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5-MeO-DMT, broken down and described

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Dosage (smoked)
Threshold : 1 - 2 mg
Light : 2 - 5 mg
Common : 5 - 10 mg
Strong : 10 - 20 mg
Heavy : 20mg +

Duration (smoked)
Total duration : 30 minutes
Onset  : 0 - 1 mins
Peak : 1 - 15 minutes
Come down : 3 - 5 mins
After effects : 15 - 60 mins

Dosage (insufflated)
Threshold : 3 - 5 mg
Light : 5 - 10 mg
Common : 8 - 15 mg
Strong : 10 - 25 mg
Heavy : 25mg+

Duration (insufflated)
Total duration : 2 - 3 hours
Onset : 1 - 10 mins
Peak : 30 - 60 mins
Come down : 30 - 60 mins
After effects : 1 - 3 hrs

5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine) is a powerful psychedelic tryptamine. It is found in a wide variety of plant species, and a single psychoactive toad species. Like its close relatives DMT and bufotenin (5-HO-DMT), it has been used as an entheogen by South American shamans for thousands of years. In modern times, however, it is primarily acquired in its pure form through the use of online research chemical vendors.

When used as a drug in its purified form, 5-MeO-DMT is vaporized, insufflated, or injected and is active at a dose of as little as 2 mg. 5-MeO-DMT is active orally when taken with an MAOI, but according to numerous reports this combination is extremely unpleasant and has a strong body load.

In terms of its chemistry, 5-MeO-DMT is made up of a tryptamine backbone, with a methoxy group substituted onto carbon R5 and two methyl groups substituted onto the nitrogen RN1 and RN2. 5-MeO-DMT is a methoxy derivative of DMT. It is also the O-methyl analogue of bufotenin (5-HO-DMT) and occurs in many organisms alongside of this compound.

In terms of its pharmacology, 5-Meo-DMT’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. Specifically, this molecule shows high affinity for the 5-HT2 and 5-HT1A subtypes. Additional mechanisms of action such as reuptake inhibition of neurotransmitters such as serotonin, noradrenaline and dopamine are involved also.This can result in 5-MeO-DMT becoming dangerously toxic when combined with MAOIs, RIMAs, SSRIs stimulants or any substance which acts as a releasing agent or reuptake inhibitor of neurotransmitters.

5-MeO-DMT is O-demethylated by polymorphic cytochrome P450 2D6 (CYP2D6) to an active metabolite, bufotenin.

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical Effects:

The physical effects of 5-MeO-DMT can be broken down into ten components all of which progressively intensify proportional to dosage. In comparison to its often relatively mild accompanying cognitive and visual effects, 5-MeO-DMT seems to have by far the most proportionally intense and overwhelming physical sensations found within the known psychedelic experience. These individual components are complex, overwhelming and equally capable of being interpreted as either extremely pleasurable or uncomfortable.

Cognitive Effects:

The most prominent of 5-MeO-DMT’s cognitive effects generally include:

Visual effects:

The visual effects of 5-MeO-DMT can be broken down into five components all of which progressively intensify proportional to dosage. In comparison to its consistently overwhelming and intense accompanying cognitive and physical effects, 5-MeO-DMT seems to have some of the most proportionally underwhelming visual effects found within the known psychedelic experience.

  • Visual acuity enhancement and Visual acuity suppression - 5-MeO-DMT is equally capable of both decreasing and increasing visual acuity. The outcome of which effect will manifest seems to be chosen almost entirely at random and is largely setting dependent.
  • Colour enhancement
  • Colour shifting
  • Drifting (Morphing, Breathing, Melting, Flowing) - In comparison to other psychedelics, this effect can be described as identical to DMT in its style, highly detailed, slow and smooth in motion and static in appearance.
  • Geometry - The visual geometry that is present throughout this trip does not usually occur and never extends beyond level 7 at its highest state. It is very similar to DMT although significantly smaller in size and more likely to manifest in darkness or without distractions. In terms of appearance, it can be comprehensively described through its variations as intricate in complexity, abstract in form, equally organic and digital in feel, structured in organization, brightly lit, multicoloured in scheme, glossy in shading, equal in sharp and soft edges, small in size, fast in speed, smooth in motion, equal in rounded and angular corners, immersive in depth and consistent in its intensity.

Auditory effects:

The auditory effects of 5-MeO-DMT are common in their occurrence and exhibit a full range of effects which generally include:

Natural sources:

Colorado River toad: The Colorado River toad (Incilius alvarius), also known as the Sonoran Desert toad, is a psychoactive toad found in northern Mexico and the southwestern United States. Its skin and venom contain 5-MeO-DMT and bufotenin.

The toad’s primary defense system are glands that produce a poison that may be potent enough to kill a grown dog. These parotoid glands also produce the 5-MeO-DMT and bufotenin for which the toad is known. Fresh venom can easily be collected from these glands without harm to the toad. To do this, obtain a flat glass plate or any other smooth, nonporous surface of at least 12-inches square and hold the toad in front of the plate (which is fixed in a vertical position). When the desert toad is stroked near the parotid glands in the neck region, there is a squirting out of this venom. When it is allowed to dry on a hard surface it takes on the texture of rubber cement. It contains up to 15% 5-MeO-DMT, as well as N-methyl-5-methoxytryptamine, 5-MeO-NMT and Bufotenine, which have their own entries. In this manner, the venom can be collected on the glass plate, free of dirt and liquid released when the toad is handled.

Physical Health Effects, Potential Addiction and Tolerance:

The toxicity and long term health effects of recreational 5-MeO-DMT use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. Anecdotal evidence from people within the psychedelic community who have tried 5-MeO-DMT suggests that although physically intense, this substance is well tolerated and physically benign just like other tryptamines. There are no known negative health effects attributed to trying this substance at low or heavy dosages and it has a long history of usage dating back thousands of years.

Deaths from 5-MeO-DMT are rare but, as a powerful monoamine reuptake inhibitor, injury can occur when excessive doses are taken or when taken with drugs such as MAOIsRIMAsstimulants and any substance which act as a releasing agent or reuptake inhibitor of neurotransmitters such as serotonin and dopamine. This has resulted in well documented deaths that are easily avoidable and could have been otherwise prevented.

There is a strong tolerance gained after a single dosage of this compound. This diminishes effects greatly if one tries to redose but returns to base line levels within 24 hours.

