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DOB, broken down and described

image

Dosage:

Threshold : 0.2 mg
Light : 0.2 - 0.75 mg
Common : 0.75 - 1.75 mg
Strong : 1.75 - 2.5 mg
Heavy : 2.5 - 3.5 mg+

Duration:

Total duration : 7 - 17 hours
Onset / Initial effects : 30 - 90 mins
Coming up : 60 - 90 mins
Peak : 3 - 8 hrs
Coming down : 3 - 8 hrs
After effects : 4 - 8 hrs

Dimethoxybromoamphetamine (DOB), also known as Brolamfetamine and Bromo-DMA, is a psychedelic substituted alpha-methylated phenethylamine, a class of compounds commonly known as amphetamines. The phenethylamine equivalent of this substance (lacking the alpha-methyl group) is 2C-B.

This substance has no history of human usage prior to the 1991 publication of its synthesis and pharmacology in the book PiHKAL (Phenethylamines i Have Known And Loved) by Alexander Shulgin. In modern times it is used as a recreational drug and an entheogen, rarely sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors. It was first synthesized by Alexander Shulgin and described in his 1991 book.

In terms of its pharmacology, this substance acts as a selective 5-HT2A, 5-HT2B, and 5-HT2C receptor partial agonist. Its psychedelic effects are thought to be mediated via its actions on the 5-HT2A receptor.

The DOB experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical effects:

The physical effects of DOB can be broken down into six components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Spontaneous tactile sensations - The body high of DOB is manifested as somewhat intense in comparison to most classical psychedelics. The sensation itself can be described as a constantly present yet somewhat mild energetic pins and needles sensation that encompasses a person’s entire body. It is usually static in its position and felt over every square inch of the skin as if it was coming from behind the users body. Occasionally however it manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
  • Stimulation - In terms of its effects on the physical energy levels of the tripper, DOB is usually considered to be extremely stimulating at levels which do not become overwhelming and are encouraged instead of forced. This results in a shakiness and unsteadiness of the hands at high dosages but encourages trippers to move around, run, dance, climb and generally engage in physical activities. The level of stimulation varies between users however with some people reporting it to be somewhat similar to amphetamine in its intensity and others reporting that it is extremely subtle even at higher dosages. In comparison, other more commonly used psychedelics such as psilocin are generally sedating and relaxed.
  • Enhancement of touch - Feelings of enhanced tactile sensation are consistently present at moderate levels throughout most DOB trips.
  • Nausea - Mild to extreme nausea is reported when consumed in moderate to high dosages and either passes once the tripper has vomited or gradually fades by itself as the peak sets in.
  • Vasoconstriction - This effect is usually only present at higher dosages but can be particularly uncomfortable.

Cognitive effects:

The head space of DOB is described by many as one of mental stimulation and a powerful enhancement of a person’s current mental state. Many user report that it may not be as deep as other traditional psychedelics such as LSD or Psilocin and that it is comparatively empty in terms of its insightfulness.

The total sum of these cognitive components regardless of the setting generally includes:

  • Introspection - This component is consistently manifested only in the context of a non-social setting in which the user is alone.
  • Increased empathy, love and sociability - This component is inconsistently manifested only in the context of social settings in which one is within the company of others. These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA and 2C-B but still prove strong enough to provide long lasting therapeutic effects.
  • Acceleration of thought
  • Time distortion
  • Feelings of fascination, importance and awe
  • Conceptual thinking
  • Enhancement of current mind state
  • Ego suppression, loss and death

Visual effects:

Enhancements

DOB presents a full and complete array of possible visual enhancements which generally includes:

  • Increased visual acuity
  • Enhancement of colour
  • Enhanced pattern recognition

Distortions

DOB presents a full and complete array of possible visual distortions which generally includes:

  • Drifting (Melting, Flowing, Breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in their appearance and unrealistic/cartoon-like in style.
  • Tracers
  • After images
  • Texture repetition
  • Colour shifting
  • Scenery slicing

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of LSD, 25I-NBOME or 2C-B than that of Ayahuasca, Psilocin or 2C-E. They can be comprehensively described as unstructured in their organization, algorithmic in geometric style, intricate in complexity, small in size, fast and smooth in motion, colourful in scheme, glossy in colour, sharp in their edges and equally rounded and angular in their corners. They give off a synthetic feel to them that at higher dosages are significantly more likely to result in states of Level 7A visual geometry over Level 7B.

Hallucinatory states

DOB is capable of producing a full range of low and high level hallucinatory states in a fashion that is significantly less consistent and reproducible than that of many other commonly used psychedelics. These effects include:

  • External hallucinations
  • Internal hallucinations - Although DOB is technically capable of producing of hallucinatory states in a fashion that is on par with psilocin or DMT in its vividness and intensity, in comparison, these effects are extremely rare and inconsistent. Whilst traditional psychedelics such as LSA, Ayahuasca and Mescaline will induce internal hallucinations near consistently at level 5 geometry and above, DOB will for most simply go straight into Level 7A visual geometry. This lack of consistently induced hallucinatory breakthroughs means that for most, LSD is simply not as deep of an experience as certain other psychedelics.

Auditory effects:

The auditory effects of DOB are common in their occurrence and exhibit a full range of effects which commonly includes:

  • Enhancements
  • Distortions
  • Hallucinations

Health effects, addiction potential and tolerance:

The toxicity and long term health effects of recreational DOB use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because DOB is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried DOC within the psychedelic community suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly but nothing can be completely guaranteed.

DOB is not physically addictive and many users experience a frequency self-regulating quality to the drug. Tolerance for DOC seems to be very mild and does not build up without repeated use over a short period of time.

Legal Issues:

  • International: DOB is a Schedule I drug under the Convention on Psychotropic Substances.
  • Australia: DOB is schedule II
  • Canada: Listed as a Schedule 1 as it is an analogue of amphetamine.
  • New Zealand: DOB is Schedule I (Class A) in New Zealand. DOB would also qualify as an “Analogue” under New Zealand’s catch-all Analogues section in Schedule 3 / Class C of their drug laws that would make 2C-I, 2C-E, DOI, DOB, ephedrine, and pseudoephedrine Schedule 3 compounds in New Zealand.
  • Poland: DOB is controlled in Poland.
  • UK: DOB is Schedule I/Class A in the U.K., making it illegal to sell, buy, or possess without a license.

Conclusion:

Although DOB could be considered as bland and generic in comparison to DOC and other more traditional psychedelics, it is still a worthwhile experience and perfect for recreational events. This substance can be generally described as a less insightful version of LSD with a longer duration, generic visual and an emptier headspace.

Click here for a more comprehensive breakdown.

25B-NBOMe, broken down and described

image

Dosage:

Threshold : 100 µg
Light : 100 - 300 µg
Common : 350 - 700 µg
Strong : 700 - 1500 µg

Duration:

Total duration : 8 - 10 hrs
Onset / Initial effects : 15 - 60 mins
Coming up : 60 - 120 mins
Peak : 3 - 4 hrs
Coming down : 1 - 2 hrs
After effects : 5 - 24 hrs

25B-NBOMe or 2C-B-NBOMe is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-B.

It has nearly no history of human use prior to 2010 when it first became popular due its ease of purchase from online research chemical vendors.

25B-NBOMe has efficacy at the 5-HT2A receptor where it acts as a potent partial agonist. It was discovered in 2003 by Ralf Heim at the Free University of Berlin, it differs from 2C-B structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group as shown in the image above. This change in structure results in roughly a sixteen fold increase in potency when compared to 2C-B, allowing even the most extreme of dosages to fit in liquid form onto tabs and blotter paper (which people often mistake for LSD).

There are, however, methods of differentiating between LSD and adulterants like 25B-NBOMe with and without test kits.

For example, one of the key differences between 25B-NBOMe and LSD is that this substance is only active when taken through a sublingual or insufflated route. This means that in order to get the full effects, 25B-NBOMe blotter paper must be lightly chewed on within the mouth for 10 - 20 minutes and never immediately swallowed.

Insufflation, however, is not recommended due to the amount of people who have suffered through dangerous and often fatal overdoses due to this route of administration.

