoever please do report this in the comment section below and the drug or mind state which it occurred on. This provides myself and everybody else with extremely valuable data and would be greatly appreciated.