Legal issues:

  • Denmark: As of December 1, 2004, 5-MeO-DMT was legally restricted to “medical or scientific purposes”.
  • Gemany: As of December 1, 2004, 5-MeO-DMT was legally restricted to “medical or scientific purposes”.
  • Greece: 5-MeO-DMT became a controlled substance in Greece on February 18, 2003 [EU Legal Database].
  • New Zealand: 5-MeO-DMT is Schedule I (Class A) in New Zealand.
  • Sweden: Sveriges riksdags health ministry Statens folkhälsoinstitut classified 5-MeO-DMT as “health hazard” under the act Lagen om förbud mot vissa hälsofarliga varor (translated “Act on the Prohibition of Certain Goods Dangerous to Health”) as of Oct 1, 2004, in their regulation SFS 2004:696 listed as 5-metoxi-N,N-dimetyltryptamin (5-MeO-DMT), making it illegal to sell or possess.
  • Switzerland: 5-MeO-DMT is Schedule I in Switzerland.
  • Romania: 5-MeO-DMT is illegal in Romania since February 2010.
  • USA: 5-MeO-DMT was added to Schedule I, effective January 19, 2011. This means it is illegal to manufacture, buy, possess, or distribute (sell, trade or give) without a DEA license.

Conclusion:

In conclusion, 5-MeO-DMT is an A-Typical psychedelic which although interesting, remains very consistent and repetitive in comparison to other tryptamines such as DMT itself. It is worth trying for the sheer physical intensity and euphoria of it but I would not recommend this substance to anybody who is looking to experience genuine psychedelia.

This substance breakdown was written through collaboration between PsychonautWiki contributors Pjosepherum, Josifikins and Oscarette. The full article is available here.

☯ ♡ ∞ ♡ ☯

Today marks three years since the start of DEIS. We would like to thank each and every one of you for the balls you have tripped, your support and your contributions. Much love to all of you!!! ♡   (• ε •)

Sorry for the lack of new content around here recently, you can be expecting many posts and updates very soon. In the mean time, for frequent updates, an active community and a far superior website, please visit our ongoing project www.PsychonautWiki.org

MDAI, broken down and described

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Dosage (oral):

Threshold : 20 - 30mg
Light : 60 - 100mg
Common : 100 - 175mg
Strong : 175 - 300+mg

Duration (oral):
Onset : 20 - 70 minutes
Peak : 3 - 5 hours
Coming down : 3 - 4 hours
After effects : 24 hours

MDAI (5,6-Methylenedioxy-2-aminoindane) is a drug developed in the 1990s by a team led by David E. Nichols at Purdue University. It acts as a non-neurotoxic and highly selective serotonin releasing agent (SSRA) which produces entactogen effects in humans similar to that of MDMA.

In terms of its chemistry, the chemical structure of MDAI is indirectly derived from that of the illicit drug MDA, but the alpha-methyl group of the alkylamino amphetamine side chain has been bound back to the benzene nucleus to form an indane ring system. This changes its pharmacological properties substantially.

In terms of its pharmacology, MDAI has been shown to inhibit the reuptake of serotonin, dopamine, and norepinephrine. This demonstrates that MDAI has selective affinity for the serotonin receptor. Studies show that the brains of animals treated with MDAI have greater extracellular concentrations of monoamine neural transmitters, most significantly serotonin. This result indicates that MDAI is a potent releaser of serotonin while effectively inhibiting the reuptake of serotonin. For comparison, MDAI is similar in potency with releasing serotonin to MDA but significantly less potent than MDMA.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects may rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical Effects:

The physical effects of MDAI can be broken down into seven components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Euphoria
  • Enhancement of touch
  • Sedation - The biggest difference between MDAI and MDMA is that due to a comparative lack of dopamine reuptake inhibition, MDAI primarily results in moderate sedation and therefore discourages physical activities such as running, dancing or climbing.
  • Spontaneous tactile sensations - The “body high” of MDAI can be described as a moderate to extreme euphoric, soft and warm tingling sensation that encompasses the entire body. It is capable of becoming overwhelmingly pleasurable at higher dosages. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
  • Dehydration - Feelings of dry mouth and dehydration are a universal experience with MDAI; this effect is a product of an increased heart rate and an extreme motivation to engage in strenuous physical activities. While it is important to avoid becoming dehydrated, especially when out dancing in a hot environment, there have been a number of users suffering from water intoxication through over-drinking so it is advised that users simply sip at water and never over-drink.
  • Vibrating vision - At high dosages, a person’s eyeballs may even begin to spontaneously wiggle back and forth in a rapid motion, causing the vision to become blurry and temporarily out of focus— a condition known as nystagmus.

Cognitive Effects:

The cognitive effects of MDAI can be broken down into four components all of which progressively intensify proportional to dosage. The general head space of MDAI is described by many as one of euphoria and feelings of love or empathy. It contains a number of typical entactogenic cognitive effects.

The most prominent of these cognitive effects generally include:

  • Euphoria - Strong emotional euphoria and feelings of happiness are present within MDAI and are a direct result of serotonin and dopamine release.
  • Increased empathy, love and sociability - This particular effect is equally as pronounced, powerful and therapeutic as that of MDMA or 2C-B. It is the most obvious and noticeable effect within any MDAI experience and dominates the head space.
  • Acceleration of thought
  • Mindfulness

Visual effects:

The visual effects of MDAI only occur at higher dosages and are subtly psychedelic. These generally include:

Physical Health Effects, Potential Addiction and Tolerance:

MDAI and other similar drugs have been widely used in scientific research, as they are able to replicate many of the effects of MDMA but without causing the neurotoxicity which may be associated with MDMA and some related drugs. No tests have been performed on cardiovascular toxicity.

There is currently no scientific data on the lethal dosage of MDAI within human beings but it is thought to be high in comparison to its active dosage. Due to its action as a serotonin reuptake inhibitor, overdoses of this substance would likely result in acute or even fatal serotonin syndrome.

The tolerance to MDAI builds up with repeated usage in much the same way that MDMA does. There does not seem to be any addictive potential but long term usage could potentially lead onto it.

Legal issues:

MDAI is currently a legal grey area world wide and freely available through the use of online research chemical vendors. This does not mean that you are guaranteed to be immune from legal prosecution should you be found in possession of this substance as it is likely to vary from country to country.

Conclusion:

In conclusion, MDAI is an extremely interesting alternative to MDMA due to its lack of neurotoxic effects and minimal dopamine reuptake inhibition. I would suggest this compound to anybody who wishes to experience the profound therapeutic entactogenic effects of MDMA without the stimulation or neurotoxicity. I would recommend the use of 5-HTP serotonin supplements the day after heavy MDAI usage to further mitigate its unlikely adverse effects .