The 25B-NBOMe experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical effects:

The physical effects of 25B-NBOMe can be broken down into six components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Sublingual numbing - assuming the substance has been taken sublingually, the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very obvious feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed. This is the key difference when it comes to determining whether your blotter paper contains LSD or one of the NBOMe series.
  • Spontaneous tactile sensations - the body high itself can be described as a generally mild, all-encompassing, soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of euphoria that become longer and more drawn out proportional to the dosage consumed.
  • Decreased bodily weight - in terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness.
  • Stimulation - in terms of its effects on the physical energy levels of the tripper, 25B-NBOMe is usually considered to be energetic and stimulating, but it can be considered less stimulating when compared to 25I-NBOMe. For most people, this substance induces a unique type of physical stimulation which can be described as feeling extremely energetic but in a way which does not force the tripper to move unless they genuinely choose to do so. For others however, the stimulation can be quite uncontrollable, occasionally resulting in bodily shakes and a grinding of the teeth comparable to that of MDMA and traditional stimulants such as amphetamine, but this is manifested much less consistently when compared to 25I-NBOMe
  • Vasoconstriction - it is worth noting that an undetermined percentage of people who experiment with this drug will experience negative physical side effects, such as a temporary difficulty in urinating and vasoconstriction. This is defined as the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels and is triggered through the way in which 25B-NBOMe’s target receptor (5-HT2A) modulates both vasoconstriction and vasodilation among its many other functions.
  • Nausea - as the tripper begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, but passes once this has either happened or the trip begins to fully set in. In comparison to other psychedelics such as psilocin, LSD, 2C-E and 2C-I, this could actually be very considered very mild in its intensity.

Cognitive effects:

The head space of 25B-NBOMe is described by many as remarkably light and underwhelming in comparison to the classical psychedelics. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout low to moderate dosages. At high dosages however, mild to overwhelming cognitive alterations become present.

The most prominent of these cognitive effects generally include:

  • Introspection - this component is consistently manifested only in the context of a non-social setting in which the user is alone.
  • Increased empathy, love and sociability - the entactogenic effects range from mild to powerful, but are inconsistently manifested. entactogenic effects for people who try this substance usually become prominent in the presence of others. These feelings of increased sociability, love and empathy do not seem to be quite as strong or profound as those found within other entactogens (such as MDMA, 2C-B and AMT)
  • Acceleration of thought
  • Time distortion
  • Feelings of fascination, importance and awe
  • Conceptual thinking
  • Connectivity of thought
  • Enhancement of current mind state
  • Removal of cultural filter
  • Ego suppression, loss and death

Visual effects:

Enhancements

25B-NBOMe presents a full and complete array of possible visual enhancements which generally includes:

  • Increased visual acuity
  • Enhancement of colour
  • Enhanced pattern recognition

Distortions

The visual distortions and alterations which are experienced are detailed below:

  • Drifting (Melting, Flowing, Breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in their appearance and unrealistic/cartoon-like in style.
  • Tracers
  • After images
  • Texture repetition
  • Colour shifting
  • Scenery slicing

Geometry

The visual geometry that is present throughout this trip is often described as similar in appearance to that of LSD. They can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colourful in scheme, glossy in colour, sharp around the edges and mostly rounded across their corners. In comparison to other more commonly used psychedelics they can be described as significantly more intricate than the visual geometry found within 2C-I and most of the 2C-x family in general as well as completely on par with LSD, Psilocin and DMT at appropriately high dosages.

In terms of their behaviour, 25B-NBOMe’s geometry leads onto Level 7A visual geometry with Level 7B remaining so far unconfirmed within this substance. They also seem to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelops the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it.

Hallucinatory states

25B-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. However, level 4 hallucinatory breakthroughs are reported but very uncommon and inconsistent in comparison to other more commonly used psychedelics such as psilocin, 2C-E and DMT.

These effects include:

  • External hallucinations
  • Internal hallucinations - this particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.

Auditory effects:

The auditory effects of 25B-NBOMe are common in their occurrence and exhibit a full range of effects which commonly includes:

  • Enhancements
  • Distortions
  • Hallucinations

Health effects, addiction potential and tolerance:

25B-NBOMe is a very new substance and little is known about its pharmacological or behavioural risks. The LD50 is not known. Some deaths have been attributed to 25B-NBOMe overdose caused by improper handling and uneducated use of this substance. Its recent widespread use suggests that death is primarily caused from overdoses and not from ordinary doses, particularly from insufflation.

The fact that 25B-NBOMe is active in the microgram range is likely a contributing factor since this makes measuring doses significantly more difficult. 

In terms of its addictive potential, 25B-NBOMe has not been studied formally but due to its immediate tolerance build up which lasts up to 2 - 3 weeks after the experience, it is essentially impossible to use this substance compulsively.

Legal issues:

  • UK: 25B-NBOMe is under a temporary class drug order, lasting one year from 10th June 2013.
  • Sweden: 25b-NBOMe is classed as schedule I.
  • USA: On Nov 15, 2013, the DEA added 25B-NBOMe to Schedule I using their emergency scheduling powers, making it “temporarily” in Schedule I for 2 years.

Conclusion:

As for the substance itself, 25B-NBOMe  and the NBOMe series as a whole are an extremely interesting set of psychedelics but do not quite compare in terms of hallucinatory and cognitive depth if you have access to classical psychedelics such as genuine LSD, DMT and psilocin.

Please let me know if you agree or disagree with any particular points contained within this article by using the comment system below.

Click here for a more comprehensive article.

2C-I, broken down and described

image

Dosage (oral)
Threshold : 2-5mg
Light : 5-15mg
Common : 10-25mg
Strong : 20-30mg
Heavy : 30+mg

Duration (oral)
Total duration : 5 - 8 hours
Onset : 20 - 90 minutes
Come up : 20 - 30 minutes
Peak : 3 - 7 hours
Come down : 1 - 2 hours
After effects : 2 - 4 hours

2C-I or 2,5-dimethoxy-4-iodophenethylamine is a psychedelic phenethylamine of the 2C-x family. It was first synthesized by Alexander Shulgin. It was described in Shulgin’s 1991 book PiHKAL: A Chemical Love Story. The drug is used recreationally for its psychedelic and entactogenic effects and is sometimes confused for the analog 25I-NBOMe. 2C-I is commonly sold in its hydrochloride salt form, which is a fluffy, sparkling, white powder, which can sometimes be pressed into tablet form. 2C-I has been explored as a potential stimulant nootropic in doses between 1-8mg.

In terms of its chemistry, 2C-I is a substituted phenethylamine with methoxy groups attached carbons R2 and R5 as well as an iodine molecule attached to carbon R4. It is thought to have efficacy at the 5-HT2A receptor as a partial agonist.

The 2C-I experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical effects:

The physical effects of 2C-I can be broken down into five components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Spontaneous tactile sensations - The body high of 2C-I is manifested as one of the most proportionally intense in comparison to almost all of the classical psychedelics. The sensation itself can be described as an intense and slightly uncomfortable energetic pins and needles sensation that constantly encompasses a person’s entire body. It is usually felt over every square inch of the skin but occasionally manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves. Alongside of this, many users commonly report that the body high can be particularly uncomfortable and sometimes accompanied by dysphoric aches and urges to shift the position of one’s body and prolonged tensing of unusual combinations of muscle groups.
  • Euphoria - Feelings of frequent but unpredictable rushes of warm physical euphoria are extremely common and very pleasurable. These move from the top of the head downwards before envoloping ones whole body.
  • Stimulation - In terms of its effects on the physical energy levels of the tripper, 2C-I is usually considered to be very energetic and stimulating in a fashion that is quite comparable to that of MDMA although encouraged instead of forced.
  • Increased bodily control
  • Enhancement of touch
  • Nausea - Mild to extreme nausea is consistently reported when consumed in moderate to high dosages and either passes once the tripper has vomited or gradually fades by itself as the peak sets in.
  • Loss of temperature regulation
  • Head aches - Some users report mild but uncomfortable head pressures which can occasionally intensify during the offset of the experience.

Cognitive effects:

The head space of 2C-I is described by many as one which is relatively normal in its thought processes even at moderate to high dosages. It is often said to lack insight when compared to that of 2C-E, 2C-B and LSD.
The total sum of these cognitive components regardless of the setting generally includes:

  • Increased empathy, love and sociability - This component is consistently manifested only in the context of social settings in which one is within the company of others. These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA and 2C-B but still prove strong enough to provide long lasting therapeutic effects.
  • Time distortion
  • Feelings of fascination, importance and awe
  • Sexual arousal
  • Enhancement of current mind state
  • Ego suppression, loss and death
  • States of unity and interconnectedness

Visual effects:

Enhancements

2C-I presents a full and complete array of possible visual enhancements which generally includes:

  • Increased visual acuity
  • Enhancement of colour
  • Enhanced pattern recognition

Distortions

2C-I presents a full and complete array of possible visual distortions which generally includes:

  • Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as simplistic and bland in detail, slow and smooth but sometimes jittery in motion, static in appearance and unrealistic/cartoon-like in style.
  • Tracers
  • Symmetrical texture repetition - In comparison to other psychedelics such as LSD and 2C-E this particular effect is bland and simplistic.
  • Colour shifting
  • Scenery slicing

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of LSD or 2C-B than that of 2C-E, psilocin, or ayahuasca although it is much more bland and less detailed. They can be comprehensively described as unstructured in their organization, algorithmic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, both soft and sharp in their edges as well as equally rounded and angular in their corners. They seem high in algorithmic visuals such as fractals and at higher dosages are significantly more likely to result in states of Level 7A visual geometry over Level 7B.

Hallucinatory states

Like LSD, while 2C-I is capable of producing a full range of low and high level hallucinatory states, this is extremely rare and inconsistent at higher levels but common at lower and generally includes the following effects:

  • External hallucinations - The experience of effects such as open eye transformations are common within 2C-I but not consistent.
  • Internal hallucinations - Although 2C-I is technically capable producing of hallucinatory states in a fashion that is on par with psilocin or DMT in its vividness and intensity, in comparison, these effects are extremely rare and inconsistent. Whilst traditional psychedelics such as LSA, Ayahuasca and Mescaline will induce internal hallucinations near consistently at level 5 geometry and above, 2C-I hallucinations will not extend beyond imagery and higher dosages will for most will simply go straight into Level 7A visual geometry. This lack of consistently induced hallucinatory breakthroughs means that for most, 2C-I is simply not as deep of an experience as certain other psychedelics.

Auditory effects:

The auditory effects of 2C-I are common in their occurrence and exhibit a full range of effects which commonly include:

  • Enhancements
  • Distortions
  • Hallucinations

Health effects, addiction potential and tolerance:

The toxicity and long term health effects of recreational 2C-I use does not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 2C-I is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried 2C-I within the psychedelic community suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).

There is a short period of tolerance after 2C-I use. Using 2C-I two days in a row is likely to lead to a diminished experience the second day. However, this effect is nearly non-existent when spaced 5-7 days apart.

Legal issues:

  • European Union: In December 2003, the European Council issued a binding order compelling all EU member states to ban 2C-I within three months.
  • Denmark: It is a controlled substance.
  • Germany: It is a controlled substance.
  • Greece: It is a controlled substance.
  • Ireland: The drug is a controlled substance.
  • Italy: It is a controlled substance.
  • Netherlands: It is a controlled substance.
  • Poland: It is a controlled substance.
  • Sweden: Sveriges riksdag added 2C-I to schedule I (“substances, plant materials and fungi which normally do not have medical use”) as narcotics in Sweden as of March 16, 2004. 
  • United Kingdom: It is controlled as a Class A substance.
  • USA: As of July 9, 2012, in the United States, 2C-I is a Schedule I substance under the Synthetic Drug Abuse Prevention Act of 2012, making possession, distribution and manufacture illegal.

Conclusion:

2C-I is a worthwhile experience but is not as deep as other drugs of the same family. It is a substance which works better for some than others. For example, while many find it to be extremely uncomfortable others find it perfect for recreational use in public and social environments. 

This subjective effect breakdown was made in collaboration with PsychonautWiki admin, Oscarette

Click here for a more comprehensive breakdown.

25C-NBOMe, broken down and described

image

Dosage (sublingual)

Threshold : 25-150µg
Light : 150-400µg
Common : 450-600µg
Strong : 700-1200µg

Duration

Total Duration : 4 - 6 hrs
Onset : 15 - 120 mins
Coming Up : 30 - 120 mins
Peak : 2 - 3 hrs
Coming down : 1 - 2 hrs
After effects : 5 - 24 hrs

25C-NBOMe or 2C-C-NBOMe is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-C.

It has nearly no history of human use prior to 2010 when it first became popular due its ease of purchase from online research chemical vendors.

25C-NBOMe was discovered in 2003 by Ralf Heim at the Free University of Berlin, it differs from 2C-C structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group as shown in the image above. This change in structure results in roughly a sixteen fold increase in potency when compared to 2C-C, allowing even the most extreme of dosages to fit in liquid form onto tabs and blotter paper (which people often mistake for LSD).

There are, however, methods of differentiating between LSD and adulterants like 25-C-NBOMe with and without test kits.

For example, one of the key differences between 25C-NBOMe and LSD is that this substance is only active when taken through a sublingual or insufflated route. This means that in order to get the full effects, 25C-NBOMe blotter paper must be lightly chewed on within the mouth for 10 - 20 minutes and never immediately swallowed.

Insufflation, however, is not recommended due to the amount of people who have suffered through dangerous and often fatal overdoses due to this route of administration.

The 25C-NBOMe experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical effects:

The physical effects of 25C-NBOMe can be broken down into six components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Sublingual numbing - assuming the substance has been taken sublingually, the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very obvious feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed. This is the key difference when it comes to determining whether your blotter paper contains LSD or one of the NBOMe series.
  • Spontaneous tactile sensations - the body high itself can be described as a generally mild, all-encompassing, soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of euphoria that become longer and more drawn out proportional to the dosage consumed.
  • Decreased bodily weight - in terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness.
  • Stimulation - in terms of its effects on the physical energy levels of the tripper, 25C-NBOMe is usually considered to be energetic and stimulating, but it can be considered less stimulating when compared to 25I-NBOMe. For most people, this substance induces a unique type of physical stimulation which can be described as feeling extremely energetic but in a way which does not force the tripper to move unless they genuinely choose to do so. For others however, the stimulation can be quite uncontrollable, occasionally resulting in bodily shakes and a grinding of the teeth comparable to that of MDMA and traditional stimulants such as amphetamine, but this is manifested much less consistently when compared to 25I-NBOMe
  • Vasoconstriction - it is worth noting that an undetermined percentage of people who experiment with this drug will experience negative physical side effects, such as a temporary difficulty in urinating and vasoconstriction. This is defined as the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels and is triggered through the way in which 25I-NBOMe’s target receptor (5-HT2A) modulates both vasoconstriction and vasodilation among its many other functions.
  • Nausea - as the tripper begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, but passes once this has either happened or the trip begins to fully set in. In comparison to other psychedelics such as psilocin, LSD, 2C-E and 2C-I, this could actually be very considered very mild in its intensity.

Cognitive effects:

The head space of 25C-NBOMe is described by many as remarkably light and underwhelming in comparison to the classical psychedelics. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout low to moderate dosages. At high dosages, however, mild to overwhelming cognitive alterations become present; this dosage seems to be lower in proportion to physical effects when compared to 25I-NBOMe.
The most prominent of these cognitive effects generally include:

  • Introspection - this component is consistently manifested only in the context of a non-social setting in which the user is alone.
  • Increased empathy, love and sociability - the entactogenic effects range from mild to powerful, but are inconsistently manifested. Entactogenic effects for people who try this substance usually become prominent in the presence of others. These feelings of increased sociability, love and empathy do not seem to be quite as strong or profound as those found within other entactogens (such as MDMA, 2C-B and AMT)
  • Acceleration of thought
  • Time distortion
  • Feelings of fascination, importance and awe
  • Conceptual thinking
  • Connectivity of thought
  • Enhancement of current mind state
  • Removal of cultural filter
  • Ego suppression, loss and death

Visual effects:

Enhancements

25C-NBOMe presents a full and complete array of possible visual enhancements which generally include:

  • Increased visual acuity
  • Enhancement of colours
  • Enhanced pattern recognition

Distortions

The visual distortions and alterations which are experienced are detailed below:

  • Visual drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in their appearance and unrealistic/cartoon like in style.
  • Tracers
  • After images
  • Texture repetition - In comparison to other psychedelics such as LSD or psilocin, this particular visual alteration is significantly more basic and less intricate in style but still distinctively present and seems more intricate in comparison to 25I-NBOMe.

Geometry

The visual geometry that is present throughout this trip is often described as very similar in appearance to that of LSD. They can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colourful in scheme, glossy in colour, sharp around the edges and mostly rounded across their corners. In comparison to other more commonly used psychedelics, they can be described as significantly more intricate than the visual geometry found within 2C-I and most of the 2C-x family in general as well as completely on par with LSD, psilocin and DMT at appropriately high dosages (which seem lower in proportion to the accompanying physical effects when compared to that of 25I-NBOMe).

In terms of their behaviour, 25C-NBOMe’s geometry leads onto Level 7A visual geometry with Level 7B remaining so far unconfirmed within this substance. They also seem to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelops the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it.

Hallucinatory states

25C-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. However, level 4 hallucinatory breakthroughs are reported but very uncommon and inconsistent in comparison to other more commonly used psychedelics such as psilocin, 2C-E and DMT. This can be considered as on par with and identical in behaviour to that of LSD and 25I-NBOMe.
These effects include:

  • External hallucinations
  • Internal hallucinations - this particular effect commonly contains hallucinations within scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.

Auditory effects:

The auditory effects of 25C-NBOMe are common in their occurrence and exhibit a full range of effects which commonly includes:

  • Enhancements
  • Distortions
  • Hallucinations

Health effects, addiction potential and tolerance:

25C-NBOMe is a very new substance and little is known about its pharmacological or behavioural risks. The LD50 is not known. Some deaths have been attributed to 25C-NBOMe overdose caused by improper handling and uneducated use of this substance. Its recent widespread use suggests that death is primarily caused from overdoses and not from ordinary doses, particularly from insufflation.

The fact that 25C-NBOMe is active in the microgram range is likely a contributing factor since this makes measuring doses significantly more difficult. 