This substance breakdown was written through collaboration between PsychonautWiki administrators Josifikins and Oscarette. The full article is available here.

4-AcO-MET, broken down and described

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Dosage (oral):

Threshold : 5 - 10mg
Light : 10 - 20mg
Common : 20 - 30mg
Strong : 30 - 40mg
Heavy : 40mg+

Duration (oral):

Total Duration : 4 - 6 hours
Onset : 20 - 60 minutes
Peak : 1 - 2 hours
Coming down : 2 - 4 hours
After effects : 1 - 5 hours

4-Acetoxy-MET (4-Acetoxy-N-methyl-N-ethyltryptamine, metacetin or 4-AcO-MET) is a psychedelic tryptamine thought to be a serotonergic psychedelic similar to 4-AcO-DMT, LSD and DMT. Its molecular structure and pharmacological effects resemble those of the tryptamine psilocin which is the primary psychoactive chemical in magic mushrooms.

In terms of its chemistry, 4-AcO-MET is the acetate ester of 4-HO-MET. It is a substituted tryptamine with an acetoxy group at the 4 position of the cyclohexane ring, an ethyl chain and a methyl chain on the nitrogen position.

It is hypothesized that this compound is quickly hydrolyzed into the free phenolic 4-HO-MET, although human studies concerning the metabolic fate of this drug are lacking. This would explain a somewhat similar experience in their subjective effects. This is similar to how 4-AcO-DMT is thought to be deacetylated to 4-HO-DMT during first pass metabolism and subsequent passes through the liver.

In terms of its pharmacology, 4-AcO-MET’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

4-AcO-MET is commonly sold as a research chemical through the use of online vendors. In terms of its effects, it can be vaguely described as somewhat more synthetic in feel to that of other tryptamines but with a shorter duration.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical Effects:

The physical effects of 4-AcO-MET can be broken down into three components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Spontaneous tactile sensations - The “body high” of 4-AcO-MET can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
  • Sedation - In terms of its effects on the physical energy levels of the tripper, 4-AcO-MET is considered by most to be relaxing, stoning and mildly sedating. This sense of sedation is often accompanied by compulsive yawning.
  • Nausea

Cognitive Effects:

The cognitive effects of 4-AcO-MET are described by many as somewhat relaxing, yet face-paced in style with similarities to psychedelics such as LSD or 2C-B which tend to be cognitively energetic and stimulating. The drug contains a large number of typical and unique psychedelic cognitive effects.

The most prominent of these typical effects generally include:

Visual effects:

Enhancements

4-AcO-MET presents a full and complete array of possible visual enhancements which generally includes:

Distortions

As for visual distortions and alterations, the effects experienced are detailed below:

Geometry

The visual geometry that is present throughout this trip can be described as somewhat similar in appearance to that of Psilocin, 4-AcO-DMT and 4-HO-MiPT but with far stronger synthetic digital undertones reminiscent of LSD or 2C-B. 4-AcO-MET can be comprehensively described through its variations as intricate in complexity, abstract in form, equally synthetic and organic in style, structured in organization, extremely brightly lit and multicoloured in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, angular in corners, unimmersive in depth and consistent in intensity. The visuals have a contradictory “natural” and “synthetic” feel to them which is reminiscent of both LSD and and Psilocybin. Higher dosages are significantly more likely to result in states of Level 8A visual geometry over Level 8B.

Hallucinatory States

4-AcO-MET and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. These effects generally include:

Auditory Effects:

The auditory effects of 4-AcO-MET are common in their occurrence and exhibit a full range of effects which commonly include:

Physical Health Effects, Potential Addiction and Tolerance:

The toxicity and long term health effects of recreational 4-AcO-MET use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 4-AcO-MET is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried 4-AcO-MET within the psychonaut community suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).

There is no current data for the LD50 of 4-AcO-MET, but it is thought to be high.

4-AcO-MET does not seem to be physically addictive and many users experience a self-regulating quality. There seems to be a tolerance build up when used consecutively multiple days in a row which requires one to double their dosage each time to achieve the same effects.

Legal issues:

USA: 4-Acetoxy-MET is unscheduled in the United States, but the possession and sale of 4-Acetoxy-MET could possibly be prosecuted under the Federal Analog Act if intent to consume can be proven because of its structural similarities to psilocin.

Conclusion:

4-AcO-MET induced a trip which was distinctively different from that of other more commonly used research chemicals that I have tried. The colourful, digital and synthetic geometry was in sharp contrast to that of 4-AcO-DMT, psilocybin and ayahuasca. This combined with its shorter duration and equally insightful headspace made for a therapeutic and recreational experience somewhat halfway between that of mushrooms and LSD.

This substance breakdown was written through collaboration between PsychonautWiki contributors Josifikins and Oscarette. The full article is available here.

AL-LAD, broken down and described

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Dosage (oral):

Threshold : < 20 µg
Light : < 80 µg
Common : 80 - 160 µg
Strong : ~ 300 µg
Heavy : > 300 µg

Duration (oral):

Total Duration : 6 - 9 hours
Onset : 30 - 60 minutes
Peak : 3 - 5 hours
Coming down : 3 - 4 hours
After effects : 2 - 5 hours

6-allyl-6-nor-lysergic acid diethylamide (abbreviated AL-LAD, also known as Aladdin) is a semi-synthetic hallucinogenic psychedelic drug of the lysergamide family, as described by Alexander Shulgin in the book TiHKAL (Tryptamines i Have Known And Loved).

This substance has little to no history of human usage. However, it has recently become commonly marketed along side of LSZ as a legal alternative to LSD through online research chemical vendors.

In terms of its chemistry, the molecule differs in structure to LSD by the simple replacement of the methyl group with an allyl group at the 6th nitrogen. Lysergamides are distinct from both tryptamines and phenethylamines, although the chemical structure is more similar to a tryptamine than a phenethylamine.

In terms of its pharmacology, AL-LAD acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from AL-LAD’s efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

AL-LAD shares many common traits with LSD; it appears to be equal in potency as well as similar in mechanism. However, the progression and duration of effects are compressed due to its metabolic differences.