It’s worth noting that although many 5-HT2A agonists have documented safety, none of these have been full agonists so their safety data cannot be applied to 25C-NBOMe.

In terms of its addictive potential, 25C-NBOMe has not been studied formally but due to its immediate tolerance build up which lasts up to 2 - 3 weeks after the experience, it is essentially impossible to use this substance compulsively.

Legal Issues:

  • UK: The 25x-NBOMe series is under a temporary class drug order, lasting one year from 10th June 2013.
  • USA: On Nov 15, 2013, the DEA added 25C-NBOMe to Schedule I using their emergency scheduling powers, making it “temporarily” in Schedule I for 2 years

Conclusion:

The subjective effects breakdown contained within this article was written and contributed by the PsychonautWiki admin known as cocoanatta.

As for the substance itself, 25C-NBOMe  and the NBOMe series as a whole are an extremely interesting set of psychedelics but do not quite compare in terms of hallucinatory and cognitive depth if you have access to classical psychedelics such as genuine LSD, DMT and psilocin.

Please let me know if you agree or disagree with any particular points contained within this article by using the comment system below.

Click here for a more comprehensive article.

2C-B, broken down and described

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Dosage (oral)

Threshold : 2-5mg
Light  : 5-15mg
Common : 15-25mg
Strong : 25-40mg
Heavy : 40+mg

Duration (oral)

Onset : 20 - 90 minutes
Come up : 15 - 30 minutes
Peak : 3 - 7 hours
Come down : 1 - 2 hours
After effects : 2 - 4 hours

Dosage (insufflated)

Threshold : ~1mg
Light  : 1 - 5mg
Common : 5-10mg
Strong : 10 - 15mg
Heavy : 15+mg

Warning!!! (2C-B insufflation is extremely painful)

Duration (insufflated)

Onset : 1 - 2 minutes
Come up : 10 - 20 minutes
Peak : 2 - 4 hours
Come down : 1 - 2 hours
After effects : 2 - 4 hours

2C-B (4-bromo-2,5-dimethoxyphenethylamine) is a psychedelic phenethylamine of the 2C-x family. It was first synthesized by Alexander Shulgin in 1974. 

This substance first saw use among the psychiatric community as an aid during therapy. It was considered one of the best drugs for this purpose because of its short duration, relative absence of side effects, and comparably mild nature. 

Like many 2c-x substances, this drug is a highly dose sensitive psychedelic known for its entactogenic effects, bright visuals, and intense body load. This substance is often described by users as feeling half way between LSD and MDMA. Many reports suggest that while 2C-B’s entactogenic effects are less pronounced than MDMA, the visual effects are described as more pronounced and colourful.

The 2C-B experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical Effects:

The physical effects of 2C-B can be broken down into five components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Spontaneous tactile sensations - The body high of 2C-B is not necessarily one of the most intense, but is instead one of the most complex compared to other psychedelics, sharing components of MDMA, 2C-E, and LSD. This is first characterized by an intense soft warm glow that grows over the body and is capable of becoming extremely physically euphoric. This is most similar to MDMA and is consistently manifested throughout the experience. This is contrasted by an intensely pleasurable yet sharp, cold electric tingling sensation which moves up and down the body. This is most similar to LSD and is also consistently manifested throughout the trip. The final physical effect noticed throughout the experience is an intense and slightly uncomfortable, energetic pins and needles sensation that manifests itself in the form of a continuously shifting and tingling sensation that travels up and down the body in spontaneous waves. This is most similar to 2C-E and is not entirely consistent throughout the trip.
  • Stimulation - In terms of its effects on the physical energy levels of the tripper, 2C-B is usually considered to be very energetic and stimulating in a fashion that is quite comparable to that of MDMA.
  • Increased bodily control
  • Enhancement of touch
  • Nausea - Mild to extreme nausea is reported when consumed in moderate to high dosages and either passes once the tripper has vomited or gradually fades by itself as the peak sets in.

Cognitive Effects:

The head space of 2C-B is described by many as one which is both insightful and relatively normal in its thought processes even at moderate to high dosages.

The total sum of these cognitive components regardless of the setting generally includes:

  • Introspection - This component is consistently manifested only in the context of a non-social setting in which the user is alone.
  • Increased empathy, love and sociability - These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA but still prove stronger and more consistent than other psychedelics of any class. This is capable of providing long lasting therapeutic effects.
  • Sexual arousal
  • Acceleration of thought
  • Time distortion
  • Feelings of fascination, importance and awe
  • Conceptual thinking
  • Connectivity of thought
  • Enhancement of current mind state
  • Removal of cultural filter
  • Ego suppression, loss and death

Visual Effects:

Enhancements

2C-B presents a full and complete array of possible visual enhancements which generally include:

  • Increased visual acuity
  • Enhancement of colours
  • Enhanced pattern recognition

Distortions

As for visual distortions and alterations, effects experienced are detailed below:

  • Visual drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance, and unrealistic/ cartoon like in style.
  • Tracers
  • After images
  • Texture repetition
  • Colour shifting
  • Scenery slicing

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of LSD than that of 2C-E, psilocin, or ayahuasca. They can be comprehensively described as unstructured in their organization, algorithmic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, sharp in their edges and angular in their corners. They seem high in algorithmic visuals such as fractals and at higher dosages are significantly more likely to result in states of Level 7A visual geometry over Level 7B.

Hallucinatory States

Like LSD, while 2C-B is capable of producing a full range of low and high level hallucinatory states, this is extremely rare and inconsistent at higher levels but common at lower and generally includes the following effects:

  • External hallucinations
  • Internal hallucinations - Although 2C-B is technically capable producing of hallucinatory states in a fashion that is on par with psilocin or DMT in its vividness and intensity, in comparison, these effects are extremely rare and inconsistent. Whilst traditional psychedelics such as LSA, Ayahuasca and Mescaline will induce internal hallucinations near consistently at level 5 geometry and above, 2C-B will for most go straight into Level 7A visual geometry. This lack of consistently induced hallucinatory breakthroughs means that for most, 2C-B is simply not as deep of an experience as certain other psychedelics.

Auditory Effects:

The auditory effects of 2C-B are more common than some psychedelics in their occurrence and are capable of producing a full range of effects which commonly include:

  • Enhancements
  • Distortions
  • Hallucinations

Physical Health Effects, Potential Addiction and Tolerance:

There is no current data for the lethal dosage of 2C-B, but it is thought to be extremely high. Alexander Shulgin reported in his book PIHKAL that an accidental dosage of 100mg resulted in no physical or psychological damage.

Since the invention of this substance in 1974, not a single person has yet to accidentally or deliberately experience a fatal overdose with this substance. This suggests that 2C-B is very safe but please keep in mind that clinical studies assessing its safety have not been performed in any scientific context.

In terms of its tolerance, 2C-B can be redosed repeatedly with little to no loss in the strength of its subjective effects. This means that is theoretically possible to become addicted to it but thanks to its psychedelic properties users experience a powerful self-regulating quality to this substance.

Legal Issues:

  • Australia: Possession, production, and sale is illegal.
  • Belgium: Possession, production, and sale is illegal.
  • Brazil: Possession, production, and sale is illegal.
  • The EU: 2C-B is a Schedule II drug.
  • Canada: 2C-B is a Schedule III drug.
  • Estonia: 2C-B is a Schedule I drug.
  • Finland: Possession, production, and sale is illegal.
  • Japan: Possession, production, and sale is illegal.
  • The Netherlands: Possession, production, and sale is illegal.
  • Norway: 2C-B is a Schedule II drug.
  • Poland: 2C-B is a Schedule I drug.
  • Russia: Possession, production, and sale is illegal.
  • Spain: 2C-B is a Category 2 drug.
  • Sweden: 2C-B is a Schedule I drug.
  • Switzerland: Possession, production, and sale is illegal.
  • UK: 2C-B is a Class A drug.
  • USA: 2C-B is a Schedule I drug.

Reader submitted trip reports:

Conclusion:

The main bulk of the 2C-B subjective effects breakdown for this particular article was not written by myself but the PsychonautWiki admin known as Cocoanatta. I have tried 2C-B on two separate occasions and can confirm that the descriptions are indeed accurate.

As for the substance itself, 2C-B is an incredibly fun and therapeutically beneficial substance. This makes it extremely useful for both recreational and introspective purposes. It is, in my opinion, the most suitable psychedelic for a beginner in existence due to its clear, euphoric headspace and proportionally mild visual effects in comparison to that of LSD or mushrooms.

Click here for a more comprehensive breakdown.

LSA, broken down and described

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Onset : 30- 180 min
Duration : 4 - 10 hours
Normal After Effects : 2 - 24 hours

Dosage : Differs between Differs between Morning glory seeds & Hawaiian Baby Woodrose seeds.