While the subjective effects are almost identical to that of LSD, AL-LAD is significantly shorter in its duration. In comparison to its structural relative LSZ, it is reported to be more introspective and stoning. It therefore comparatively lies on the opposite end of the spectrum of effects which most lysergamides are capable of producing.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical Effects:

  • Spontaneous tactile sensations - The “body high” of AL-LAD can be described as proportionally intense in comparison to its accompanying visual and cognitive effects. It behaves as a euphoric, fast moving, sharp and location specific tingling sensation. For some it is manifested spontaneously at different unpredictable points throughout the trip, but for most it maintains a steady presence that rises with the onset and hits its limit once the peak has been reached. At moderate to high doses of AL-LAD, this sensation will usually hit its highest level and become so overwhelming that people find themselves writhing on the floor in complete pleasure.
  • Stimulation - In terms of its effects on the physical energy levels of the tripper, AL-LAD is usually considered to be very energetic and stimulating without being forced. For example, when taken in any environment it will usually encourage physical activities such as running, walking, climbing or dancing. In comparison, other more commonly used psychedelics such as psilocin are generally sedating and relaxing.
  • Nausea - Mild nausea is occasionally reported when consumed in moderate to high dosages and either passes instantly once the tripper has vomited or gradually fades by itself as the peak sets in.
  • Enhancement of touch - Feelings of enhanced tactile sensation are consistently present at moderate levels throughout most AL-LAD trips. Once level 8A geometry is reached, an intense sensation of suddenly becoming aware of and being able to feel every single nerve ending across a person’s entire body all at once is consistently present.
  • Increased bodily control

Cognitive Effects:

The cognitive effects of AL-LAD can be broken down into 14 components all of which progressively intensify proportional to dosage. In comparison to other psychedelics such as Psilocin, LSA and Ayahuasca, AL-LAD is significantly more stimulating and fast paced in terms of the specific style of thought stream which it produces and contains a large number of potential effects.

The most prominent of these cognitive effects generally include:

Visual effects:

Enhancements

AL-LAD presents a full and complete array of visual enhancements which generally includes:

Distortions

AL-LAD presents a full and complete array of visual distortions which generally include:

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 2C-B or 2C-I than Psilocin, LSA or DMT. It can be comprehensively described through its variations as primarily intricate in complexity, algorithmic in form, unstructured in organization, brightly lit, colourful in scheme, organic in feel, multicoloured in scheme, flat in shading, soft in its edges, large in size, slow in speed, smooth in motion, round in its corners, unimmersive in depth and consistent in intensity. At higher dosages, it consistently results in states of Level 8A visual geometry over Level 8B.

Hallucinatory States

AL-LAD is capable of producing a full range of low and high level hallucinatory states in a fashion that is significantly less consistent and reproducible than that of many other commonly used psychedelics. These effects include:

  • Transformations
  • Internal hallucinations (Autonomous entities, Settings, sceneries, and landscapes,Alterations in perspective and Scenarios and plots) - Although AL-LAD is technically capable of producing hallucinatory states in a fashion that is on par with psilocin or DMT in its vividness and intensity, these effects are extremely rare and inconsistent in comparison. Whilst traditional psychedelics such as LSA, Ayahuasca and Mescaline will induce internal hallucinations near consistently at level 5 geometry and above, AL-LAD will for most simply go straight into Level 8A visual geometry. This lack of consistently induced hallucinatory breakthroughs means that for most, AL-LAD is simply not as deep of an experience as certain other psychedelics. On the rare occasion that they are induced however, they can be comprehensively described in terms of their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability and geometry-based in appearance.

Auditory Effects:

The auditory effects of AL-LAD are common in their occurrence and exhibit a full range of effects which commonly includes:

Physical Health Effects, Potential Addiction and Tolerance:

The toxicity and long term health effects of recreational AL-LAD use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because AL-LAD is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychedelic community who have tried AL-LAD suggests that there is no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).

AL-LAD is non-habit forming and the desire to use it can actually decrease with use. It is most often self-regulating.

An almost immediate tolerance is built to AL-LAD after ingestion, preventing one from experiencing its full effects more often than every 4-7 days unless they increase their dose significantly.

Legal issues:

AL-LAD is currently a legal research chemical in the UK, however it is illegal in the US under the analogue act when sold for human consumption. It is unclear in many countries whether it is legal or not and one should take precaution and assume it is illegal to avoid legal issues.

On June 10th, 2014 the UK ACMD recommended that AL-LAD be specifically named in the UK Misuse of Drugs Act as a class A drug despite not identifying any harm associated with its use.[2]

Conclusion:

AL-LAD induces a worthwhile lysergamide experience which can be described as almost indistinguishable from that of LSD although with a much shorter duration. It is a trip which is equally compatible for both recreational and spiritual settings. I would recommend this substance to anybody who is interested in experiencing a somewhat legal alternative to LSD.

This substance breakdown was written through collaboration between PsychonautWiki contributors Pjosepherum, Josifikins and Oscarette. The full article is available here.

4-HO-MiPT, broken down and described

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Dosage (oral):

Threshold : 5 - 10mg
Light : 10 - 20mg
Common : 20 - 30mg
Strong : 30 - 40mg
Heavy : 40mg +

Duration (oral):

Total Duration : 6 - 8 hours
Onset : 20 - 60 minutes
Initial effects : 15 - 30 minutes
Peak : 3 - 6 hours
Coming down : 3 - 5 hours
After effects : 2 - 5 hours

4-HO-MiPT (miprocin, 4-hydroxy-N-methyl-N-isopropyltryptamine, or hats) is an synthetic compound and a lesser-known psychedelic tryptamine. It is thought to be a serotonergic psychedelic, similar to 4-AcO-DMT, LSD and DMT. Its molecular structure and pharmacological effects resemble those of the tryptamine psilocin, which is the primary psychoactive chemical in magic mushrooms.

This substance is relatively uncommon and has only a short history of human use. It was presumably first synthesized by Alexander Shulgin. Its synthesis is described in his book TiHKAL along with reports by people who had ingested the compound. Shulgin’s trials and other anecdotal information suggest that 4-HO-MiPT is similar in activity to psilocin.

In terms of its chemistry, 4-HO-MiPT is the 4-hydroxyl analog of the substituted tryptamine known as MiPT (N-methyl-N-isopropyltryptamine) as well as the isopropyl homolog and structural analog of 4-HO-DMT (Psilocin).

In terms of its pharmacology, 4-HO-MiPT’s psychedelic effects are believed to come from its efficacy at the 5-HT 2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical Effects:

  • Spontaneous tactile sensations - The “body high” of 4-HO-MiPT can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
  • Sedation - In terms of its effects on the physical energy levels of the tripper, 4-HO-MiPT is considered by most to be relaxing, stoning and mildly sedating. This sense of sedation is often accompanied by compulsive yawning.
  • Runny nose
  • Watery eyes

Cognitive Effects:

The cognitive effects of 4-HO-MiPT are described by many as extremely relaxing, profound and stoning in style when compared to other commonly used psychedelics such as LSD or 2C-B which tend to be energetic and stimulating. It contains a large number of typical and unique psychedelic cognitive effects.

The most prominent of these typical effects generally include:

Visual effects:

Enhancements

4-HO-MiPT presents a full and complete array of possible visual enhancements which generally includes:

Distortions

As for visual distortions and alterations, effects experienced are detailed below:

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of Psilocin, Ayahuasca and 2C-E than LSD or 2C-B. It can be comprehensively described through its variations as intricate in complexity, abstract in form, organic in style, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, soft in edges, large in size, slow in speed, smooth in motion, rounded in corners, unimmersive in depth and consistent in intensity. The visuals have a very “natural” feel to them and at higher dosages are significantly more likely to result in states of Level 8B visual geometry over Level 8A.

Hallucinatory States

4-HO-MiPT and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. These effects generally include:

Auditory Effects:

The auditory effects of 4-HO-MiPT are common in their occurrence and exhibit a full range of effects which commonly include:

Physical Health Effects, Potential Addiction and Tolerance:

The toxicity and long term health effects of recreational 4-HO-MiPT use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 4-HO-MiPT is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried 4-HO-MiPT within the psychonaut community suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).

There is no current data for the LD50 of 4-HO-MiPT, but it is thought to be high.

4-HO-MiPT does not seem to be physically addictive and many users experience a self-regulating quality. There seems to be a tolerance build up when used consecutively multiple days in a row which requires one to double their dosage each time to achieve the same effects.

Legal issues:

  • Sweden: Sveriges riksdags health ministry Statens folkhälsoinstitut classified 4-HO-MiPT as a “health hazard” under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of November 1, 2005, making it illegal to sell or possess.[1]
  • United Kingdom: The substance could be considered illegal in the UK under the Misuse of Drugs Act of 1971.
  • United States: 4-HO-MiPT is an unscheduled drug in the United States. However, it is an analog of psilocin, which could lead to prosecution under the Federal Analog Act.

Conclusion:

4-HO-MiPT induces a generic yet worthwhile tryptamine experience which can be described as almost indistinguishable from that of psilocybin mushrooms and 4-AcO-DMT. It also has the same dosage range to that of 4-AcO-DMT and I would recommend this substance to anybody who is interested in experiencing psychedelia.

This substance breakdown was written through collaboration between PsychonautWiki contributors Josifikins and Oscarette. The full article is available here.

2C-T-7, broken down and described

image

Dosage (oral)
Threshold : 3 - 5 mg
Light : 10 - 20 mg
Common : 15 - 30 mg
Strong : 10 - 50 mg
Heavy : 25 - 60mg

Duration (oral)
Total duration : 5 - 10 hrs
Onset  : 60 - 90 mins
Come up : 15 - 30 minutes
Peak : 3 - 7 hours
Come down : 1 - 2 hours
After effects : 2 - 4 hours

Dosage (insufflated)
Threshold : 1 - 3 mg
Light : 2 - 10 mg
Common : 5 - 15 mg
Strong : 5 - 20 mg
Heavy : 7 - 25 + mg

Duration (insufflated)
Total duration : 3 - 7 hours
Onset : 5 - 15 mins
Come up : 20 - 60 mins
Peak : 2 - 4 hours
Come down : 1 - 2 hours
After effects : 1 - 2 + hours

2C-T-7 (2,5-dimethoxy-4-propylthiophenethylamine) is a psychedelic phenethylamine of the 2C-x family. It was first synthesized by Alexander Shulgin in his book PiHKAL: A Chemical Love Story. This particular substance is part of the so-called “magical half-dozen” list which refers to Shulgin’s self-rated most important phenethylamine compounds, all of which except mescaline he developed and synthesized himself. They are found within the first book of PIHKAL, and are as follows: Mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7.

In terms of its chemistry, 2C-T-7 is a substituted phenethylamine with methoxy groups attached to carbons R2 and R5as well as a sulfide chain attached to carbon R4.

In terms of its pharmacology, 2C-T-7 has efficacy at the 5-HT2A receptor as a partial agonist. This is a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines. Along side of this, as the 2,5-desmethoxy derivative of 2C-T-7 has been shown to be a moderate monoamine oxidase A inhibitor, this substance may likewise have MAOI effects.

2C-T-7 is a highly dose sensitive psychedelic known for its strong visuals and intense body load. Many reports also indicate that the effects of this chemical may be overly intense for those who are not already experienced with psychedelics. The experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical effects:

The physical effects of 2C-T-7 can be broken down into six components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Spontaneous tactile sensations - The body high of 2C-T-7 is intense but, in comparison to 2C-E or 2C-B, it can be considered mild though is still capable of becoming very powerful and highly physically euphoric. It is similar yet distinct from the body high experienced on 2C-E, 2C-B, and LSD. The sensation itself can be described as intense and will manifest itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
  • Stimulation - In terms of its effects on the physical energy levels of the tripper 2C-T-7 is usually considered to be very energetic and stimulating in a fashion that is quite comparable to that of other phenethylamines such as 2C-B, 2C-E and 2C-P.
  • Increased bodily control - Although this component is capable of manifesting itself in a distinct and noticeable fashion for most users it does not generally seem to be as apparent or intense as the same component found within LSD and 2C-B.
  • Enhancement of touch
  • Nausea - Mild to extreme nausea is commonly reported when consumed in moderate to high dosages and either passes once the tripper has vomited or gradually fades by itself as the peak sets in.
  • Loss of temperature regulation

Cognitive effects:

The head space of 2C-T-7 is described by many as one which is both insightful and relatively normal in its thought processes even at moderate to high dosages.

The total sum of these cognitive components regardless of the setting generally includes:

  • Enhancement of current mind state
  • Acceleration of thought
  • Feelings of fascination, importance and awe
  • Time distortion
  • Introspection
  • Outrospection
  • Removal of cultural filter
  • Conceptual thinking
  • Ego suppression, loss and death
  • Thought loops
  • Feelings of interdependent opposites
  • Delusions
  • States of unity and interconnectedness

Visual effects:

Enhancements

2C-T-7 presents a full and complete array of possible visual enhancements which generally includes:

  • Increased visual acuity
  • Enhancement of colour
  • Enhanced pattern recognition

Distortions

2C-T-7 presents a full and complete array of possible visual distortions which generally includes:

  • Drifting (Melting, Flowing, Breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in their appearance and extremely realistic in style but with a subtle digital/cartoonish form.
  • Tracers
  • After images
  • Texture repetition
  • Colour shifting
  • Scenery slicing

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT or Ayahuasca than that of LSD, 2C-B or 2C-I. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, sharp in their edges and equally rounded and angular in their corners. They give off a contradictory natural and synthetic feel with slightly more mystical and shamanic undertones to them in comparison to other phenethylamines. At higher dosages they are equally likely to result in states of Level 7A visual geometry and Level 7B. There seems to be visual geometry that is extremely similar to 2C-E and 2C-P and can be described as equal in intensity or complexity and equal in proportion to the accompanying cognitive and physical effects.