LSA (also known as Ergine, d-lysergic acid amide, and d-lysergamide) is an alkaloid of the ergoline family that occurs in various species of vines, the morning glory flower and some species of fungi. It is the dominant alkaloid found in the seeds of several varieties of morning glories in concentrations of approximately 10 µg per seed, as well as Hawaiian baby woodrose seeds at a concentration of around 0.13% of dry weight. It has structural similarities to LSD, putting it in the lysergamide family of psychedelics.

A traditional use of morning glory seeds by Mexican Native Americans was first described by Richard Schultes in 1941 in a short report documenting their use going back to Aztec times. Further research was published in 1960, when Don Thomes MacDougall reported that the seeds of morning glory flowers were used as sacraments by certain Zapotecs (sometimes in conjunction with the seeds of Rivea corymbosa, another species of morning glory which has a similar chemical composition, containing lysergol instead of LSA).

LSA was assayed for human activity by Albert Hofmann in self-trials in 1947 (well before it was known to be a natural compound). Intramuscular administration of a 500 microgram dose led to a tired, dreamy state with an inability to maintain clear thoughts. After a short period of sleep, the effects were gone and normal baseline was recovered within five hours. This suggests that the theory of LSA being the main psychedelic compound within morning glory seeds and Hawaiian baby woodrose is debatable as anecdotal reports suggest that the effects of synthetic LSA and iso-LSA are only slightly psychedelic in their effects and may well be triggered by a mixture of various lysergamides instead of one specific compound.

The LSA experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical Effects:

The physical effects of LSA can be broken down into five components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Spontaneous tactile sensations - the body high of LSA can be described as a mild yet pleasurable, soft tingling sensation. This is largely noticed in high doses and is accompanied by strong waves of physical euphoria which are usually manifested spontaneously at different unpredictable points throughout the trip but can also maintain a consistent presence. In either case, they steadily rise with the onset and hit their limit once the peak has been reached.
  • Sedation - in terms of its effects on the physical energy levels of the tripper, LSA tends to be sedating, however, it can be setting dependent. For example, when taken in settings with large amounts of stimulus or during physically strenuous activities such as walking, running, climbing or dancing it is fully capable of becoming stimulating and energetic. In contrast, however, when taken in calm environments such as darkened rooms with comfortable seating it is consistently relaxing, peaceful and quite sedating.
  • Vasoconstriction

Cognitive Effects:

The head space of LSA is described by many as extremely relaxing yet lucid and clear headed in its style when compared to other commonly used psychedelics such as LSD or Psilocin. Although it is primarily sedating, it is accompanied by fast paced bursts of thought.

LSA contains a large number of psychedelic cognitive effects. The most prominent of these typical effects include:

  • Connectivity of thought
  • Introspection
  • Acceleration of thought
  • Enhancement of current mind state
  • Feelings of fascination, importance and awe
  • Conceptual thinking
  • Ego suppression, loss and death
  • Time distortion
  • Direct communication with the subconscious
  • Deja-Vu

Visual Effects:

The visual effects of LSA are mostly present when large doses have been consumed.

Enhancements

LSA presents a full and complete array of possible visual enhancements which generally include:

  • Increased visual acuity
  • Enhancement of colours
  • Enhanced pattern recognition

Distortions

As for visual distortions and alterations, these are significantly more simplistic from that of open eye distortions found with other psychedelics. Effects experienced are detailed below:

  • Visual drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as mild but highly detailed yet cartoon-like in appearance. They are fast yet smooth in motion and fleeting in their permanence. This is an inconsistently manifested effect with some never reporting such distortions.
  • Colour shifting

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT, ayahuasca and 2C-E than LSD or 2C-B. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, zoomed out and small in size, fast and smooth in motion, colourful in scheme, glossy in colour, blurred in their edges and rounded in their corners. They have a much more “natural” feel to them than LSD and at higher dosages are significantly more likely to result in states of Level 7B visual geometry over Level 7A.

Hallucinatory States

LSA produces a full range of high level hallucinatory states in a fashion that is very consistent when taken in large doses. The effects of such states include:

  • External hallucinations - these are extremely common within LSA and partially follow the content of the user’s current thought process.
  • Internal hallucinations - unlike LSD, LSA consistently produces moderate to high level hallucinatory states in high doses. This particular effect can be compared to a lucid dream state and commonly contains hallucinations with plots, settings, autonomous entity contact and scenarios. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively religious, spiritual, mystical or transcendental nature in their overall theme. These hallucinations are complemented by a powerful enhancement of the ability to visualize concepts. This ability eventually becomes so drawn out proportional to dosage that it leads to full blown hallucinatory states that are entirely lucid and for the most part controllable.

Auditory Effects:

The auditory effects of LSA are common in their occurrence and exhibit a full range of effects which commonly include:

  • Enhancements
  • Distortions
  • Hallucinations

Natural Sources:

Morning Glory Seeds

The seeds of many species of morning glory contain lysergamide alkaloids (including the psychedelic known as LSA). The seeds are found in many gardening stores, however, it’s worth noting that the seeds from commercial sources are often coated in some form of pesticide or methylmercury which can result in extreme nausea if ingested. Seeds without these pesticides can be purchased cheaply online and are freely available through search engines such as Google.

When using morning glory seeds, the dosage for oral consumption is generally considered to be:

  • Light : 50 - 100 seeds / 1.5 - 3 g
  • Common : 100 - 250 seeds / 3 - 6 g
  • Strong : 250 - 400 seeds / 6 - 10 g
  • Heavy : 400 + seeds / 10 + g

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 Hawaiian Baby Woodrose Seeds

Hawaiian Baby Woodrose is a perennial climbing vine that is native to the Indian subcontinent and was introduced to numerous areas worldwide including Hawaii, Africa and the Caribbean. Hawaiian Baby Woodrose seeds may be consumed for their various lysergamide alkaloids such as LSA. These seeds are found in many gardening stores, however, the seeds from commercial sources are often coated in some form of pesticide or methylmercury which can result in extreme nausea if ingested. Seeds without these pesticides can be purchased cheaply online and are freely available through search engines such as Google.

When using morning glory seeds, the dosage for oral consumption is generally considered to be:

  • Threshold : 1 - 4 seeds
  • Light : 3 - 6 seeds
  • Common : 5 - 8 seeds
  • Strong : 7 - 12 seeds
  • Heavy : 12 + seeds

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Physical Health Effects, Potential Addiction and Tolerance:

The toxic dosage of LSA is unknown as there has never been a single reported overdose. This suggests that LSA is perfectly safe to simply try on the odd occasion. 

However, LSA should not be used on a frequent basis. When used repeatedly over a short period of time, the vasoconstriction effects build up while the psychoactive effects get weaker. If you’re feeling sore legs, this is a sign of the vasoconstriction effects building up in your body. The legs feel sore because not enough blood is getting to the muscles. Your upper leg muscles are the largest, most energy eating muscles in your body, and they will feel sore if blood flow to them is lowered even a little bit. If you’ve taken HBWR seeds, morning glory seeds, or pure LSA and are experiencing sore legs you need to hold off for a while. Let your body get back to baseline before using them again. This is more important with LSA (HBWR, morning glories, etc.). With LSA, it can take up to 3 days of abstinence to get back to baseline.

It’s important to note that LSA is non-habit-forming and that the desire to use it can actually decrease with use. It is most often self-regulating. You also build an almost immediate tolerance to LSA after ingestion, preventing you from experiencing its full effects more often than every 4-7 days (unless you increase your dose significantly). 

Legal Issues:

  • The consumption of LSA containing materials is prohibited under state legislation in most Australian states. 
  • LSA is not listed in Canada’s Controlled Drugs and Substances act and is therefore not illegal to possess. It is probably illegal to sell for human consumption as a drug, though the plants that contain it are not controlled in Canada. 
  • LSA is not legally classified as a drug, so consumption or possession of LSA or LSA containing-materials is not prohibited. 
  • LSA is controlled in the Netherlands. This makes it illegal to possess, distribute, and produce without a license. 
  • Chemical LSA is controlled as a drug in New Zealand. The plants and seeds of morning glory species are legal to possess, cultivate, buy, and distribute. Seeds are reportedly sprayed and warnings are included on the packets to not consume the seeds.
  • The status of LSA as chemical is unknown, but LSA-containing plants appear to be uncontrolled in Poland.
  • Sweden is planning to control a number of chemicals as of May 1, 2007 including LSA, 2C-T-4, DXM, and DOI. 
  • LSA is a Class A substance within the United Kingdom and categorized as a precursor to LSD (Misuse of Drugs Act 1971).

Preparation Methods:

LSA containing seeds can be prepared in a number of different ways. Click the links below for detailed step by step techniques.