Hallucinatory states

2C-T-7 produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the phenethylamine family. These effects include:

  • External hallucinations
  • Internal hallucinations - In comparison to other psychedelics such as LSD, 2C-T-7 is very high in hallucinations embedded within visual geometry. This particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.

Auditory effects

The auditory effects of 2C-T-7 are more common in their occurrence than many more commonly used psychedelics and exhibit a full range of effects which commonly includes:

  • Enhancements
  • Distortions
  • Hallucinations

Health effects, addiction potential and tolerance:

The toxicity and long term health effects of recreational 2C-T-7 use does not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 2C-T-7 is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried 2C-T-7 within the psychedelic community suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed).

2C-T-7 does not seem to be physically addictive and many users experience a self regulating quality. There seems to be a tolerance build up when used consecutively multiple days in a row which requires one to double their dosage each time to achieve the same effects.

There is no current data for the LD50 of 2C-T-7, but it is thought to be high. Erowid does however have some annecdotal information on fatal dosages occurring at 35mg+ of insufflated dosages.

If 2C-T-7 does have MAOI effects, this could indicate that 2C-T-7 is more likely to induce serotonin syndrome, especially at high dosages, than other serotonergic hallucinogens. This may make it dangerous to combine with certain substances such as MDMA, AMT, Ayahuasca or any substance which releases neurotransmitters such as serotonin or those with similar pharmocological effects.

Legal issues:

  • 2C-T-7 is scheduled in Germany.
  • In Australia, 2C-T-2 and 2C-T-7 are covered by the country’s analogue drug laws.
  • 2C-T-7 is unscheduled in Canada.
  • The Netherlands was the first country in the world to ban 2C-T-7, after being sold in smartshops for a short period. After 2C-T-2 was first banned, 2C-T-7 quickly appeared on the market, but was soon banned as well. 2C-T-7 is a list I drug of the Opium Law.
  • Schedule I in Sweden. 2C-T-7 was first classified as “health hazard” under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of April 1, 1999 under SFS 1999:58 that made it illegal to sell or possess.
  • In 1999, Alexander Shulgin was sent a copy of a letter from the British Home Office to several of its administrative associates that in effect placed all compounds listed in PiHKAL into Class A.
  • On September 20, 2002, 2C-T-7 was classified as a Schedule I substance in the United States by an emergency ruling by the DEA. On March 18, 2004, the DEA published a Final Rule in the Federal Register permanently placing 2C-T-7 in Schedule I.

Conclusion:

2C-T-7 shows incredible depth on both an insightful and a recreational level with a full spectrum of deep psychedelic effects. It is completely worthy of its position within the magical half dozen and an extremely versatile compound. I would recommend this experience to anybody willing to try it in a safe and sensible manner.

This substance breakdown was written in collaboration with PsychonautWiki admin PJosepherum. For a more detailed breakdown please click the here.

DOB, broken down and described

image

Dosage:

Threshold : 0.2 mg
Light : 0.2 - 0.75 mg
Common : 0.75 - 1.75 mg
Strong : 1.75 - 2.5 mg
Heavy : 2.5 - 3.5 mg+

Duration:

Total duration : 7 - 17 hours
Onset / Initial effects : 30 - 90 mins
Coming up : 60 - 90 mins
Peak : 3 - 8 hrs
Coming down : 3 - 8 hrs
After effects : 4 - 8 hrs

Dimethoxybromoamphetamine (DOB), also known as Brolamfetamine and Bromo-DMA, is a psychedelic substituted alpha-methylated phenethylamine, a class of compounds commonly known as amphetamines. The phenethylamine equivalent of this substance (lacking the alpha-methyl group) is 2C-B.

This substance has no history of human usage prior to the 1991 publication of its synthesis and pharmacology in the book PiHKAL (Phenethylamines i Have Known And Loved) by Alexander Shulgin. In modern times it is used as a recreational drug and an entheogen, rarely sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors. It was first synthesized by Alexander Shulgin and described in his 1991 book.

In terms of its pharmacology, this substance acts as a selective 5-HT2A, 5-HT2B, and 5-HT2C receptor partial agonist. Its psychedelic effects are thought to be mediated via its actions on the 5-HT2A receptor.

The DOB experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical effects:

The physical effects of DOB can be broken down into six components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Spontaneous tactile sensations - The body high of DOB is manifested as somewhat intense in comparison to most classical psychedelics. The sensation itself can be described as a constantly present yet somewhat mild energetic pins and needles sensation that encompasses a person’s entire body. It is usually static in its position and felt over every square inch of the skin as if it was coming from behind the users body. Occasionally however it manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
  • Stimulation - In terms of its effects on the physical energy levels of the tripper, DOB is usually considered to be extremely stimulating at levels which do not become overwhelming and are encouraged instead of forced. This results in a shakiness and unsteadiness of the hands at high dosages but encourages trippers to move around, run, dance, climb and generally engage in physical activities. The level of stimulation varies between users however with some people reporting it to be somewhat similar to amphetamine in its intensity and others reporting that it is extremely subtle even at higher dosages. In comparison, other more commonly used psychedelics such as psilocin are generally sedating and relaxed.
  • Enhancement of touch - Feelings of enhanced tactile sensation are consistently present at moderate levels throughout most DOB trips.
  • Nausea - Mild to extreme nausea is reported when consumed in moderate to high dosages and either passes once the tripper has vomited or gradually fades by itself as the peak sets in.
  • Vasoconstriction - This effect is usually only present at higher dosages but can be particularly uncomfortable.

Cognitive effects:

The head space of DOB is described by many as one of mental stimulation and a powerful enhancement of a person’s current mental state. Many user report that it may not be as deep as other traditional psychedelics such as LSD or Psilocin and that it is comparatively empty in terms of its insightfulness.

The total sum of these cognitive components regardless of the setting generally includes:

  • Introspection - This component is consistently manifested only in the context of a non-social setting in which the user is alone.
  • Increased empathy, love and sociability - This component is inconsistently manifested only in the context of social settings in which one is within the company of others. These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA and 2C-B but still prove strong enough to provide long lasting therapeutic effects.
  • Acceleration of thought
  • Time distortion
  • Feelings of fascination, importance and awe
  • Conceptual thinking
  • Enhancement of current mind state
  • Ego suppression, loss and death

Visual effects:

Enhancements

DOB presents a full and complete array of possible visual enhancements which generally includes:

  • Increased visual acuity
  • Enhancement of colour
  • Enhanced pattern recognition

Distortions

DOB presents a full and complete array of possible visual distortions which generally includes:

  • Drifting (Melting, Flowing, Breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in their appearance and unrealistic/cartoon-like in style.
  • Tracers
  • After images
  • Texture repetition
  • Colour shifting
  • Scenery slicing

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of LSD, 25I-NBOME or 2C-B than that of Ayahuasca, Psilocin or 2C-E. They can be comprehensively described as unstructured in their organization, algorithmic in geometric style, intricate in complexity, small in size, fast and smooth in motion, colourful in scheme, glossy in colour, sharp in their edges and equally rounded and angular in their corners. They give off a synthetic feel to them that at higher dosages are significantly more likely to result in states of Level 7A visual geometry over Level 7B.

Hallucinatory states

DOB is capable of producing a full range of low and high level hallucinatory states in a fashion that is significantly less consistent and reproducible than that of many other commonly used psychedelics. These effects include:

  • External hallucinations
  • Internal hallucinations - Although DOB is technically capable of producing of hallucinatory states in a fashion that is on par with psilocin or DMT in its vividness and intensity, in comparison, these effects are extremely rare and inconsistent. Whilst traditional psychedelics such as LSA, Ayahuasca and Mescaline will induce internal hallucinations near consistently at level 5 geometry and above, DOB will for most simply go straight into Level 7A visual geometry. This lack of consistently induced hallucinatory breakthroughs means that for most, LSD is simply not as deep of an experience as certain other psychedelics.

Auditory effects:

The auditory effects of DOB are common in their occurrence and exhibit a full range of effects which commonly includes:

  • Enhancements
  • Distortions
  • Hallucinations

Health effects, addiction potential and tolerance:

The toxicity and long term health effects of recreational DOB use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because DOB is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried DOC within the psychedelic community suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly but nothing can be completely guaranteed.

DOB is not physically addictive and many users experience a frequency self-regulating quality to the drug. Tolerance for DOC seems to be very mild and does not build up without repeated use over a short period of time.

Legal Issues:

  • International: DOB is a Schedule I drug under the Convention on Psychotropic Substances.
  • Australia: DOB is schedule II
  • Canada: Listed as a Schedule 1 as it is an analogue of amphetamine.
  • New Zealand: DOB is Schedule I (Class A) in New Zealand. DOB would also qualify as an “Analogue” under New Zealand’s catch-all Analogues section in Schedule 3 / Class C of their drug laws that would make 2C-I, 2C-E, DOI, DOB, ephedrine, and pseudoephedrine Schedule 3 compounds in New Zealand.
  • Poland: DOB is controlled in Poland.
  • UK: DOB is Schedule I/Class A in the U.K., making it illegal to sell, buy, or possess without a license.

Conclusion:

Although DOB could be considered as bland and generic in comparison to DOC and other more traditional psychedelics, it is still a worthwhile experience and perfect for recreational events. This substance can be generally described as a less insightful version of LSD with a longer duration, generic visual and an emptier headspace.

Click here for a more comprehensive breakdown.

25B-NBOMe, broken down and described

image

Dosage:

Threshold : 100 µg
Light : 100 - 300 µg
Common : 350 - 700 µg
Strong : 700 - 1500 µg

Duration:

Total duration : 8 - 10 hrs
Onset / Initial effects : 15 - 60 mins
Coming up : 60 - 120 mins
Peak : 3 - 4 hrs
Coming down : 1 - 2 hrs
After effects : 5 - 24 hrs

25B-NBOMe or 2C-B-NBOMe is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-B.

It has nearly no history of human use prior to 2010 when it first became popular due its ease of purchase from online research chemical vendors.

25B-NBOMe has efficacy at the 5-HT2A receptor where it acts as a potent partial agonist. It was discovered in 2003 by Ralf Heim at the Free University of Berlin, it differs from 2C-B structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group as shown in the image above. This change in structure results in roughly a sixteen fold increase in potency when compared to 2C-B, allowing even the most extreme of dosages to fit in liquid form onto tabs and blotter paper (which people often mistake for LSD).

There are, however, methods of differentiating between LSD and adulterants like 25B-NBOMe with and without test kits.

For example, one of the key differences between 25B-NBOMe and LSD is that this substance is only active when taken through a sublingual or insufflated route. This means that in order to get the full effects, 25B-NBOMe blotter paper must be lightly chewed on within the mouth for 10 - 20 minutes and never immediately swallowed.

Insufflation, however, is not recommended due to the amount of people who have suffered through dangerous and often fatal overdoses due to this route of administration.

The 25B-NBOMe experience contains a complex and wide array of effects which based on the predefined potential subjective effects index found here, I will now begin to breakdown and describe.

Physical effects:

The physical effects of 25B-NBOMe can be broken down into six components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Sublingual numbing - assuming the substance has been taken sublingually, the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very obvious feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed. This is the key difference when it comes to determining whether your blotter paper contains LSD or one of the NBOMe series.
  • Spontaneous tactile sensations - the body high itself can be described as a generally mild, all-encompassing, soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of euphoria that become longer and more drawn out proportional to the dosage consumed.
  • Decreased bodily weight - in terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness.
  • Stimulation - in terms of its effects on the physical energy levels of the tripper, 25B-NBOMe is usually considered to be energetic and stimulating, but it can be considered less stimulating when compared to 25I-NBOMe. For most people, this substance induces a unique type of physical stimulation which can be described as feeling extremely energetic but in a way which does not force the tripper to move unless they genuinely choose to do so. For others however, the stimulation can be quite uncontrollable, occasionally resulting in bodily shakes and a grinding of the teeth comparable to that of MDMA and traditional stimulants such as amphetamine, but this is manifested much less consistently when compared to 25I-NBOMe
  • Vasoconstriction - it is worth noting that an undetermined percentage of people who experiment with this drug will experience negative physical side effects, such as a temporary difficulty in urinating and vasoconstriction. This is defined as the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels and is triggered through the way in which 25B-NBOMe’s target receptor (5-HT2A) modulates both vasoconstriction and vasodilation among its many other functions.
  • Nausea - as the tripper begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, but passes once this has either happened or the trip begins to fully set in. In comparison to other psychedelics such as psilocin, LSD, 2C-E and 2C-I, this could actually be very considered very mild in its intensity.