  • Extraction of LSA tincture - This extraction uses household chemicals such as naptha and ethanol to extract the LSA into a pure and nausea free liquid form. It is perfectly safe if performed correctly and can take between a few hours to several days depending on the desired potency.
  • Nausea free LSA extraction with garlic - This extraction uses cold tap water and a refrigerator to extract the LSA from the seeds and into a glass of water. It uses garlic to minimize the nausea and takes at least 4 hours in total.
  • LSA Adducts - This preparation method is not an extraction and merely theoretical but based around well-reasoned chemistry and consistently themed anecdotal reports. It uses common household herbs such as peppermint and cinnamon bark essential oil to convert LSA into other substances with radically altered subjective effects including LSH and CDLSA.

Reader Submitted Trip Report:

In Conclusion:

The entirety of the LSA subjective effects breakdown for this particular article was not written by myself but the PsychonautWiki admin known as Cocoanatta. I have tried LSA myself on numerous occasions and can confirm that this article is indeed accurate. 

As for the substance itself, although LSA is well known across the psychedelic community, this substance has a pretty bad reputation for causing painful states of nausea, vomiting and vasoconstriction despite the fact that this can be greatly reduced depending on the method of preparation. Alongside of this, LSA is also perceived as a substance which only causes very mild visual and cognitive effects in comparison to other more “classical” psychedelics. 

This assumption however is simply untrue. LSA goes just as deep as LSD, mushrooms, ayahuasca or any other psychedelic and you simply need to find the right dosage and extract it correctly. This makes LSA an excellent choice for any psychonaut, especially when considering how cost effective and widely available the natural plant sources are.

Click here for a more comprehensive breakdown.

The launch of a new website

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My previous post specifically announced a period of inactivity due to the claim that “we are slowly putting together our biggest project yet”. Now after 162 individual articles and 4 months of extremely time consuming work I am excited to announce the launch of an entirely new, fully functional and community driven website under the domain name of www.encyclopediapsychonautica.org

Since the very beginning, as this website has gradually progressed I have become increasingly aware that a tumblr blog is simply too self limiting of a host for a project of this size. Encyclopedia Psychonautica has therefore been created to serve as a wider reaching, legitimate version of disregardeverythingisay and the format of an open community driven wiki has been chosen so that the project can progress as quickly as possible and potentially become entirely self sufficient in its own momentum. 

The website itself is still very much in progress but ultimately exists for the purpose of attempting to establish psychonautics as a legitimate field of science and to reach an understanding of the hallucinogenic experience through a formal documentation and analysis of the consistent subjective effects found within it. We have done this through the act of producing an extremely organized phenomenological breakdown and description of the individual effects and experiences found within a wide variety of differing methodologies in an extremely high level of detail. This has been done from a purely rational perspective which defines its own formalized procedure in a manner which does not depend on analogy, metaphors or mysticism to convey its definitions. 

In a fashion that is similar to what I have been doing with DEIS for the past two years but with a more detailed, consistent and formalised writing style, the effects themselves are documented, organized and mapped out through the use of formal literary descriptions, terminologies and definitions which are organized into the separate articles below,

Along side of these literary descriptions, relevant galleries of image examples are used where ever possible to further reproduce and convey specific categorized subjective effects. We have done this through the act of collecting and creating many image examples which have been catalogued and organized into the extensive hallucinogenic replication gallery which can be found here. This page serves the useful purpose of formally documenting experiences in a level of detail which descriptive language and written analysis could not possibly come close to by itself.

The information contained within the links above have then been used as standardized reference points for the ongoing project of documenting and describing the subjective effects of specific substances and hallucinogens within this extensive index here. This catalogue of specific substances currently documents 23 individual hallucinogens and includes a range of substances, plants and combinations which are organized into appropriate pharmacological and experiential categories. For this specific section of the website we have put careful consideration into providing accurate and comprehensive sets of information on not just the subjective effects but on the chemistry, pharmacology, studied therapeutic uses, lethal dosage, addiction potential, tolerance build up and legal issues with which the substance is associated with. This ensures that users can be fully informed in a way that intends to minimize danger, maximize safety and end the cultural taboos associated with personal hallucinogen usage by providing unbiased and scientifically accurate information.

In order to provide the information necessary to understand the basic physical processes involved within the consumption of these specific substances, we have included a comprehensive and relevant set of encyclopaedic pages which break down and describe the various methods of drug action, neurotransmitters, hormones, pharmacological classes and general neuroscience. These pages can be found within this index here and have been carefully written in a way that is both easy to understand for a novice whilst simultaneously remaining detailed and informative. 

In addition to breaking down the subjective effects and physical neurological processes behind various specific substances we have also provided sets of instructional information regarding a large host of recipes, chemical extraction methods and growing techniques for the preparation of different hallucinogens. This can be found within our hallucinogen preparation section here and currently includes multiple DMT and LSA extractions along side of changa and ayahuasca recipes which are written in clear, easy to understand step by step instructions. This section will be expanded over the upcoming weeks to include a wider array of preparation methods and serves the purpose of making hallucinogens significantly easier to obtain and more accessible to the masses.

As an experiment which eventually hopes to draw genuine statistical data from user submitted experiences we have included a section dedicated to cataloguing a database of user submitted trip reports which provides a detailed and formal analysis in the form of a tagging system below each individual experience. This serves the purpose of providing the community with a greater understanding of its own personal experiences and allows us to confirm the presence of individual subjective effects within specific substances. At the present moment this database of experiences includes 40 individual experiences and can be found here.

The biggest and most exciting difference between DEIS and EP stems entirely from the way in which anybody can now easily contribute their own personal sets of knowledge, ideas, expertise and experiences to this newly emerging field of formalized psychonautics. The prospect of community collaboration and drawing data from the psychedelic community as a whole has been without a doubt, the biggest source of personal motivation for setting up a project of this scale. There are many ways in which others can help and these include,

  • Submitting trip reports.
  • Writing up breakdowns and descriptions of currently undocumented specific substances.
  • Submitting extractions, recipes, growing techniques and preparation methods.
  • Submitting collected or original hallucinogenic replications in the form of images, video or even audio.
  • Submitting currently undocumented subjective hallucinogenic effects.
  • Writing up new articles.
  • Expanding upon and editing old articles.
  • Following the community to-do list which can be found here.
  • Bitcoin donations (1t5frxXujGz1reHrzNaAq4X3vrNM4c2NL) - any and all donations are greatly appreciated and go directly towards the financial upkeep of server maintenance, producing content and furthering the cause.

If you want to contribute but are unfamiliar with standard wiki formatting or do not feel that you possess the literary capabilities to develop your ideas or information in a comprehensive and legitimate manner, we have provided submission alternatives aside from writing the article up yourself. These include submitting your ideas and content to our community discussion subreddit found here, posting to the inbuilt discussion sections found within every article, talking with us in our live IRC chat room found here or simply emailing us at encyclopediapsychonautica@gmail.com. We strongly encourage you to contribute and even the smallest of submissions are sincerely appreciated. If we as a currently disorganized community of people are ever going to make a difference in terms of finally allowing humanity to benefit from what the hallucinogenic experience has to offer then we need to start collectively organizing and collaborating on a level which until this point, has been completely unheard of.

In terms of the short and long term future of both DEIS and EP, I have a huge multitude of elaborate yet necessary plans and general content that will need to be completed in order to progress the field of formalized psychonautics deeper into scientific legitimacy. For example, the creation of an automated piece of software which can generate accurate and statistical descriptions of any hallucinogen through the use of a complex questionnaire system will eventually be integrated into the website and has already been created in the form a manually operated prototype. Along side of this, I have plans for entirely new sections based on meditation and lucid dreaming as well as over 10 individual prewritten articles that will need to be posted to DEIS over the upcoming weeks. I am feeling more motivated and dedicated to this cause than ever before and strongly feel that we are stumbling upon a discovery of genuine historical significance and overwhelmingly profound implications. 

Just to let you know, today is the 2nd year anniversary of DEIS. Thank you for reading and thank you for your support. I am extremely excited to work with all of you in the future and can say with confidence that this is only just the beginning of our projects potential.

Special Announcement ! - Just to let everybody know, I’m going to be fairly inactive for the next few weeks. This is because we are slowly putting together our biggest project yet. I am overwhelmed with work but extremely excited. In the mean time please enjoy this picture that I made today. That is all. <3
EDIT : It’s coming soon, best prepare yourself lol

Special Announcement ! - Just to let everybody know, I’m going to be fairly inactive for the next few weeks. This is because we are slowly putting together our biggest project yet. I am overwhelmed with work but extremely excited.

In the mean time please enjoy this picture that I made today. That is all. <3

EDIT : It’s coming soon, best prepare yourself lol

Ketamine, broken down and described

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Dosage (insufflated)
Threshold : 10 - 15 mg
Light : 15 - 30 mg
Common : 30 - 75 mg
Strong : 60 - 125 mg
The K Hole : 100 - 250 mg

Duration (insufflated)
Onset : 5 - 15 minutes
Duration : 45 - 60 minutes
Normal After Effects : 1 - 3 hours

Dosage (oral)
Threshold : 40 - 50 mg
Light : 50 - 100 mg
Common : 75 - 300 mg
Strong : 200 - 450 mg
The K Hole : 500 + mg

Onset : 5 - 20 minutes (depending on stomach contents)
Duration : 90 minutes
Normal After Effects : 4 - 8 hours

Ketamine is a hallucinogenic drug used in human and veterinary medicine primarily for the induction and maintenance of general anesthesia and usually in combination with a sedative. Other uses include sedation and anestheticin intensive care, (particularly in emergency medicine) and treatment of bronchospasm (a sudden constriction of the muscles in the walls of the lungs bronchioles).