Cognitive effects:

The head space of 25B-NBOMe is described by many as remarkably light and underwhelming in comparison to the classical psychedelics. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout low to moderate dosages. At high dosages however, mild to overwhelming cognitive alterations become present.

The most prominent of these cognitive effects generally include:

  • Introspection - this component is consistently manifested only in the context of a non-social setting in which the user is alone.
  • Increased empathy, love and sociability - the entactogenic effects range from mild to powerful, but are inconsistently manifested. entactogenic effects for people who try this substance usually become prominent in the presence of others. These feelings of increased sociability, love and empathy do not seem to be quite as strong or profound as those found within other entactogens (such as MDMA, 2C-B and AMT)
  • Acceleration of thought
  • Time distortion
  • Feelings of fascination, importance and awe
  • Conceptual thinking
  • Connectivity of thought
  • Enhancement of current mind state
  • Removal of cultural filter
  • Ego suppression, loss and death

Visual effects:

Enhancements

25B-NBOMe presents a full and complete array of possible visual enhancements which generally includes:

  • Increased visual acuity
  • Enhancement of colour
  • Enhanced pattern recognition

Distortions

The visual distortions and alterations which are experienced are detailed below:

  • Drifting (Melting, Flowing, Breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in their appearance and unrealistic/cartoon-like in style.
  • Tracers
  • After images
  • Texture repetition
  • Colour shifting
  • Scenery slicing

Geometry

The visual geometry that is present throughout this trip is often described as similar in appearance to that of LSD. They can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colourful in scheme, glossy in colour, sharp around the edges and mostly rounded across their corners. In comparison to other more commonly used psychedelics they can be described as significantly more intricate than the visual geometry found within 2C-I and most of the 2C-x family in general as well as completely on par with LSD, Psilocin and DMT at appropriately high dosages.

In terms of their behaviour, 25B-NBOMe’s geometry leads onto Level 7A visual geometry with Level 7B remaining so far unconfirmed within this substance. They also seem to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelops the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it.

Hallucinatory states

25B-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. However, level 4 hallucinatory breakthroughs are reported but very uncommon and inconsistent in comparison to other more commonly used psychedelics such as psilocin, 2C-E and DMT.

These effects include:

  • External hallucinations
  • Internal hallucinations - this particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of religious, spiritual, mystical or a transcendental nature in their overall theme.

Auditory effects:

The auditory effects of 25B-NBOMe are common in their occurrence and exhibit a full range of effects which commonly includes:

  • Enhancements
  • Distortions
  • Hallucinations

Health effects, addiction potential and tolerance:

25B-NBOMe is a very new substance and little is known about its pharmacological or behavioural risks. The LD50 is not known. Some deaths have been attributed to 25B-NBOMe overdose caused by improper handling and uneducated use of this substance. Its recent widespread use suggests that death is primarily caused from overdoses and not from ordinary doses, particularly from insufflation.

The fact that 25B-NBOMe is active in the microgram range is likely a contributing factor since this makes measuring doses significantly more difficult. 

In terms of its addictive potential, 25B-NBOMe has not been studied formally but due to its immediate tolerance build up which lasts up to 2 - 3 weeks after the experience, it is essentially impossible to use this substance compulsively.

Legal issues:

  • UK: 25B-NBOMe is under a temporary class drug order, lasting one year from 10th June 2013.
  • Sweden: 25b-NBOMe is classed as schedule I.
  • USA: On Nov 15, 2013, the DEA added 25B-NBOMe to Schedule I using their emergency scheduling powers, making it “temporarily” in Schedule I for 2 years.

Conclusion:

As for the substance itself, 25B-NBOMe  and the NBOMe series as a whole are an extremely interesting set of psychedelics but do not quite compare in terms of hallucinatory and cognitive depth if you have access to classical psychedelics such as genuine LSD, DMT and psilocin.

Please let me know if you agree or disagree with any particular points contained within this article by using the comment system below.

Click here for a more comprehensive article.

updates updates updates

It may seem that I have been inactive recently due to a general lack of new original posts but I and others have been working extremely hard on overhauling and expanding upon the content within both DEIS and PsychonautWiki. This post is essentially a list of specific updates to inform my readers on the progress, changes and future of this website which can be found below:

  • Psychedelics (Visual/Cognitive/Miscellaneous), Deliriants and Dissociative breakdowns have each received grammatical and descriptive overhauls.
  • New previously undocumented psychedelic cognitive components added: Outrospection, Mindfulness, Multiple thought streams, Personality regression, Thought loops, Feelings of interdependent opposites and Delusions.
  • New previously undocumented dissociative components: Environmental Cubism, Environmental Orbism.
  • Hallucinatory states split into External and Internal hallucination categories for all hallucinogen breakdowns.
  • Documentation article removed and stylistic variations of individual components (Geometry, Drifting, Spontaneous tactile sensations, etc) have simply been integrated into pre-existing articles for hallucinogen category breakdowns.
  • All specific substance breakdowns have been updated to follow a consistent and standardized layout. This no longer describes each effect unless it contains a specific style or variation and instead asks one to refer back to our centralized potential subjective effects index for a detailed explanation.
  • Responsible use page overhauled to be more comprehensive and legitimate.
  • Non hallucinogenic substance categories added to PsychonautWiki with many more to come: Entactogens, Stimulants, Depressants, Nootropics, Opioids, Benzodiazapines.
  • Non hallucinogenic breakdowns added to PsychonautWiki with many more to come: Amphetamine, Methylphenidate, Heroin, Codeine, TramadolModafanilAlprazolam and Cannabis.
  • We now have an extremely active and dedicated community which is constantly progressing www.PsychonautWiki.org as we approach the release of V1.0. We are always looking for contributors and encourage you to visit our active IRC chatroom to talk with myself and other admins.
  • Adverts have been implemented on DEIS. Sorry about this. You are welcome to hide them with AdBlock and an explanation of why this has been done can be found here.

As for the future, we are currently in the process of working on a full release for PsychonautWiki and have ten or so individual psychedelic substance breakdowns to post over up the upcoming weeks.

Thanks for reading and have a nice day <3

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