Ketamine was originally developed as a medicine in 1965 as a derivative of phencyclidine (PCP) which was synthesized in 1926. It became popular among recreational users in the 1970s yet remains a ‘core’ medicine in the World Health Organization’s “Essential Drugs List”, a list of minimum medical needs for a basic healthcare system.

This substance is a dissociative which falls into the arylcyclohexylamine class of chemicals and possesses NMDA receptor antagonist properties. NMDA receptors allow for electrical signals to pass between neurones in the brain and spinal column. For the signals to pass, the receptor must be open. NMDA receptor antagonists close the NMDA receptors by blocking them. This disconnection of neurones leads to loss of feeling, difficulty moving, and eventually the famous “k-hole”. 

This drug is the most famous of the classical dissociative hallucinogens. The ketamine experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical effects:

Assuming the substance has been insufflated, the very first physical effect that is noticed is a sharp but relatively painless sensation within the nostril. An unpleasant taste is present for 15 - 20 minutes after insufflation and seems to come and go in an unpredictable manner.
The subjective physical effects of Ketamine however can be broken down into eight components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Disconnection from tactile input
  • Spontaneous tactile sensations - the ketamine body high is a sharp, pleasurable tingling sensation which is location specific to the hands, feet and head.
  • Suppression of touch - this partially to entirely suppresses one’s own sense of touch, creating feelings of numbness within the extremities. It is responsible for the anaesthetic properties of this substance.
  • Physical autonomy
  • Loss of motor control - a loss of gross and fine motor control alongside of balance and coordination is prevalent within nitrous and becomes especially strong at higher dosages. This means that one should be sitting down before the onset unless they are experienced in case of falling over and injuring oneself.
  • Euphoria - this results in feelings of physical euphoria which range between mild pleasure to powerfully all encompassing bliss.
  • Decreased bodily weight - this creates the sensation that the body is floating and has become entirely weightless. This effect is strangely stimulating and encourages physical activities at low - moderate dosages by making the body feel light and effortless to move.
  • Dizziness - although uncommon, some people report dizziness under the influence of ketamine.
  • Nausea - it’s worth noting that high dose ketamine trips can sometimes result in nausea and vomiting at the peak of trip. For most people, this is surprisingly not as unpleasant as they would initially expect due to the accompanying detachment from the physical senses.

Cognitive effects:

The head space of ketamine is often described as particularly forceful towards introspectiion, and gives more analytical thought process when compared to that of DXM and MXE. The cognitive effects of ketamine can be broken down into 9 separate subcomponents which are listed and described below:

  • Disconnection from consciousness
  • Ego suppression, loss and death
  • Time distortion
  • Introspection
  • Deja-Vu
  • Removal of cultural filter
  • Conceptual thinking
  • Direct communication with the subconscious
  • States of unity and interconnectedness

It has been also shown that ketamine, even if taken in small doses, is very effective for patients suffering from chronic depression and bipolar disorder. Studies have shown[8][9] that the effect of the drug is immediate or within 2 hours and consistent in relieving patient’s depressive and/or suicidal symptoms, lasting up to 3 days after a single dosage. In comparison, common antidepressents, such as Prozac, are entirely ineffective for 40% of the population and can take weeks to show effects. This gives ketamine the potential to become an indispensable tool in the treatment of depression and bipolar, which is currently being held back by institutionalised drug prohibition.

The mechanism behind this has been shown by studies[10] to stem from the way in which ketamine triggers the release of glutamate, which is a neurotransmitter that immediately stimulates the growth of damaged synapses which have been damaged by stress and depression.

Visual effects:

Suppression

This substance does not enhance visual stimuli and instead tends to degrade and decrease visual aptitude in a variety of ways which generally include:

  • Disconnection from visual input - this eventually results in the experience of the famous “K-hole” or more specifically, holes, space and voids alongside of structures.
  • Decreased visual acuity
  • Double vision - this component is prevalent at moderate - heavy dosages and makes reading inpossible unless one closes an eye.
  • Suppression of pattern recognition - this effect generally occurs at higher dosages and makes one unable to recognize and interpret perceivable visual data.

Distortions

Ketamine exhibits a full array of dissociative distortions and alterations in visual perception which generally include:

  • Perspective distortions
  • Environmental Cubism
  • Environmental Orbism
  • Scenery slicing

Geometry

The visual geometry found within ketamine can be described as intricate in complexity, fast in movement, soft in edges, rounded and angular in corners, large in size, immersive in presence and very brightly coloured in scheme when compared to that of MXE.

Hallucinatory states

At high dosages Ketamine can produce a full range of high level hallucinatory states in a fashion that that is less consistent and reproducible than that of many other commonly used psychedelic. These effects include:

  • Internal hallucinations - These hallucinatory states can be described as containing plots, settings, autonomous entity contact and scenarios. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability and fixed in style. They can include both new experiences and memory replays which are capable of being weeks in length and real time in experience.
  • External hallucinations

Auditory effects:

The auditory effects of ketamine are common in their occurrence and exhibit a range of effects which commonly include:

  • Auditory suppression
  • Auditory distortions
  • Auditory hallucinations
  • Changes in noise volume

Health effects, addiction potential and tolerance:

There are multiple dangers associated with compulsive ketamine abuse. It is because of this that I highly recommend doing as much research as you possibly can before considering trying this drug.

Extreme ketamine use can injure the bladder, causing ulcers (wounds) and fibrosis (stiffening of the bladder walls and shrinkage). This is strictly associated with regular overuse of ketamine and results in urinary frequency, urgency, pressure, pain, incontinence and/or bleeding from the bladder. Users can receive a variety of diagnoses including ulcerative bladder, interstitial cystitis or ketamine cystitis.

Ketamine is also psychologically addictive when used on a regular basis. This can be avoided however by manually limiting your usage and not taking it compulsively.

Fatal ketamine overdoses are particularly rare but not completely unheard of. The LD50 for ketamine when injected into mice is 400mg/kg. As humans are generally more sensitive to drugs, we divide it by 2, making 200mg/kg the estimated human lethal dose. Assuming the human weighs a conservative 50kg, this would require the lethal dosage to be at least 10 grams. This is 40 times the amount of 250mg necessary for a high dose K-hole experience.

In terms of ketamine tolerance, it can take weeks to build up for some but for others it can take a single night of heavy use. Once a physical tolerance to ketamine has set itself in, it can often take a month or more to reset itself.

Legal issues:

  • The increase in illicit use prompted ketamine’s placement in Schedule III of the United States Controlled Substance Act in August 1999.
  • In the United Kingdom, it was labeled a Class C drug on 1 January 2006.
  • In Canada, ketamine is classified as a Schedule I narcotic as of August 2005.
  • In Hong Kong, as of 2000, ketamine is regulated under Schedule 1 of Hong Kong Chapter 134 Dangerous Drugs Ordinance. It can only be used legally by health professionals, for university research purposes, or with a physician’s prescription.
  • By 2002, ketamine was classified as schedule III in Taiwan.

Conclusion:

Ketamine and dissociatives in general are a truly fascinating experience which open up a whole new world completely unlike anything found with the world of psychedelics. However, they are not nearly as insightful and something which I only try on a very rare basis due to their addictive potential and adverse health effects.

Click here for a more comprehensive breakdown.

A Comprehensive Analysis of Hallucinogen Induced States of Unity and Interconnectedness

I am writing this article to serve as a dedicated analysis and description regarding my current understanding towards what I consider to be the most profound and important freestanding component within the entirety of the hallucinogenic experience. In the past, I have already written about the experience of states of unity and interconnectedness within this article here. This piece of writing however makes the incorrect assumption that this state is exclusively associated with level 7B visual geometry. It was also written from a perspective which is extremely limited in comparison to the understanding which I have since built up over the past few months. However, it is extremely important for me to make it clear that I have not come even remotely close to fully grasping or even comprehending both the logic behind this experience and its many potential consequences.
This is a level of understanding which I do not expect to ever reach. Despite this however, I am determined to steadily progress what I have already learnt through a combination of constant analysis and in-depth discussions with an increasingly large amount of people who have undergone this component.

To begin with, I will describe the specific subjective experience and consistent effects of this component in as much detail as possible.
It starts with a change in perspective which is consistently interpreted as the lifting of a deeply embedded and all encompassing illusion. The destruction of this leads onto feelings that the tripper has undergone some sort of profound “awakening” or “enlightenment”.
This illusion feels as though it has always been in place, forcing a person’s perspective of the world into feeling as if their concept of “self” or “I” with which they identify themselves as, is assumed to intrinsically follow two fundamental rules. The first of these rules is that the self is inherently separate from the external environment and could not possibly extend into it. The second is that the self is specifically limited to not even the physical body as a whole, but exclusively a person’s ego or internal narrative and the image of their own personality as built up through social interactions with other people.
Once removed, the absence of this inbuilt illusion can lead onto two possible levels of cognitive intensities which both follow very consistent and interlocking themes.

The lower and more basic of these two levels can be referred to as external environment specific states of unity and interconnectedness. It can be described as a loss of perceived boundaries between the physical body and either the entirety of the external environment or specific things contained within it. This is felt to be the result of a person’s central sense of self becoming attributed to not just the internal narrative of the ego but in equal measure, to the human body in its entirety and the things around it which it is physically connected to through the senses. This creates the undeniable perspective that the external environment is no longer a separate world which the “I” is confronting and disconnected from, but a single unified system of behaviour. This experience provides the perspective that you are the external environment experiencing itself through the specific point within it that this body’s physical sensory awareness and conscious thought happens to reside in. This sensation is generally described by most people as “becoming one with the things around me”.
The most common and relatable examples of states of unity and interconnectedness, which are manifested as specific to the external environment, include but are certainly not limited to the following perspectives:

  • Becoming one with a specific object which you are interacting with.
  • Becoming one with a specific person which you interacting with.
    (particularly common if engaging in sexual activities)
  • Becoming one with large crowds of people.
    (particularly common at raves and music festivals)
  • Becoming one with immediately perceivable nature but not man kind.
  • Becoming one with the immediate external environment as a whole.

The second and highest level of intensity for this component can be referred to as all encompassing states of unity and interconnectedness. It is at this point of intensity when the experience become infinitely more profound and limitless in its effects.
Once this level is reached, the external systems which a person’s central sense of self has become attributed to and one with is no longer limited to the immediately perceivable environment. Instead, it envelops and becomes attributed to the entirety of a person’s internally stored model of reality, existence and the universe as a whole.

This creates the sudden undeniable perspective that you are literally the entire universe experiencing itself, exploring itself and performing actions onto itself through the very specific point of space and time which your ego and conscious perception happens to reside in.
This is a feeling that when experienced, is immediately and universally understood to be an undeniable truth by anybody who undergoes it. It results in a number of profound consequences and changes in worldview or philosophical perspective which seem to follow fairly consistent themes across almost all people who experience this component. These include but are certainly not limited to:

  • A new system of ethics which values the well being of the external as on par with the importance of the ego.
  • The sensation that talking to others is the experience of engaging with another part of yourself.
  • The sensation that the act of learning is the universe discovering itself and so extremely important this it is accompanied by pleasurable full body mind orgasms and frissons.
  • The immediate interpretation of music, films and art as messages which are sent to you through the universe as a whole.
  • A perspective which feels personally responsible for the entirety of histories human suffering, as well as every single human act of love and technological achievement which our species has committed onto itself.
  • The obviousness of monogamy as a culturally bound tradition which stems from a combination of the ego’s sense of separateness from others and its deep psychological insecurities.
  • A perspective which feels as if death can finally be accepted. This is because it is no longer felt to be the destruction of the self but simply the end of this specific point of conscious awareness which will continue to live on through everything else which it resides in.

This is a component which can either be felt as a temporary sensation that disappears as the tripper sobers up or it can become integrated into a new perspective of the world for weeks, months or years after the experience itself.

It is seemingly completely spontaneous in its rate of occurrence but seems to be particularly common during states of level 7B visual geometry when the tripper is by themselves. It also seems to occur when deep introspection results in the tripper truly resolving and coming to terms with each of their specific sets of insecurities in a way that has allowed them to become finally acceptant and content with who they are as a person.

In terms of the specific substances which are capable of inducing this component, the list currently confirms that it is possible within,

Psilocin, 4-AcO-DMT, DMT, LSD, MDMA, Ketamine, DXM and Salvia divinorum.

Similar notions of unity and the illusory nature of the self seem to be discussed heavily throughout a huge variety of religious, philosophical and psychological sources, which have been produced across both modern and ancient human history. Each of these exist independently from the experience of hallucinogenic substances. I have done my best to collect and list all of these below:

  • The Buddhist phrase of anatta, which can be read about in detail here, specifically refers to the concept of “no-self”. This is the teaching that all things perceived by the senses (including the mental sense of thought) are not really “I” or “mine”, and for this reason one should not cling to them.
  • Monism which can be read about in detail here, is a philosophical position which argues that there is only one thing, which all things are not separate from but working together within as a unified system of behaviour.
  • The Hindu philosophy known as Nondualism can be read about in detail here. This is an idea which states that there is no difference between the concept of Brahman (the external environment) and Ātman (the self).
  • The formally defined world view known as Interconnectedness, which can be read about in detail here, defines itself as the idea that all things are of a single underlying substance and reality, and that there is no true separation deeper than appearances.
  • In psychology, egolessness, which can be read about in detail here, is an emotional state where one feels no ego (or self); of having no distinct being apart from the world around oneself. This is often described as feelings of oneness and being inextricably woven to the fabric of one’s surroundings or environment.
  • In Freudian psychology, oceanic feeling which can be read about in detail here, is described as a sensation of an indissoluble bond, as of being connected with the external world in its integral form which is considered to be the source of religious energy. From this perspective, the feeling is referred to as an entirely subjective fact and is not an article of faith.
  • The overview effect, which is described in detail within this documentary here, is a documented change in perspective experienced by astronauts who see the earth from above. It is described as perceiving the earth as a single unified system with which we are all a part of.
  • Alan Watts, a famous philosopher spoke extensively about the illusory nature of the self. His lectures are extremely informative and can be found in full through torrents on the pirate bay and in parts within many videos across Youtube. His book “The book on the taboo of knowing who you are” is dedicated to a formal explanation of the philosophies and logic behind this perspective and can be found within the form of a free PDF here.

My personal interpretation or description of the themes within these philosophies (which may well be overly simplified or completely wrong) is that the individual and the universe cannot be logically defined as separate systems. This is because, to define a physical object of any sort in even the most basic level of detail, you must also provide an account of the way in which it physically interacts with and is completely dependent on its particular external environment. In turn, the external environment which the original object resides within cannot be fully defined without taking into account the surrounding systems which it is also contained within and so on outwards to encompass existence as a whole. This renders the self or any individual concept as something which can not logically be defined as a contained and separate system from the rest of the universe.
In the very same way that you cannot logically have up without down, left without right, something without nothing, light without dark or positive without negative. You cannot have self without other or each without all because the two concepts inter-depend and exclusively exist in an inseparable and unified relationship to each other.
This suggests to me that one is permitted to use terms such as “I”, “you”, and so on, not because they refer to an empirical and separate self, but simply because they are convenient linguistic tools for use in conversation which should not be considered as anything more than a symbolic approximation or measurement. 
 
Regardless of the legitimacy of these theistic and philosophical perspectives which may be inherently delusional or false, feelings of becoming “one with universe” which are pervasive within human culture, is undoubtedly one of the most profoundly positive changes in perspective that a human being could possibly go through.
Assuming however that this is a rational and logically sound perspective, I am left with two alternate hypotheses in regards to why this illusion seems to be so deeply embedded into each and everyone of us.
The first of these is that it perhaps this illusion formed because it is an evolutionary advantage for the ego to feel intrinsically separate from and more significant than, the external environment as a means of ensuring the motivation for survival. This was my previous theory but upon further analysis has proven implausible. I do not see any physical route through which a drug that simply activates or deactivates receptors could change something that is hard wired into the very structure of the brain.
The second of these personal hypotheses is that the illusion of separateness does not stem from a hardware problem but a software problem. I personally believe that unity may well be the default evolutionary perspective through which human beings originally operated, but it has been suppressed through a purely cultural or more specifically, linguistic problem. This could potentially stem from the way that despite the many obvious benefits of language, it pays a price through completely reorganizing our perception of the world into a system of intrinsically separate labels that in reality, are merely glimpses of a unified whole. It’s an overcoming of this deeply embedded illusion that hallucinogens could theoretically rise above through the way in which they forcibly induce embedded and otherwise hidden states of mind that exist within the subconscious.

If myself and the psychedelic community as a whole dedicate themselves to coming to a total understanding of this important component, the potential consequences could have historical significance. Were the subtle environmental triggers to be accurately determined, it would be theoretically possible to consistently induce permanent and all encompassing states of unity and interconnectedness in a clinical setting. This would provide the entirety of the human species to a total freedom from our psychological, unnecessary and purely ego driven suffering which consumes our entire perspective of the world.

If you have had any experience with this component whatsoever please do report this in the comment section below and the drug which it occurred on. This provides myself and everybody else with extremely valuable data and would be greatly appreciated.  

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